Prospective, randomized trial examining the role of gentamycin-containing collagen sponge in the reduction of postoperative morbidity in rectal cancer patients: Early results and surprising outcome at 3-year follow-up

International Journal of Colorectal Disease

Volumn 20, Issue 2, 2005, Pages 114-120

  Nowacki, Marek P ^a   Rutkowski, Andrzej ^a   Olędzki, Janusz ^a   Chwaliński, Maciej ^a  

^a INSTITUTE OF ONCOLOGY   (Poland)

Author keywords

Collagen; Gentamycin; Postoperative complications; Rectal cancer; Survival

Indexed keywords

ANTINEOPLASTIC AGENT; CEFUROXIME; COLLAGEN; GENTAMICIN; LOW MOLECULAR WEIGHT HEPARIN; METRONIDAZOLE; STEROID;

ABDOMINAL ABSCESS; ADULT; AGED; ARTICLE; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER SURVIVAL; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEATH; FEMALE; FOLLOW UP; HUMAN; INTESTINE OBSTRUCTION; MAJOR CLINICAL STUDY; MALE; METASTASIS INHIBITION; MORBIDITY; OPERATION DURATION; PERITONITIS; POSTOPERATIVE COMPLICATION; POSTOPERATIVE INFECTION; POSTOPERATIVE PERIOD; POSTOPERATIVE THROMBOSIS; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; RECTUM CANCER; RESPIRATORY TRACT INFECTION; SAFETY; SURGICAL SPONGE; SURGICAL TECHNIQUE; TREATMENT OUTCOME; URINARY TRACT INFECTION; WOUND DEHISCENCE; WOUND INFECTION;

EID: 13644268444     PISSN: 01791958     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00384-004-0632-2     Document Type: Article

References (31)

1. Rullier E, Laurent C, Garrelon JL, Michel P, Saric J, Parneix M (1998) Risk factors for anastomotic leakage after resection of rectal cancer. Br J Surg 85:355-358. 10.1046/j.1365-2168.1998.00615.x
2. Fielding LP, Steward-Brown S, Belovsky L, Kearney G (1980) Anastomotic integrity after operations for large bowel cancer: A multicenter study. Br Med J 281:411-414. 1:STN:280:Bi6D2c7gtlQ%3D
3. Heald RJ, Leicester RJ (1981) The low stapled anastomosis. Br J Surg 68:333-337. 1:STN:280:Bi6C1crislY%3D
4. Tuson JRD, Everett WG (1990) A retrospective study of colostomies, leaks and strictures after colorectal anastomosis. Int J Colorectal Dis 5:44-48. 1:STN:280:By%2BC1cfgsF0%3D
5. Mealy K, Burke P, Hyland J (1992) Anterior resection without a defunctioning colostomy: Questions of safety. Br J Surg 79:305-307. 1:STN:280:By2B2cfjvFI%3D
6. Karanjia ND, Corder AP, Bearn P, Heald RJ (1994) Leakage from stapled low anastomosis after total mesorectal excision for carcinoma of the rectum. Br J Surg 81:1224-1226. 1:STN:280:ByqD2c7hs1A%3D
7. Pakkastie TE, Luukkonen PE, Jarvinen HJ (1994) Anastomotic leakage after anterior resection of the rectum. Eur J Surg 160:293-297. 1:STN:280:ByuA2Mrktlc%3D
8. Parc Y, Frileux P, Schmitt G, Dehni N, Ollivier JM, Parc R (2000) Management of postoperative peritonitis after anterior resection. Dis Colon Rectum 5:579-589
9. Carlsen E, Schlichting E, Guldvog I, Johnson E, Heald J (1998) Effect of the introduction of total mesorectal excision for the treatment of rectal cancer. Br J Surg 85:526-529 10.1046/j.1365-2168.1998.00601.x
10. Akyol AM, McGregor JR, Galloway DJ, Murray GD, George WD (1991) Anastomotic leaks in colorectal cancer surgery: A risk factor for recurrence? Int J Colorectal Dis 6:179-183
11. Petersen S, Freitag M, Hellmich G, Ludwig K (1998) Anastomotic leakage: impact on local recurrence and survival in surgery of colorectal cancer. Int J Colorectal Dis 13:160-163. 10.1007/s003840050158
12. Havenga K, Enker WE, Norstein J, Moriya Y, Heald RJ, van Houwelingen HC, van de Velde CJ (1999) Improved survival and local control after total mesorectal excision or D3 lymphadenectomy in the treatment of primary rectal cancer: An international analysis of 1411 patients. Eur J Surg Oncol 25:368-374. 10.1053/ejso.1999.0659
13. Glimelius B, Isacsson U, Jung B, Pahlman L (1997) Radiotherapy in addition to radical surgery in rectal cancer: Evidence for a dose-response effect favouring preoperative treatment. Int J Radiat Oncol Biol Phys 37:281-287. 10.1016/S0360-3016(96)00510-X
14. Killingback M, Barron P, Dent OF (2001) Local recurrence after curative resection of cancer of the rectum without total mesorectal excision. Dis Colon Rectum 44:473-483. 1:STN:280:DC%2BD3M3jvVGgsg%3D%3D
15. Heald RJ, Karanjia MB (1992) Results of radical surgery for rectal cancer. World J Surg 16:848-857. 1:STN:280:ByyD1MjntFI%3D
16. Heald RJ, Moran BJ, Ryall RDH, Sexton R, MacFarlane JK (1998) Rectal cancer. The Basingstoke experience of total mesorectal excision 1978-1997. Arch Surg 133:894-899. 10.1001/archsurg.133.8.894
17. Van de Velde CJH (2001) How mandatory is preoperative short-term radiotherapy in addition to total mesorectal excision for rectal cancer? In: Perspectives in colorectal cancer, 7-9 June 2001, Dublin, p 43
18. K Schäfer V Zumtobel E Rembs 1991 Liver resection and diffuse intra-abdominal bleeding In: A Stemberger R Ascherl F Lechner G Blümel (eds) Collagen as a drug carrier: Some applications in surgery Franklin Scientific UK 88-91
19. Stemberger A, Grimm H, Bader F, Rahn HD, Ascherl R (1997) Local treatment of bone and soft tissue infections with the collagen-gentamycin sponge. Eur J Surg Suppl 17-26
20. Mehta S, Humphrey JS, Schenkman DI, Seaber AV, Parker Vail T (1996) Gentamycin distribution from a collagen carrier. J Orthop Res 14:749-754. 1:STN:280:ByiD2cbgtlw%3D
21. Reynolds JV, Guillou PJ (1995) Immunology in general surgery. Curr Pract Surg 3:149-155
22. Rutten HJ, Nijhuis PH (1997) Prevention of wound infection in elective colorectal surgery by local application of gentamycin-containing collagen sponge. Eur J Surg Suppl 578:31-35. 9167147
23. HD Rahn 1991 Abdominoperineal rectum amputation - clinical results of the treatment of the presacral wound cavity with collagen with gentamycin In A Stemberger R Ascherl F Lechner G Blümel (eds) Collagen as a drug carrier: Some applications in surgery Franklin Scientific UK 92-95
24. Edwards LD (1976) The epidemiology of 2056 remote site infections and 1966 surgical wound infections occurring in 1865 patients: A four years study of 40,923 operations at Rush-Presbyterian-St. Luke's Hospital, Chicago. Ann Surg 184:758-766. 1:STN:280:CSiD28vmtFM%3D
25. Cruse PJ, Foord R (1973) A five-year prospective study of 23649 surgical wounds. Arch Surg 107:206-210. 1:STN:280:CSyB387ptFw%3D
26. Davidson AE, Clarc C, Smith G (1971) Postoperative wounds infection: A computer analysis. Br J Surg 58:333-337. 1:STN:280:CS6C1cnmtFA%3D
27. Vaneerdeweg W, Hendriks JM, Lauwers PR, Ieven M, Eyskens EJ (2000) Effect of gentamycin-containing sponges on the healing of colonic anastomoses in a rat model of peritonitis. Eur J Surg 12:959-962
28. Eriksen MT, Wibe A, Syse A, Haffner J, Wiig JN (2004) Inadvertent perforation during rectal cancer resection in Norway. Br J Surg 2:210-216 10.1002/bjs.4390
29. Nesbakken A, Nygaard K, Westerheim O, Lunde OC, Mala T (2002) Audit of intraoperative and early postoperative complications after introduction of mesorectal excision for rectal cancer. Eur J Surg 4:229-235
30. MA Scherer H Schlemmer J Scherer 1991 Evaluation of collagen with gentamycin in the treatment of soft tissue infections In: A Stemberger R Ascherl F Lechner G Blümel (eds.) Collagen as a drug carrier: Some applications in surgery Franklin Scientific UK 81-97
31. Kressner U, Graf W, Mahteme H, Pahlman L, Glimelius B 2002 Septic complications and prognosis after surgery for rectal cancer Dis Colon Rectum 45:316-321