Inflammatory cytokines activate p38 MAPK to induce osteoprotegerin synthesis by MG-63 cells

Biochemical and Biophysical Research Communications

Volumn 329, Issue 1, 2005, Pages 224-229

  Pantouli, Ekaterini ^a   Boehm, Matthew M ^a   Koka, Sreenivas ^b  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b MAYO CLINIC   (United States)

Author keywords

IL 1 ; Inflammatory cytokine; MAP kinase; Osteoblast; Osteoprotegerin; Signal transduction; TNF

Indexed keywords

INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; OSTEOPROTEGERIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CELL LINE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

EID: 13844255698     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.01.122     Document Type: Article

References (18)

1. S.R. Goldring, M.B. Goldring, and J. Buckwalter The role of cytokines in cartilage matrix degeneration in osteoarthritis Clin. Orthop. Rel. Res. 427 Suppl. 2004 S27 S36
2. P. Stashenko Tissue levels of bone resorptive cytokines in periodontal disease J. Periodontol. 62 8 1991 504 509
3. P. Stashenko Levels of interleukin 1 beta in tissue from sites of active periodontal disease J. Clin. Periodontol. 18 7 1991 548 554
4. S. Dayan Oral epithelial overexpression of IL-1alpha causes periodontal disease J. Dent. Res. 83 10 2004 786 790
5. L.C. Hofbauer, and M. Schoppet Clinical implications of the osteoprotegerin/RANKL/RANK system for bone and vascular diseases JAMA 292 4 2004 490 495
6. N. Udagawa Osteoprotegerin produced by osteoblasts is an important regulator in osteoclast development and function Endocrinology 141 9 2000 3478 3784
7. S. Khosla Minireview: The OPG/RANKL/RANK system Endocrinology 142 12 2001 5050 5055
8. J.E. Aubin, and E. Bonnelye Osteoprotegerin and its ligand: A new paradigm for regulation of osteoclastogenesis and bone resorption Osteopor. Int. 11 11 2000 905 913
9. L.C. Hofbauer The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption J. Bone Min. Res. 15 1 2000 2 12
10. S.L. Teitelbaum Bone resorption by osteoclasts Science 289 5484 2000 1504 1508
11. G. Pearson Mitogen-activated protein (MAP) kinase pathways: Regulation and physiological functions Endocr. Rev. 22 2 2001 153 183
12. C.R. Weston, and R.J. Davis The JNK signal transduction pathway Curr. Opin. Genet. Dev. 12 1 2002 14 21
13. C.R. Weston, D.G. Lambright, and R.J. Davis Signal transduction. MAP kinase signaling specificity Science 296 5577 2002 2345 2347
14. O.N. Vidal Osteoprotegerin mRNA is increased by interleukin-1 alpha in the human osteosarcoma cell line MG-63 and in human osteoblast-like cells Biochem. Biophys. Res. Commun. 248 3 1998 696 700
15. H. Brandstrom Tumor necrosis factor-alpha and -beta upregulate the levels of osteoprotegerin mRNA in human osteosarcoma MG-63 cells Biochem. Biophys. Res. Commun. 248 3 1998 454 457
16. S.J. Webb Regulation of TNF-alpha-induced IL-6 production in MG-63 human osteoblast-like cells J. Dent. Res. 81 1 2002 17 22
17. J. Zhang PDGF induces osteoprotegerin expression in vascular smooth muscle cells by multiple signal pathways FEBS Lett. 521 1-3 2002 180 184
18. M. Tazoe Involvement of p38MAP kinase in bone morphogenetic protein-4-induced osteoprotegerin in mouse bone-marrow-derived stromal cells Arch. Oral Biol. 48 8 2003 615 619