Clinical review: Treatment of heat stroke: Should dantrolene be considered?

Critical Care

Volumn 9, Issue 1, 2005, Pages 86-91

  Hadad, Eran ^a   Cohen Sivan, Yoav ^a   Heled, Yuval ^a   Epstein, Yoram ^a,b  

^a HELLER INSTITUTE OF MEDICAL RESEARCH   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Cooling; Dantrolene; Exertional heat stroke; Heat stroke; Hyperthermia; Temperature

Indexed keywords

DANTROLENE; HYDANTOIN DERIVATIVE; MANNITOL; PLACEBO; SODIUM HYDROXIDE;

CLINICAL TRIAL; COMA; CONVULSION; COOLING; DELIRIUM; DIARRHEA; DISEASE MODEL; DISEASE SEVERITY; DOSE RESPONSE; DROWSINESS; DRUG EFFICACY; DRUG EXCRETION; DRUG FORMULATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG USE; EMERGENCY TREATMENT; FATIGUE; HEAT STROKE; HUMAN; INDUCED HYPOTHERMIA; LIVER INJURY; LIVER TOXICITY; MALAISE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

DANTROLENE; FEMALE; FEVER; HALF-LIFE; HEAT STROKE; HEPATITIS, TOXIC; HUMANS; HYPOTHERMIA, INDUCED; MALE; MUSCLE RELAXANTS, CENTRAL;

EID: 13844281633     PISSN: 13648535     EISSN: None     Source Type: Journal    
DOI: 10.1186/cc2923     Document Type: Review

References (54)

1. Epstein Y, Sohar E, Shapiro Y: Exertional heat stroke: a preventable condition. Isr J Med Sci 1995, 31:454-462.
2. Chan TC, Evans SD, Clark RF: Drug-induced hyperthermia. Crit Care Clin 1997, 13:785-808.
3. Wyndham CH, Strydom NB, Cooke HM: Methods of cooling subjects with hyperpyrexia. J Appl Physiol 1959, 14: 71-776.
4. Weiner JS, Khogali M: A physiological body-cooling unit for treatment of heat stroke. Lancet 1980, 1:507-509.
5. Al-Aska AK, Abu-Aisha H, Yaqub B, Al-Harthy SS, Sallam A: Simplified cooling bed for heatstroke [letter]. Lancet 1987, 1:381.
6. Armstrong LE, Crago AE, Adams R, Roberts WO, Maresh CM: Whole-body cooling of hyperthermic runners: comparison of two field therapies. Am J Emerg Med 1996, 14:355-358.
7. Costrini A: Emergency treatment of exertional heatstroke and comparison of whole body cooling techniques. Med Sci Sports Exerc 1990, 22:15-18.
8. Denborough MA: Heat stroke and malignant hyperpyrexia. Med J Aust 1982, 1:204-205.
9. Meyers EF, Meyers RW: Thermic stress syndrome. JAMA 1982, 247:2098-2099.
10. Meyers EF: Thermic stress syndrome. Prev Med 1979, 8:520-522.
11. Kozack JK, MacIntyre DL: Malignant hyperthermia. Phys Ther 2001, 81:945-951.
12. Wedel DJ, Quinlan JG, Iaizzo PA: Clinical effects of intravenously administered dantrolene. Mayo Clin Proc 1995, 70: 241-246.
13. Strazis KP, Fox AW: Malignant hyperthermia: a review of published cases. Anesth Analg 1993, 77:297-304.
14. Persing JS: Neuroleptic malignant syndrome: an overview. S D J Med 1994, 47:51-55.
15. Lydiatt JS, Hill GE: Treatment of heat stroke with dantrolene. JAMA 1981, 246:41-42.
16. Amsterdam JT, Syverud SA, Barker WJ, Bills GR, Goltra DD, Armao JC, Hedges JR: Dantrolene sodium for treatment of heatstroke victims: lack of efficacy in a canine model. Am J Emerg Med 1986, 4:399-405.
17. Channa AB, Seraj MA, Saddique AA, Kadiwal GH, Shaikh MH, Samarkandi AH: Is dantrolene effective in heat stroke patients? Crit Care Med 1990, 18:290-292.
18. Moran D, Epstein Y, Wiener M, Horowitz M: Dantrolene and recovery from heat stroke. Aviat Space Environ Med 1999, 70: 987-989.
19. Zuckerman GB, Singer LP, Rubin DH, Conway EE Jr: Effects of dantrolene on cooling times and cardiovascular parameters in an immature porcine model of heatstroke. Crit Care Med 1997, 25: 35-139.
20. Tayeb OS, Marzouki ZM: Effect of dantrolene pretreatment on heat stroke in sheep. Pharmacol Res 1990, 22:565-572.
21. Bouchama A, Cafege A, Devol EB, Labdi O, El-Assil K, Seraj M: Ineffectiveness of dantrolene sodium in the treatment of heatstroke. Crit Care Med 1991, 19:176-180.
22. Watson JD, Ferguson C, Hinds CJ, Skinner HR, Coakley JH: Exertional heat stroke induced by amphetamine analogues. Does dantrolene have a place? Anaesthesia 1993, 48:1057-1060.
23. Morgan KG, Bryant SH: The mechanism of action of dantrolene sodium. J Pharmacol Exp Ther 1977, 201:138-147.
24. 2+ concentration upon dantrolene action on exitation contraction coupling in frog skeletal muscle. Can J Physiol Pharmacol 1981, 59: 58-363.
25. Ward A, Chaffman MO, Sorkin EM: Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity. Drugs 1986, 32:130-168.
26. Dykes MH: Evaluation of a muscle relaxant: dantrolene sodium (Dantrium). JAMA 1975, 231:862-864.
27. Lietman PS, Haslam RH, Walcher JR: Pharmacology of dantrolene sodium in children. Arch Phys Med Rehabil 1974, 55:388-392.
28. Meyler WJ, Mols-Thurkow HW, Wesseling H: Relationship between plasma concentration and effect of dantrolene sodium in man. Eur J Clin Pharmacol 1979, 16:203-209.
29. Krause T, Gerbershagen MU, Fiege M, Weishorn R, Wappler F: Dantrolene - A review of its pharmacology, therapeutic use and new developments. Anesthesia 2004, 59:364-373.
30. Dykes MH: Evaluation of a muscle relaxant: dantrolene sodium (Dantrium). JAMA 1975, 231:862-864.
31. Utili R, Boitnott JK, Zimmerman HJ: Dantrolene-associated hepatic injury. Incidence and character. Gastroenterology 1977, 72:610-616.
32. Bouchama A, Knochel JP: Heat stroke. N Engl J Med 2002, 346: 1978-1988.
33. Epstein Y: Exertional heatstroke: lessons we tend to forget. Am J Med Sports 2000, 2:143-152.
34. Shibolet S, Coll R, Gilat T, Sohar E: Heatstroke: its clinical picture and mechanism in 36 cases. Q J Med 1967, 36: 25-547.
35. Semenza JC, Rubin CH, Falter KH, Selanikio JD, Flanders WD, Howe HL, Wilhelm JL: Heat-related deaths during the July 1995 heat wave in Chicago. N Engl J Med 1996, 335:84-90.
36. Epstein Y, Moran DS, Shapiro Y, Sohar E, Shemer J: Exertional heat stroke: a case series. Med Sci Sports Exerc 1999, 31:224-228.
37. Jardon OM: Physiologic stress, heat stroke, malignant hyperthermia: a perspective. Mil Med 1982, 147:8-14.
38. Bratell S, Folmerz P, Hansson R, Jonsson O, Lundstam S, Pettersson S, Rippe B, Schersten T: Effects of oxygen free radical scavengers, xanthine oxidase inhibition and calcium entry-blockers on leakage of albumin after ischaemia. An experimental study in rabbit kidneys. Acta Physiol Scand 1988, 134: 35-41.
39. Del Maestro R, Thaw HH, Bjork J, Planker M, Arfors KE: Free radicals as mediators of tissue injury. Acta Physiol Scand Suppl 1980, 492:43-57.
40. Knochel JP: Treatment of heat stroke. JAMA 1983, 249:1006-1007.
41. Leong P, MacLennan DH: The cytoplasmic loops between domains II and III and domains III and IV in the skeletal muscle dihydropyridine receptor bind to a contiguous site in the skeletal muscle ryanodine receptor. J Biol Chem 1998, 273:29958-29964.
42. Denborough M: Malignant hyperthermia. Lancet 1998, 352: 1131-1136.
43. Tobin JR, Jason DR, Challa VR, Nelson TE, Sambuughin N: Malignant hyperthermia and apparent heat stroke. JAMA 2001, 286: 168-169.
44. Bourdon L, Canini F: On the nature of the link between malignant hyperthermia and exertional heatstroke. Med Hypotheses 1995, 45:268-270.
45. Bendahan D, Kozak-Ribbens G, Rodet L, Confort-Gouny S, Cozzone PJ: 31Phosphorus magnetic resonance spectroscopy characterization of muscular metabolic anomalies in patients with malignant hyperthermia: application to diagnosis. Anesthesiology 1998, 88:96-107.
46. Shapiro Y, Seidman DS: Field and clinical observations of exertional heat stroke patients. Med Sci Sports Exerc 1990, 22:6-14.
47. Orser B: Dantrolene sodium and heatstroke. Crit Care Med 1992, 20:1192-1193.
48. Britt BA: Dantrolene. Can Anaesth Soc J 1984, 31:61-75.
49. Odeh M: The role of reperfusion-induced injury in the pathogenesis of the crush syndrome. N Engl J Med 1991, 324: 417-1422.
50. Parr MJ, Willatts SM: Fatal theophylline poisoning with rhabdomyolysis. A potential role for dantrolene treatment. Anaesthesia 1991, 46:557-559.
51. 2+ concentration during exertional rhabdomyolysis. Lancet 1995, 345:424-425.
52. Amelink GJ, Van der Kallen CJ, Wokke JH, van Asberk BS, Bar PR: Dantrolene sodium diminishes exercise-induced muscle damage in the rat. Eur J Pharmacol 1990, 179:187-192.
53. Bigard AX, Merino D, Lienhard F, Serrurier B, Guezennec CY: Muscle damage induced by running training during recovery from hindlimb suspension: the effect of dantrolene sodium. Eur J Appl Physiol Occup Physiol 1997, 76:421-427.
54. Pagala M, Amaladevi B, Bernstein A, Herzlich B, Namba T, Grob T: Dantrolene sodium reduces the enhanced leakage of creatine kinase caused by ethanol, cocaine, and electrical stimulation in isolated fast and slow muscles of rat. Alcohol Clin Exp Res 1997, 21: 3-67.