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Volumn 46, Issue 10, 2005, Pages 1597-1599

Palladium-catalysed arylation of sulfonamide stabilised enolates

Author keywords

Arylation; Palladium catalysis; Sulfonamide stabilised enolates

Indexed keywords

BENZYL DERIVATIVE; PALLADIUM; SODIUM DERIVATIVE; SULFONAMIDE; TOLUENE; TRIPHENYLPHOSPHINE;

EID: 13744252967     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.01.096     Document Type: Article
Times cited : (17)

References (19)
  • 8
    • 85030818117 scopus 로고    scopus 로고
    • 1,2,3,4-Tetrahydro-1-naphthalenamine Compounds Useful in Therapy
    • WO 00/51972; Pfizer Limited
    • Middleton, D. S.; Stobie, A. 1,2,3,4-Tetrahydro-1-naphthalenamine Compounds Useful in Therapy, Chem. Abstr. 133:222454, WO 00/51972; Pfizer Limited, 2000
    • (2000) Chem. Abstr. , vol.133 , pp. 222454
    • Middleton, D.S.1    Stobie, A.2
  • 18
    • 0035961019 scopus 로고    scopus 로고
    • 4 salt was used (available from Strem Chemicals); M.R. Netherton, and G.C. Fu Org. Lett. 3 2001 4295
    • (2001) Org. Lett. , vol.3 , pp. 4295
    • Netherton, M.R.1    Fu, G.C.2
  • 19
    • 85030818755 scopus 로고    scopus 로고
    • note
    • 2 (36 mg, 0.16 mmol, 8 mol %), triphenylphosphine (120 mg, 0.46 mmol, 23 mol %), 2-methoxynaphthalene (an accurately weighed amount as internal standard) and toluene (3 mL) were added. The tube was flushed with nitrogen and heated to 100-110°C in a Robosynthon multireactor for 15-20 h. The conversion of the methanesulfonamide and aryl bromide was determined by GLC analysis based on internal standard calculation. After a total reaction time of 15-20 h the reaction mixture was cooled and quenched by addition of water and dilute hydrochloric acid followed by extraction into ethyl acetate. After solvent removal, the residue was purified by column chromatography to afford the products


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.