Development of interactive software for Bayesian optimal phase 1 clinical trial design

Drug Information Journal

Volumn 39, Issue 1, 2005, Pages 89-98

  Rosenberger, William F ^a,b   Canfield, Gerald C ^a   Perevozskaya, Inna ^c   Haines, Linda M ^d   Hausner, Petr ^b,e  

^a UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d UNIVERSITY OF KWAZULU NATAL   (South Africa)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Bayesian optimal design; Maximum tolerated dose; Prior elicitation; Quantile estimation; User interface

Indexed keywords

UNCLASSIFIED DRUG;

ARTICLE; BAYES THEOREM; BIOSTATISTICS; CLINICAL RESEARCH; CLINICAL TRIAL; COMPUTER PROGRAM; DOSE CALCULATION; DRUG DESIGN; DRUG OVERDOSE; HUMAN; INTERNET; MATHEMATICAL ANALYSIS; METHODOLOGY; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PROCESS OPTIMIZATION; TEAMWORK;

EID: 13844264266     PISSN: 00928615     EISSN: None     Source Type: Journal    
DOI: 10.1177/009286150503900112     Document Type: Article

References (14)

1. Perevozskaya I. Constrained Bayesian Optimal Designs for Phase I Clinical Trials. Baltimore: University of Maryland; 2001 (doctoral dissertation).
2. Haines LM, Perevozskaya I, Rosenberger WF. Bayesian optimal designs for phase I clinical trials. Biometrics. 2003;59:591-600.
3. Rosenberger WF, Haines LM. Competing designs for phase I clinical trials: a review. Stat Med. 2002;21:2757-2770.
4. Atkinson AC, Donev AN. Optimum Experimental Designs. Oxford, United Kingdom: Clarendon; 1992.
5. Clyde M, Chaloner K. The equivalence of constrained and weighted designs in multiple objective problems. J Am Stat Assoc. 1996;91:1236-1244.
6. Babb J, Rogatko A, Zacks S. Cancer phase I clinical trials: efficient dose escalation with overdose control. Stat Med. 1994;17:1103-1120.
7. Whitehead J, Brunier H. Bayesian decision procedures for dose determining experiments. Stat Med. 1995;14:885-893.
8. Whitehead J, Williamson D. Bayesian decision procedures based on logistic regression models for dose-finding studies. Stat Med. 1998;8:445-467.
9. Pukelsheim F. Optimal Design of Experiments. New York: Wiley: 1993.
10. Flournoy N. A clinical experiment in bone marrow transplantation: estimating a percentage point of a quantal response curve. In Case Studies in Bayesian Statistics. Gatsonis C, Hodges JS, Kass RE, Singpurwalla ND, eds. New York: Springer; 1993.
11. Tsutakawa RK. Bayesian inference for bioassay. Technical Report 52. Columbia, MO: University of Missouri; 1975.
12. Whitehead J, Zhou Y, Patterson S, Webber D, Francis S. Easy-to-implement Bayesian methods for dose-escalation studies in healthy volunteers. Biostatistics. 2001;2:47-61.
13. McLeish DL, Tosh D. Sequential designs in bioassay. Biometrics. 1990;46:103-116.
14. Silvapulle M. On the existence of maximum likelihood estimators for the binomial response models. J Roy Stat Soc. B 1981;43:310-313.