Radial 'glial' progenitors: Neurogenesis and signaling

Current Opinion in Neurobiology

Volumn 15, Issue 1, 2005, Pages 29-33

  Ever, Leah ^a   Gaiano, Nicholas ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; FIBROBLAST GROWTH FACTOR; NOTCH RECEPTOR;

BRAIN DEVELOPMENT; CELL MIGRATION; CELL STRUCTURE; GENE CONTROL; GENE MAPPING; GLIA CELL; HUMAN; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 13844264534     PISSN: 09594388     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.conb.2005.01.005     Document Type: Review

References (25)

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14. ••].
15. ••] used hGFAP-Cre to mark RG. These studies provide important in vivo evidence that RG are neurogenic, although they reach different conclusions about the neurogenic potential of RG in the ventral telencephalon. This discrepancy is probably a function of differences in the timing of Cre-mediated recombination.
16. N. Gaiano, J.S. Nye, and G. Fishell Radial glial identity is promoted by Notch1 signaling in the murine forebrain Neuron 26 2000 395 404
17. N. Gaiano, and G. Fishell The role of notch in promoting glial and neural stem cell fates Annu Rev Neurosci 25 2002 471 490
18. K. Yoon, S. Nery, M.L. Rutlin, F. Radtke, G. Fishell, and N. Gaiano Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors J Neurosci 24 2004 9497 9506 This study extends the previous observation that Notch1 promotes radial glial character in vivo. Using a similar experimental paradigm, the authors demonstrate that cells expressing activated Notch1 in vivo show increased neurosphere frequency in media containing FGF2. This work goes on to show that activation of FGFR2 in vivo also promotes radial glial characteristics, and provides correlative evidence that the effects of Notch1 in telencephalic progenitors might be mediated by FGFR2.
19. B.A. Patten, J.M. Peyrin, G. Weinmaster, and G. Corfas Sequential signaling through Notch1 and erbB receptors mediates radial glia differentiation J Neurosci 23 2003 6132 6140 The authors examine the role of Notch and ErbB signaling in Bergman radial glia of the cerebellum. They show that neuronal contact activates the Notch signaling cascade and that ErbB2 is a CBF1-independent Notch target. They also show that blocking ErbB signaling antagonizes radial glial characteristics and argue that ErbB2 signaling mediates the ability of Notch to promote radial glial identity.
20. L.S. Campos, A.J. Duarte, T. Branco, and D. Henrique mDll1 and mDll3 expression in the developing mouse brain: role in the establishment of the early cortex J Neurosci Res 64 2001 590 598
21. D.J. Solecki, X.L. Liu, T. Tomoda, Y. Fang, and M.E. Hatten Activated Notch2 signaling inhibits differentiation of cerebellar granule neuron precursors by maintaining proliferation Neuron 31 2001 557 568
22. R.S. Schmid, B. McGrath, B.E. Berechid, B. Boyles, M. Marchionni, N. Sestan, and E.S. Anton Neuregulin 1-erbB2 signaling is required for the establishment of radial glia and their transformation into astrocytes in cerebral cortex Proc Natl Acad Sci USA 100 2003 4251 4256 The authors extend their previous findings implicating NRG-ErbB signaling in the promotion of radial glial characteristics. Here, they show that reducing ErbB signaling, by either mutating NRG or expressing dominant negative ErbB2, leads to a reduction in the number of cells with radial glial characteristics, and a promotion of astrocyte fate. This study also suggests that ErbB2 is a transcriptional target of the Notch-CBF1 signaling cascade.
23. E.S. Anton, M.A. Marchionni, K.F. Lee, and P. Rakic Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex Development 124 1997 3501 3510
24. Y. Ohkubo, A.O. Uchida, D. Shin, J. Partanen, and F.M. Vaccarino Fibroblast growth factor receptor 1 is required for the proliferation of hippocampal progenitor cells and for hippocampal growth in mouse J Neurosci 24 2004 6057 6069 The authors use the hGFAP-Cre line in an effort to delete FGFR1 specifically in radial glial progenitors in vivo. This study focuses on the hippocampus, and makes the interesting observation that deletion of FGFR1 in RG almost completely abolishes neurosphere formation. This result provides compelling evidence that most hippocampal neurospheres are derived from RG, as least as defined by the hGFAP promoter.
25. C. Gregg, and S. Weiss Generation of functional radial glial cells by embryonic and adult forebrain neural stem cells J Neurosci 23 2003 11587 11601 The authors combined in vitro and in vivo studies to examine the role of epidermal growth factor and FGF signaling in neural progenitors. They find that for embryonic progenitors EGF, but not FGF, can promote the development of radial glial characteristics. They suggest that this difference might be the result of different levels of mitogen-activated protein kinase (MAPK) signaling downstream of the different receptors. Interestingly, they also find that ependymal cells in the adult forebrain can 'de-differentiate' to adopt radial glial characteristics in response to EGF signaling.