Cotton rat tumor model for the evaluation of oncolytic adenoviruses

Human Gene Therapy

Volumn 16, Issue 1, 2005, Pages 139-146

  Toth, Karoly ^a   Spencer, Jacqueline F ^a   Tollefson, Ann E ^a   Kuppuswamy, Mohan ^a   Doronin, Konstantin ^a   Lichtenstein, Drew L ^a   La Regina, Marie C ^b   Prince, Gregory A ^c   Wold, William S M ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Virion Systems Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ONCOLYTIC VIRUS;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; FEMALE; IMMUNE DEFICIENCY; IMMUNOCOMPETENCE; IMMUNOGENICITY; NONHUMAN; RAT; TUMOR XENOGRAFT; VIRUS PARTICLE; VIRUS REPLICATION;

ADENOVIRUS INFECTIONS, HUMAN; ADENOVIRUSES, HUMAN; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; GENE THERAPY; GENETIC VECTORS; HUMANS; NEOPLASMS; RATS; SIGMODONTINAE; VIRUS REPLICATION;

EID: 13844253348     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.2005.16.139     Document Type: Article

References (24)

1. BERENCSI, K., URI, A., VALYI-NAGY, T., VALYI-NAGY, I., MEIGNIER, B., PERETZ, F.V., RANDO, R.F., PLOTKIN, S.A., and GONCZOL, E. (1994). Early region 3-replacement adenovirus recombinants are less pathogenic in cotton rats and mice than early region 3-deleted viruses. Lab. Invest. 71, 350-358.
2. COUCH, R.B., CHANOCK, R.M., CATE, T.R., LANG, D.J., KNIGHT, V., and HUEBNER, R.J. (1963). Immunization with types 4 and 7 adenovirus by selective infection of the intestinal tract. Am. Rev. Respir. Dis. 88(Suppl.), 394-403.
3. DORONIN, K., TOTH, K., KUPPUSWAMY, M., KRAJCSI, P., TOLLEFSON, A.E., and WOLD, W.S.M. (2003). Overexpression of the ADP (E3-11.6K) protein increases cell lysis and spread of adenovirus. Virology 305, 378-387.
4. EDMONDSON, W.P., PURCELL, R.H., GUNDELFINGER, B.F., LOVE, J.W., LUDWIG, W., and CHANOCK, R.M. (1966). Immunization by selective infection with type 4 adenovirus grown in human diploid tissue culture. II. specific protective effect against epidemic disease. JAMA 195, 453-459.
5. FAITH, R.E., MONTGOMERY, C.A., DURFEE, W.J., AGUILAR-CORDOVA, E., and WYDE, P.R. (1997). The cotton rat in biomedical research. Lab. Anim. Sci. 47, 337-345.
6. GINSBERG, H.S., LUNDHOLM-BEAUCHAMP, U., HORSWOOD, R.L., PERNIS, B., WOLD, W.S.M., CHANOCK, R.M., and PRINCE, G.A. (1989). Role of early region 3 (E3) in pathogenesis of adenovirus disease. Proc. Natl. Acad. Sci. U.S.A. 86, 3823-3827.
7. GUTEKUNST, R.R., WHITE, R.J., EDMONDSON, W.P., and CHANOCK, R.M. (1967). Immunization with live type 4 adenovirus: Determination of infectious virus dose and protective effect of enteric infection. Am. J. Epidemiol. 86, 341-349.
8. HALLDEN, G., HILL, R., WANG, Y.H., ANAND, A., LIU, T.C., LEMOINE, N.R., FRANCIS, J., HAWKINS, L., and KIRN, D. (2003). Novel immunocompetent murine tumor models for the assessment of replication-competent oncolytic adenovirus efficacy. Mol. Ther. 8, 412-424.
9. HARLOW, E., FRANZA, B.R.J., and SCHLEY, C. (1985). Monoclonal antibodies specific for adenovirus early region IA proteins: Extensive heterogeneity in early region 1A products. J. Virol. 55, 533-546.
10. LICHTENSTEIN, D.L., TOTH, K., DORONIN, K., TOLLEFSON A.E., and WOLD, W.S. (2004). Functions and mechanisms of action of the adenovirus E3 proteins. Int. Rev. Immunol. 23, 75-111.
11. MURPHY, T.F., DUBOVI, E.J., and CLYDE, W.A., JR. (1981). The cotton rat as an experimental model of human parainfluenza virus type 3 disease. Exp. Lung Res. 2, 97-109.
12. NAGAYAMA, Y., NAKAO, K., MIZUGUCHI, H., HAYAKAWA, T., and NIWA, M. (2003). Enhanced antitumor effect of combined replicative adenovirus and nonreplicative adenovirus expressing interleukin-12 in an immunocompetent mouse model. Gene Ther. 10, 1400-1403.
13. NIEWIESK, S., and PRINCE, G. (2002). Diversifying animal models: The use of hispid cotton rats (Sigmodon hispidus) in infectious diseases. Lab. Anim. 36, 357-372.
14. OUALIKENE, W., GONIN, P., and ELOIT, M. (1994). Short and long term dissemination of deletion mutants of adenovirus in permissive (cotton rat) and non-permissive (mouse) species. J. Gen. Virol. 75, 2765-2768.
15. PACINI, D.L., DUBOVI, E.J., and CLYDE, W.A., Jr. (1984). A new animal model for human respiratory tract disease due to adenovirus. J. Infect. Dis. 150, 92-97.
16. PRINCE, G.A., PORTER, D.A., JENSON, A.B., HORSWOLD, R.L., CHANOCK, R.M., and GINSBERG, H.S. (1993). Pathogenesis of adenovirus type 5 pneumonia in cotton rats (Sigmodon hispidus). J. Virol. 67, 101-111.
17. ROJAS-MARTINEZ, A., WYDE, P.R., MONTGOMERY, C.A., CHEN, S.H., WOO, S.L.C., and AGUILAR-CORDOVA, E. (1998). Distribution, persistency, toxicity, and lack of replication of an E1A-deficient adenoviral vector after intracardiac delivery in the cotton rat. Cancer Gene Ther. 5, 365-370.
18. SCHWARTZ, A.R., TOGO, Y., and HORNICK, R.B. (1974). Clinical evaluation of live, oral types 1, 2, and 5 adenovirus vaccines. Am. Rev. Respir. Dis. 109, 233-239.
19. TOLLEFSON, A.E., SCARIA, A., SAHA, S.K., and WOLD, W.S.M. (1992). The 11,600-MW protein encoded by region E3 of adenovirus is expressed early but is greatly amplified at late stages of infection. J. Virol. 66, 3633-3642.
20. TOLLEFSON, A.E., SCARIA, A., HERMISTON, T.W., RYERSE, J.S., WOLD, L.J., and WOLD, W.S.M. (1996). The adenovirus death protein (E3-11.6K) is required at very late stages of infection for efficient cell lysis and release of adenovirus from infected cells. J. Virol. 70, 2296-2306.
21. TOTH, K., DJEHA, H., YING, B.L., TOLLEFSON, A.E., KUPPUSWAMY, M., DORONIN, K., KRAJCSI, P., LIPINSKI, K., WRIGHTON, C.J., and WOLD, W.S.M. (2004). An oncolytic adenovirus vector combining enhanced cell-to-cell spreading, mediated by the ADP cytolytic protein, with selective replication in cancer cells with deregulated Wnt signaling. Cancer Res. 64, 3638-3644.
22. TSAI, J.C., GARLINGHOUSE, G., MCDONNELL, P.J., and TROUSDALE, M.D. (1992). An experimental animal model of adenovirus-induced ocular disease: The cotton rat. Arch. Ophthalmol. 110, 1167-1170.
23. WANG, Y.H., HALLDEN, G., HILL, R., ANAND, A., LIU, T.C., FRANCIS, J., BROOKS, G., LEMOINE, N., and KIRN, D. (2003). E3 gene manipulations affect oncolytic adenovirus activity in immunocompetent tumor models. Nat. Biotechnol. 21, 1328-1335.
24. WILDNER, O., and MORRIS, J.C. (2002). Subcutaneous administration of a replication-competent adenovirus expressing HSV-tk to cotton rats: Dissemination, persistence, shedding, and pathogenicity. Hum. Gene Ther. 13, 101-112.