Prospective evaluation of folic acid supplementation on plasma homocysteine concentrations during weight reduction: A randomized, double-blinded, placebo-controlled study in obese women

Life Sciences

Volumn 76, Issue 18, 2005, Pages 2137-2145

  Sheu, Wayne Huey Herng ^a,b,d   Chin, Huei Min Linda ^c   Lee, Wen Jane ^a   Wan, Chu Jen ^a   Su, Hsiu Yueh ^c   Lang, Hui Fen ^a  

^a Dept of Med Education and Research ^*  (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^d TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

Folic acid; Homocysteine; Weight reduction

Indexed keywords

FOLIC ACID; HOMOCYSTEINE; PLACEBO;

ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; BODY MASS; CLINICAL ARTICLE; CLINICAL TRIAL; CONCENTRATION (PARAMETERS); CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DIET RESTRICTION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EXERCISE; FEMALE; FOLIC ACID BLOOD LEVEL; HUMAN; OBESITY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; STATISTICAL SIGNIFICANCE; WEIGHT REDUCTION;

EID: 13844254312     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2004.12.002     Document Type: Article

References (32)

1. C.C. Allain, L.S. Poon, C.S. Chan, W. Richmond, and P.C. Fu Enzymatic determination of total serum cholesterol Clin. Chem. 20 1974 470 475
2. J.L. Anderson, J.B. Muhlestein, B.D. Horne, J.F. Carlquist, T.L. Bair, T.E. Madsen, and R.R. Pearson Plasma homocysteine predicts mortality independently of traditional risk factors and C-reactive protein in patients with angiographically defined coronary artery disease Circulation 102 2000 1227 1232
3. P.S. Bachorik, and J.J. Albers Precipitation methods of quantification of lipoprotein J.J. Albers J.P. Segrest Methods in Enzymology vol. 129 1986 Academic Press London 78 100
4. F. Borson-Chazot, C. Harthe, F. Teboul, F. Labrousse, C. Guame, L. Guadagnino, B. Claustrat, F. Berthezene, and P. Moulin Occurrence of hyperhomocysteinemia 1 year after gastroplasty for severe obesity J. Clin. Endocrinol. Metab. 84 1999 541 545
5. C.J. Boushey, S.A. Beresford, G.S. Omenn, and A.G. Motulsky A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes JAMA 274 1995 1049 1057
6. S.T. Chou, L.E. Ko, P.S. Lim, J.L. Huang, and C.S. Yang Effect of age and sex on plasma total homocysteine in Taiwanese subjects Chin. J. Physiol. 31 2000 159 164
7. V. Fonesca, S.C. Guba, and L.M. Fink Hyperhomocysteinemia and the endocrine system: implications for atherosclerosis and thrombosis Endocr. Rev. 29 1999 738 759
8. W.T. Friedewald, R.I. Levy, and D.S. Fredrickson Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge Clin. Chem. 18 1972 449 502
9. S. Gallistle, K.M. Sudi, R. Aigner, and M. Borkenstein Determinants of homocysteine during weight reduction in obese children and adolescents Metabolism 50 2001 1220 1223
10. C.R. Hankey, M.E. Lean, G.D. Lowe, A. Rumley, and M. Woodward Effects of moderate weight loss on anginal symptoms and indices of coagulation and fibrinolysis in overweight patients with angina pectoris Eur. J. Clin. Nutr. 56 2002 1039 1045
11. C.G. Hanratty, L.T. McGrath, D.F. McAuley, I.S. Young, and G.D. Johnston The effect of oral methionine and homocysteine on endothelial function Heart 85 2001 326 330
12. B.F. Henning, M. Tepel, R. Riezler, A. Gillessen, and C. Doberauer Vitamin supplementation during weight reduction - favourable effect on homocysteine metabolism Res. Exp. Med. (Berl) 198 1998 37 42
13. Homocysteine Lowering Trialists' Collaboration Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomized trials BMJ 316 1998 894 898
14. H.B. Hubert, M. Feinleib, P.M. McNamara, and W.P. Castelli Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study Circulation 67 1983 968 977
15. P.F. Jacques, A.G. Bostom, R.R. Williams, R.C. Ellison, J.H. Eckfeldt, I.H. Rosenberg, J. Selhub, and R. Rozen Relation between folate status, a common mutation in methylenetetrahydrofolate reductase and plasma homocysteine concentrations Circulation 93 1996 7 9
16. A. Lobo, A. Naso, K. Arheart, W.D. Kruger, T. About-Ghazala, F. Alsous, M. Nahlawi, A. Gupta, A. Moustapha, F. val Lente, D.W. Jacobsen, and K. Robinson Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B6 and B12 Am. J. Cardiol. 83 1999 821 825
17. D.R. Matthews, J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher, and R.C. Turner Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations Diabetologia 28 1985 412 419
18. O. Mayer, J. Filipovsky, M. Hromadka, V. Svobodova, J. Racek, and O. Mayer Treatment of hyperhomocysteinemia with folic acid: effects on homocysteine levels, coagulation status, and oxidative stress markers J. Cardiovasc. Pharmacol. 39 2002 851 857
19. I. Mertens, and L.F. Van Gaal Obesity, haemostasis and the fibrinolytic system Obes. Rev. 3 2002 85 101
20. A. Oshaug, K.H. Bugge, and H. Refsum Diet, an independent determinant for plasma total homocysteine. A cross sectional study of Norwegian workers on platforms in the North Sea Eur. J. Clin. Nutr. 52 1998 7 11
21. F. Perticone, R. Ceravolo, M. Candigliota, G. Ventura, S. Iacopino, F. Sinopoli, and P.L. Mattioli Obesity and body fat distribution induce endothelial dysfunction by oxidative stress: protective effect of vitamin C Diabetes 50 2001 159 165
22. H.S. Randeva, K.C. Lewandowski, J. Drzeworski, K. Brooke-Wavell, C. O'Callaghan, L. Czupryniak, E.W. Hillhouse, and G.M. Prelevic Exercise decreases plasma total homocysteine in overweight young women with polycystic ovary syndrome J. Clin. Endocrinol. and Metab. 87 2002 4496 4501
23. A. Reitman, I. Friedrich, A. Ben-Amotz, and Y. Levy Low plasma antioxidants and normal plasma B vitamins and homocysteine in patients with severe obesity Israel Med. Asso. J. 4 2002 590 593
24. G. Schnyder, M. Roffi, Y. Flammer, R. Pin, and O.M. Hess Effect of homocysteine-lowering therapy with folic acid, vitamin B(12), and vitamin B(6) on clinical outcome after percutaneous coronary intervention: the Swiss Heart study: a randomized controlled trial JAMA 288 2002 939 973
25. W.H.H. Sheu, W.-J. Lee, and Y.-T. Chen Plasma homocysteine concentrations and insulin sensitivity in hypertensive subjects Am. J. Hypertens. 13 2000 14 20
26. W.H.H. Sheu, H.-S. Wu, C.-W. Wang, C.-J. Wan, and W.-J. Lee Elevated plasma homocysteine concentrations occur six months after gastroplasty in morbidly obese subjects Intern. Med. 40 2001 584 588
27. C.D. Stehouwer, M.A. Gall, P. Hougaard, C. Jakobs, and H.H. Parving Plasma homocysteine concentration predicts mortality in non-insulin-dependent diabetic patients with and without albuminuria Kidney Int. 55 1999 308 314
28. J.B. Ubbink, W.J. Hayward-Vermaak, and S. Bissbort Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum J. Chromatogr. 565 1991 441 446
29. M.C. Verhaar, R.M. Wever, J.J. Kastelein, T. van Dam, H.A. Koomans, and T.J. Rabelink 5-Methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia Circulation 97 1998 237 241
30. J.S. Volek, A.L. Gomez, D.M. Love, A.M. Weyers, R. Hesslink Jr., J.A. Wise, and W.J. Kraemer Effects of an 8-week weight-loss program on cardiovascular disease risk factors and regional body composition Europ. J. Clin. Nutrition 56 2002 585 592
31. A.W. Wahlefeld Triglyceride: determination after enzymatic hydrolysis H.U. Bergmeryer Methods of enzymatic analysis 1974 Academic Press New York 1831 1835
32. P. Ziccardi, F. Nappo, G. Giugliano, K. Esposito, R. Marfella, M. Cioffi, F. D'Andrea, A.M. Molinari, and D. Guigliano Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year Circulation 19 2002 804 809