Postoperative chemoradiotherapy after surgical resection of gastric adenocarcinoma: Can LV5FU2 reduce the toxic effects of the MacDonald regimen? A report on 23 patients

Gastroenterologie Clinique et Biologique

Volumn 29, Issue 1, 2005, Pages 11-15

  Dahan, Laetitia ^a   Atlan, Dan ^b   Bouché, Olivier ^c   Mitry, Emmanuel ^d   Ries, Pauline ^a   Artru, Pascal ^e   Richard, Karine ^a   Lledo, Gérard ^e   Nguyen, Tandat ^c   Rougier, Philippe ^d   Seitz, Jean François ^a  

^a TIMONE HOSPITAL   (France)

^b HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

^c SERVICE DE DERMATOLOGIE   (France)

^d ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^e Clinique Saint Jean   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; FOLINIC ACID;

ADULT; AGED; ANEMIA; ARTICLE; BLOOD TOXICITY; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; DIARRHEA; FEBRILE NEUTROPENIA; FEMALE; GASTRECTOMY; GASTROINTESTINAL TOXICITY; HUMAN; MALE; MUCOSA INFLAMMATION; MULTICENTER STUDY; NAUSEA; NEUTROPENIA; PHASE 3 CLINICAL TRIAL; POSTOPERATIVE PERIOD; RADIATION DOSE; STOMACH ADENOCARCINOMA; THROMBOCYTOPENIA; VOMITING;

EID: 13844250345     PISSN: 03998320     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0399-8320(05)80688-8     Document Type: Article

References (14)

1. Kelsen DP. Adjuvant and neoadjuvant therapy for gastric cancer. Semin Oncol 1996;23:379-89.
2. Hermans J, Bonenkamp JJ, Boon MC, Bunt AM, Ohyama S, Sasako M, et al. Adjuvant therapy after curative resection for gastric cancer: meta-analysis of randomized trials. J Clin Oncol 1993;11:1441-7.
3. Earle CC, Maroun JA. Adjuvant chemotherapy after curative resection for gastric cancer in non-Asian patients: revisiting a meta-analysis of randomised trials. Eur J Cancer 1999;35:1059-64.
4. Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med 2001;345:725-30.
5. de Gramont A, Bosset JF, Milan C, Rougier P, Bouche O, Etienne PL, et al. Randomized trial comparing monthly low-dose leucovorin and fluorouracil bolus with bimonthly high-dose leucovorin and fluorouracil bolus plus continuous infusion for advanced colorectal cancer: a French intergroup study. J Clin Oncol 1997;15:808-15.
6. Tournigand C, de Gramont A, Louvet C, André T, Carola E, Gilles-Amar V, et al. A simplified bi-monthly regimen with leucovorin (LV) and 5-fluorouracil (5FU) for metastatic colorectal cancer (MCRC) (abstract). Proc Am Soc Clin Oncol 1998;17:274.
7. Sobin LH, Wittekind CH. International Union Against Cancer (UICC). TNM classification of malignant tumors. 5th ed. New York: John Wiley & Sons, 1997.
8. Serlin O, Wolkoff JS, Amadeo JM, Keehn RJ. Use of 5-fluorodeoxyuridine (FUDR) as an adjuvant to the surgical management of carcinoma of the stomach. Cancer 1969;24:223-8.
9. Pignon JP, Ducreux M, Rougier P. Meta-analysis of adjuvant chemotherapy in gastric cancer: a critical reappraisal. J Clin Oncol 1994; 12:877-8.
10. Mari E, Floriani I, Tinazzi A, Buda A, Belfiglio M, Valentini M, et al. Efficacy of adjuvant chemotherapy after curative resection for gastric cancer: a meta-analysis of published randomised trials. A study of the GISCAD (Gruppo Italiano per lo Studio dei Carcinomi dell'Apparato Digerente). Ann Oncol 2000;11:837-43.
11. Zhang ZX, Gu XZ, Yin WB, Huang GJ, Zhang DW, Zhang RG. Randomized clinical trial on the combination of preoperative irradiation and surgery in the treatment of adenocarcinoma of gastric cardia (AGC) - report on 370 patients. Int J Radiat Oncol Biol Phys 1998;42:929-34.
12. Allum WH, Hallissey MT, Ward LC, Hockey MS. A controlled, prospective, randomised trial of adjuvant chemotherapy or radiotherapy in resectable gastric cancer: interim report. British Stomach Cancer Group. Br J Cancer 1989;60:739-44.
13. Recommandations de la Fédération Francophone de Cancérologie Di-gestive (FFCD). Que faire devant un cancer digestif en 2003? Gastroenterol Clin Biol 2002;26:1140-64.
14. Andre T, Colin P, Louvet C, et al. Toxicity report of a phase III trial (GERCOR C 96.1) comparing bimonthly LV5FU2 to monthly 5FU-leucovorin high dose (LV HD) in malades with Dukes B and C colon cancer (abstract). Proc Am Soc Clin Oncol 2000;19:256.