Early treatment with pentoxifylline reduces lung injury induced by acid aspiration in rats

Chest

Volumn 127, Issue 2, 2005, Pages 613-621

  Pawlik, Michael T ^a   Schreyer, Andreas G ^a   Ittner, Karl P ^a   Selig, Christoph ^b   Gruber, Michael ^a   Feuerbach, Stefan ^a   Taeger, Kai ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY HOSPITAL ULM   (Germany)

Author keywords

Acute lung injury; Aspiration; Aspiration pneumonitis; CT; Pentoxifylline; Phosphodiesterase inhibitor; Pulmonary edema; Rats

Indexed keywords

HYDROCHLORIC ACID; PENTOBARBITAL; PENTOXIFYLLINE; PLACEBO; SEVOFLURANE; SODIUM CHLORIDE;

ARTERIAL BLOOD; ARTICLE; ARTIFICIAL VENTILATION; ASPIRATION PNEUMONIA; BLOOD GAS ANALYSIS; BLOOD PRESSURE REGULATION; CANNULATION; CONTROLLED STUDY; GAS EXCHANGE; HEART RATE; HEMODYNAMIC PARAMETERS; HYPOTENSION; LUNG INJURY; MALE; MORTALITY; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RAT; SURVIVAL; TRACHEOSTOMY; UNIVERSITY HOSPITAL;

EID: 13644257784     PISSN: 00123692     EISSN: None     Source Type: Journal    
DOI: 10.1378/chest.127.2.613     Document Type: Article

References (45)

1. Mendelson C. The aspiration of stomach contents into the lungs during obstetric anesthesia. Am J Obstet Gynecol 1946; 52:191-205
2. Exarhos N, Logan WJ, Abbott O, et al. The importance of pH and volume in tracheobronchial aspiration. Dis Chest 1965; 47:167-169
3. James CF, Modell JH, Gibbs CP, et al. Pulmonary aspiration: effects of volume and pH in the rat. Anesth Analg 1984; 63:665-668
4. Kennedy TP, Johnson KJ, Kunkel RG, et al. Acute acid aspiration lung injury in the rat: biphasic pathogenesis. Anesth Analg 1989; 69:87-92
5. Warner MA, Warner ME, Weber JG. Clinical significance of pulmonary aspiration during the perioperative period. Anesthesiology 1993; 78:56-62
6. Olsson GL, Hallen B, Hambraeus-Jonzon K. Aspiration during anaesthesia: a computer-aided study of 185,358 anaesthetics. Acta Anaesthesiol Scand 1986; 30:84-92
7. Folkesson HG, Matthay MA, Hebert CA, et al. Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms. J Clin Invest 1995; 96:107-116
8. Downey GP, Dong Q, Kruger J, et al. Regulation of neutrophil activation in acute lung injury. Chest 1999; 116:46S-54S
9. Davidson BA, Knight PR, Helinski JD, et al. The role of tumor necrosis factor-α in the pathogenesis of aspiration pneumonias in rats. Anesthesiology 1999; 91:486-499
10. Parsons PE, Moore FA, Moore EE, et al. Studies on the role of tumor necrosis factor in adult respiratory distress syndrome. Am Rev Respir Dis 1992; 146:694-700
11. Kudoh I, Ohtake M, Nishizawa H, et al. The effect of pentoxifylline on acid-induced alveolar epithelial injury. Anesthesiology 1995; 82:531-541
12. Kudoh I, Miyazaki H, Ohara M, et al. Activation of alveolar macrophages in acid-injured lung in rats: different effects of pentoxifylline on tumor necrosis factor-α and nitric oxide production. Crit Care Med 2001; 29:1621-1625
13. Montravers P, Fagon JY, Gilbert C, et al. Pilot study of cardiopulmonary risk from pentoxifylline in adult respiratory distress syndrome. Chest 1993; 103:1017-1022
14. Welsh CH, Lien D, Worthen GS, et al. Pentoxifylline decreases endotoxin-induced pulmonary neutrophil sequestration and extravascular protein accumulation in the dog. Am Rev Respir Dis 1988; 138:1106-1114
15. Seear MD, Hannam VL, Kaapa P, et al. Effect of pentoxifylline on hemodynamics, alveolar fluid reabsorption, and pulmonary edema in a model of acute lung injury. Am Rev Respir Dis 1990; 142:1083-1087
16. Bursten SL, Federighi DA, Parsons P, et al. An increase in serum C18 unsaturated free fatty acids as a predictor of the development of acute respiratory distress syndrome. Crit Care Med 1996; 24:1129-1136
17. The ARDS Clinical Trials Network. Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome. Crit Care Med 2002; 30:1-6
18. Desai SR. Acute respiratory distress syndrome: imaging of the injured lung. Clin Radiol 2002; 57:8-17
19. Gattinoni L, Caironi P, Pelosi P, et al. What has computed tomography taught us about the acute respiratory distress syndrome? Am J Respir Crit Care Med 2001; 164:1701-1711
20. Grasela DM, Rocci ML Jr. High-performance liquid chromatographic analysis of pentoxifylline and 1-(5′-hydroxyhexyl)-3,7-dimethylxanthine in whole blood. J Chromatogr 1987; 419:368-374
21. Wildberger JE, Niethammer MU, Klotz E, et al. Multi-slice CT for visualization of pulmonary embolism using perfusion weighted color maps. Rofo 2001; 173:289-294
22. Lehnert S, el-Khatib E. The use of CT densitometry in the assessment of radiation-induced damage to the rat lung: a comparison with other endpoints. Int J Radiat Oncol Biol Phys 1989; 16:117-124
23. Rouby JJ, Puybasset L, Nieszkowska A, et al. Acute respiratory distress syndrome: lessons from computed tomography of the whole lung. Crit Care Med 2003; 31:S285-S295
24. Cortijo J, Bou J, Beleta J, et al. Investigation into the role of phosphodiesterase IV in bronchorelaxation, including studies with human bronchus. Br J Pharmacol 1993; 108:562-568
25. Remy-Jardin M, Remy J, Giraud F, et al. Computed tomography assessment of ground-glass opacity: semiology and significance. J Thorac Imaging 1993; 8:249-264
26. Hedenstierna G, Lundquist H, Lundh B, et al. Pulmonary densities during anaesthesia: an experimental study on lung morphology and gas exchange. Eur Respir J 1989; 2:528-535
27. Austin JH, Muller NL, Friedman PJ, et al. Glossary of terms for CT of the lungs: recommendations of the Nomenclature Committee of the Fleischner Society. Radiology 1996; 200:327-331
28. Schreyer AG, Fielding JR, Warfield SK, et al. Virtual CT cystoscopy: color mapping of bladder wall thickness. Invest Radiol 2000; 35:331-334
29. Duggan M, McCaul CL, McNamara PJ, et al. Atelectasis causes vascular leak and lethal right ventricular failure in uninjured rat lungs. Am J Respir Crit Care Med 2003; 167:1633-1640
30. Yao Y, Yu Y, Peng Z, et al. [The effect of pentoxifylline on endotoxin-induced biopterin formation in rabbits]. Zhonghua Wai Ke Za Zhi 2000; 38:462-464
31. Wu CC, Liao MH, Chen SJ, et al. Pentoxifylline improves circulatory failure and survival in murine models of endotoxaemia. Eur J Pharmacol 1999; 373:41-49
32. Waxman K, Eloi L, Dinh L, et al. Pentoxifylline alone versus pentoxifylline combined with superoxide dismutase prolongs survival in a rat hemorrhagic shock model. Resuscitation 1993; 26:237-242
33. Bergman MR, Holycross BJ. Pharmacological modulation of myocardial tumor necrosis factor alpha production by phosphodiesterase inhibitors. J Pharmacol Exp Ther 1996; 279:247-254
34. Sliwa K, Woodiwiss A, Candy G, et al. Effects of pentoxifylline on cytokine profiles and left ventricular performance in patients with decompensated congestive heart failure secondary to idiopathic dilated cardiomyopathy. Am J Cardiol 2002; 90:1118-1122
35. Bernard GR, Artigas A, Brigham KL, et al. Report of the American-European Consensus conference on acute respiratory distress syndrome: definitions, mechanisms, relevant outcomes, and clinical trial coordination. J Crit Care 1994; 9:72-81
36. Rice G, Brown P, Nelson R, et al. Protection from endotoxic shock in mice by pharmacologic inhibition of phosphatidic acid. Proc Natl Acad Sci U S A 1994; 91:3857-3861
37. Abraham E, Bursten S, Shenkar R, et al. Phosphatidic acid signaling mediates lung cytokine expression and lung inflammatory injury after hemorrhage in mice. J Exp Med 1995; 181:569-575
38. George CL, Fantuzzi G, Bursten S, et al. Effects of lisofylline on hyperoxia-induced lung injury. Am J Physiol 1999; 276:L776-L785
39. Oka Y, Hasegawa N, Nakayama M, et al. Selective downregulation of neutrophils by a phosphatidic acid generation inhibitor in a porcine sepsis model. J Surg Res 1999; 81:147-155
40. Moriuchi H, Yuizono T. Pentoxifylline prevents a decrease in arterial oxygen tension in oleic acid-induced lung injury. Crit Care Med 1995; 23:357-364
41. Frank JA, Gutierrez JA, Jones KD, et al. Low tidal volume reduces epithelial and endothelial injury in acid-injured rat lungs. Am J Respir Crit Care Med 2002; 165:242-249
42. Teabeaut J. Aspiration of gastric contents: an experimental study. Am J Pathol 1952; 28:28-51
43. Schwartz DJ, Wynne JW, Gibbs CP, et al. The pulmonary consequences of aspiration of gastric contents at pH values greater than 2.5. Am Rev Respir Dis 1980; 121:119-126
44. Marik PE. Aspiration pneumonias and aspiration pneumonia. N Engl J Med 2001; 344:665-671
45. Knight PR, Kurek C, Davidson BA, et al. Acid aspiration increases sensitivity to increased ambient oxygen concentrations. Am J Physiol Lung Cell Mol Physiol 2000; 278:L1240-L1247