Pro/con clinical debate: It is acceptable to stop large multicentre randomized controlled trials at interim analysis for futility

Critical Care

Volumn 9, Issue 1, 2005, Pages 34-36

  Schoenfeld, David A ^a   Meade, Maureen O ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

Clinical research; Futility; Interim analysis; Randomized controlled trials; Stopping rules

Indexed keywords

DRUG;

CLINICAL RESEARCH; CLINICAL STUDY; CLINICAL TRIAL; DRUG WITHDRAWAL; HUMAN; INTENSIVE CARE; MEDICAL DECISION MAKING; MORTALITY; POSITIVE END EXPIRATORY PRESSURE; PRIORITY JOURNAL; PROFESSIONAL STANDARD; RESOURCE MANAGEMENT; RESPIRATORY DISTRESS SYNDROME; REVIEW; SAMPLE SIZE; STANDARDIZATION; TREATMENT OUTCOME; CONTROLLED CLINICAL TRIAL; HEALTH PERSONNEL ATTITUDE; MULTICENTER STUDY; NOTE; RANDOMIZED CONTROLLED TRIAL; ARTICLE; TREATMENT WITHDRAWAL;

ATTITUDE OF HEALTH PERSONNEL; HUMANS; MEDICAL FUTILITY; MULTICENTER STUDIES; RANDOMIZED CONTROLLED TRIALS; WITHHOLDING TREATMENT;

EID: 13844256828     PISSN: 13648535     EISSN: None     Source Type: Journal    
DOI: 10.1186/cc3013     Document Type: Review

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