메뉴 건너뛰기




Volumn 6, Issue 4, 2004, Pages 226-233

Protease-inhibitor boosting in the treatment-experienced patient

Author keywords

Boosting; Pharmacokinetics; Protease inhibitor; Ritonavir

Indexed keywords

ABACAVIR; AMPRENAVIR; AMPRENAVIR PHOSPHATE; ANTIRETROVIRUS AGENT; ATAZANAVIR; CHOLESTEROL; CYTOCHROME P450 3A4; INDINAVIR; LAMIVUDINE; LOPINAVIR; NELFINAVIR; PROTEINASE INHIBITOR; RITONAVIR; SAQUINAVIR; TENOFOVIR; TRIACYLGLYCEROL;

EID: 13644249455     PISSN: 11396121     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (28)

References (52)
  • 1
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection
    • Palella F, Delaney K, Moorman A, et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N Engl J Med 1998:338:853-60.
    • (1998) N. Engl. J. Med. , vol.338 , pp. 853-860
    • Palella, F.1    Delaney, K.2    Moorman, A.3
  • 2
    • 0037055025 scopus 로고    scopus 로고
    • Antiretroviral treatment for adult HIV infection in 2002: Updated recommendations of the International AIDS Society-USA Panel
    • Yeni P, Hammer S, Carpenter C, et al. Antiretroviral treatment for adult HIV infection in 2002: updated recommendations of the International AIDS Society-USA Panel. JAMA 2002:288:222-35.
    • (2002) JAMA , vol.288 , pp. 222-235
    • Yeni, P.1    Hammer, S.2    Carpenter, C.3
  • 3
    • 0037192582 scopus 로고    scopus 로고
    • Improved long-term suppression of HIV-1 replication with a triple-class multidrug regimen compared with standard of care antiretroviral therapy
    • Van Praag R, Wit F, Jurriaans S, De Wolf F, Prins J, Lange J. Improved long-term suppression of HIV-1 replication with a triple-class multidrug regimen compared with standard of care antiretroviral therapy. AIDS 2002;16:719-25.
    • (2002) AIDS , vol.16 , pp. 719-725
    • Van Praag, R.1    Wit, F.2    Jurriaans, S.3    De Wolf, F.4    Prins, J.5    Lange, J.6
  • 4
    • 0031751330 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and interactions with other anti-HIV agents
    • Hsu A, Granneman G, Bertz R. Ritonavir. Clinical pharmacokinetics and interactions with other anti-HIV agents. Clin Pharmacokinet 1998;35:275-91.
    • (1998) Clin. Pharmacokinet. , vol.35 , pp. 275-291
    • Hsu, A.1    Granneman, G.2    Bertz, R.3    Ritonavir, A.4
  • 5
    • 0035117801 scopus 로고    scopus 로고
    • Use of HIV protease inhibitors as pharmacoenhancers
    • Moyle G. Use of HIV protease inhibitors as pharmacoenhancers. AIDS Read 2001;11:87-98.
    • (2001) AIDS Read , vol.11 , pp. 87-98
    • Moyle, G.1
  • 6
    • 0037339136 scopus 로고    scopus 로고
    • The role of pharmacological enhancement in protease inhibitor-based highly active antiretroviral therapy
    • Becker S. The role of pharmacological enhancement in protease inhibitor-based highly active antiretroviral therapy. Expert Opin Investig Drugs 2003:12:401-12.
    • (2003) Expert. Opin. Investig. Drugs , vol.12 , pp. 401-412
    • Becker, S.1
  • 7
    • 0034455640 scopus 로고    scopus 로고
    • Using pharmacokinetics to optimize antiretroviral drug-drug interactions in the treatment of human immunodeficiency virus infection
    • Gerber J. Using pharmacokinetics to optimize antiretroviral drug-drug interactions in the treatment of human immunodeficiency virus infection. Clin Infect Dis 2000;30 Suppl 2:123-9.
    • (2000) Clin. Infect. Dis. , vol.30 , Issue.SUPPL. 2 , pp. 123-129
    • Gerber, J.1
  • 8
    • 0037871892 scopus 로고    scopus 로고
    • A review of low-dose ritonavir in protease inhibitor combination therapy
    • Cooper C, Van Heeswijk R, Gallicano K, Cameron D. A review of low-dose ritonavir in protease inhibitor combination therapy. Clin Infect Dis 2003;36:1585-92.
    • (2003) Clin. Infect. Dis. , vol.36 , pp. 1585-1592
    • Cooper, C.1    Van Heeswijk, R.2    Gallicano, K.3    Cameron, D.4
  • 9
    • 0032971472 scopus 로고    scopus 로고
    • Ritonavir and saquinavir combination therapy for the treatment of HIV infection
    • Cameron D, Japour A, Xu Y, et al. Ritonavir and saquinavir combination therapy for the treatment of HIV infection. AIDS 1999;13:213-24.
    • (1999) AIDS , vol.13 , pp. 213-224
    • Cameron, D.1    Japour, A.2    Xu, Y.3
  • 10
    • 0042945648 scopus 로고    scopus 로고
    • Steady-state pharmacokinetic interaction study between BMS-232632 and ritonavir in healthy subjects
    • 8th CROI; February Chicago (IL) [abstract 740]
    • O'Mara E, Mummaneni V, Bifano M, et al. Steady-state pharmacokinetic interaction study between BMS-232632 and ritonavir in healthy subjects. 8th CROI; February 2001; Chicago (IL) [abstract 740].
    • (2001)
    • O'Mara, E.1    Mummaneni, V.2    Bifano, M.3
  • 11
    • 0041944069 scopus 로고    scopus 로고
    • Steady-state pharmacokinetic (PK) interaction study of atazanavir (ATV) with ritonavir (RTV) in healthy subjects
    • 42nd ICAAC; September San Diego (CA). Abstract Book. Herndon, VA: ASM Press; [abstract H-1716]
    • Agarwala S, Russo R, Mummaneni V, Randall D, Geraldes M, O'Mara E. Steady-state pharmacokinetic (PK) interaction study of atazanavir (ATV) with ritonavir (RTV) in healthy subjects. 42nd ICAAC; September 2002; San Diego (CA). Abstract Book. Herndon, VA: ASM Press; 274 [abstract H-1716].
    • (2002) , pp. 274
    • Agarwala, S.1    Russo, R.2    Mummaneni, V.3    Randall, D.4    Geraldes, M.5    O'Mara, E.6
  • 12
    • 13644265237 scopus 로고    scopus 로고
    • Bristol-Myers Squibb Company. BMS-232632: Atazanavir Briefing Document May, 2003. Accessed March 22
    • Bristol-Myers Squibb Company. BMS-232632: Atazanavir Briefing Document May, 2003. http://www.fda.gov/ohrms/dockets/ac/03/briefing/ 3950B1_01_bristolmyerssquibb-atazanavir.pdf. Accessed March 22, 2004.
    • (2004)
  • 14
    • 0034027217 scopus 로고    scopus 로고
    • Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population
    • Bangsberg D, Hecht F, Charlebois E, et al. Adherence to protease inhibitors, HIV-1 viral load, and development of drug resistance in an indigent population. AIDS 2000;14:357-66.
    • (2000) AIDS , vol.14 , pp. 357-366
    • Bangsberg, D.1    Hecht, F.2    Charlebois, E.3
  • 15
    • 0142218458 scopus 로고    scopus 로고
    • Association between adherence to antiretroviral therapy and human immunodeficiency virus drug resistance
    • Sethi A, Celentano D, Gange S, Moore R, Gallant J. Association between adherence to antiretroviral therapy and human immunodeficiency virus drug resistance. Clin Infect Dis 2003;37:1112-8.
    • (2003) Clin. Infect. Dis. , vol.37 , pp. 1112-1118
    • Sethi, A.1    Celentano, D.2    Gange, S.3    Moore, R.4    Gallant, J.5
  • 16
    • 0036895440 scopus 로고    scopus 로고
    • Virtual inhibitory quotient predicts response to ritonavir boosting of indinavir-based therapy in human immunodeficiency virus-infected patients with ongoing viremia
    • Shulman N, Zolopa A, Havlir D, et al. Virtual inhibitory quotient predicts response to ritonavir boosting of indinavir-based therapy in human immunodeficiency virus-infected patients with ongoing viremia. Antimicrob Agents Chemother 2002;46:3907-16.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 3907-3916
    • Shulman, N.1    Zolopa, A.2    Havlir, D.3
  • 17
    • 0037308542 scopus 로고    scopus 로고
    • Genotypic inhibitory quotient as predictor of virological response to ritonavir-amprenavir in human immunodeficiency virus type 1 protease inhibitor-experienced patients
    • and the Genophar Study Group
    • Marcelin A, Lamotte C, Delaugerre C, et al., and the Genophar Study Group. Genotypic inhibitory quotient as predictor of virological response to ritonavir-amprenavir in human immunodeficiency virus type 1 protease inhibitor-experienced patients. Antimicrob Agents Chemother 2003;47:594-600.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 594-600
    • Marcelin, A.1    Lamotte, C.2    Delaugerre, C.3
  • 18
    • 1642389500 scopus 로고    scopus 로고
    • Characterization of the impact of genotype, phenotype, and inhibitory quotient on antiviral activity of tipranavir in highly treatment-experienced patients
    • [abstract 12]
    • McCallister S, Kohlbrenner V, Squires K, et al. Characterization of the impact of genotype, phenotype, and inhibitory quotient on antiviral activity of tipranavir in highly treatment-experienced patients. Antivir Ther 2003;8 Suppl 1:15[abstract 12].
    • (2003) Antivir. Ther. , vol.8 , Issue.SUPPL. 1 , pp. 15
    • McCallister, S.1    Kohlbrenner, V.2    Squires, K.3
  • 19
    • 9144271024 scopus 로고    scopus 로고
    • Incidence of resistance in a double-blind study comparing lopinavir/ritonavir plus stavudine and lamivudine to nelfinavir plus stavudine and lamivudine
    • Kempf D, King M, Bernstein B, et al. Incidence of resistance in a double-blind study comparing lopinavir/ritonavir plus stavudine and lamivudine to nelfinavir plus stavudine and lamivudine. J Infect Dis 2004;189:51-60.
    • (2004) J. Infect. Dis. , vol.189 , pp. 51-60
    • Kempf, D.1    King, M.2    Bernstein, B.3
  • 20
    • 0038360368 scopus 로고    scopus 로고
    • GW433908 in ART-naive subjects: Absence of resistance at 48 weeks with boosted regimen and APV-like resistance profile with unboosted regimen
    • 10th CROI; February Boston (MA) [abstract 598]
    • Macmanus S, Yates P, White S, Richards N, Snowden W. GW433908 in ART-naive subjects: absence of resistance at 48 weeks with boosted regimen and APV-like resistance profile with unboosted regimen. 10th CROI; February 2003; Boston (MA) [abstract 598].
    • (2003)
    • Macmanus, S.1    Yates, P.2    White, S.3    Richards, N.4    Snowden, W.5
  • 21
    • 0034906186 scopus 로고    scopus 로고
    • Disorders of lipid metabolism in patients with HIV disease treated with antiretroviral agents: Frequency, relationship with administered drugs, and role of hypolipidemic therapy with bezafibrate
    • Manfredi R, Chiodo F. Disorders of lipid metabolism in patients with HIV disease treated with antiretroviral agents: frequency, relationship with administered drugs, and role of hypolipidemic therapy with bezafibrate. J Infect 2001;42:181-8.
    • (2001) J. Infect. , vol.42 , pp. 181-188
    • Manfredi, R.1    Chiodo, F.2
  • 22
    • 0033873920 scopus 로고    scopus 로고
    • Hyperlipidemia associated with HIV protease inhibitor use: Pathophysiology, prevalence, risk factors and treatment
    • Penzak S, Chuck S. Hyperlipidemia associated with HIV protease inhibitor use: pathophysiology, prevalence, risk factors and treatment. Scand J Infect Dis 2000;32:111-23.
    • (2000) Scand. J. Infect. Dis. , vol.32 , pp. 111-123
    • Penzak, S.1    Chuck, S.2
  • 23
    • 0035461510 scopus 로고    scopus 로고
    • Saquinavir and ritonavir pharmacokinetics following combined ritonavir and saquinavir (soft gelatin capsules) administration
    • Buss N, Snell P, Bock J, Hsu A, Jorge K. Saquinavir and ritonavir pharmacokinetics following combined ritonavir and saquinavir (soft gelatin capsules) administration. Br J Clin Pharmacol 2001; 52:255-64.
    • (2001) Br. J. Clin. Pharmacol. , vol.52 , pp. 255-264
    • Buss, N.1    Snell, P.2    Bock, J.3    Hsu, A.4    Jorge, K.5
  • 24
    • 0013309175 scopus 로고    scopus 로고
    • Continued indinavir vs. switching to indinavir/ritonavir in HIV-infected patients with suppressed viral load
    • for the BEST Study Team
    • Arnaiz J, Mallolas J, Podzamczer D, et al., for the BEST Study Team. Continued indinavir vs. switching to indinavir/ritonavir in HIV-infected patients with suppressed viral load. AIDS 2003;17:831-40.
    • (2003) AIDS , vol.17 , pp. 831-840
    • Arnaiz, J.1    Mallolas, J.2    Podzamczer, D.3
  • 25
    • 17044457456 scopus 로고    scopus 로고
    • Lopinavir plasma concentrations and changes in lipid levels during salvage therapy with lopinavir/ritonavir-containing regimens
    • Gutiérrez F, Padilla S, Navarro A, et al. Lopinavir plasma concentrations and changes in lipid levels during salvage therapy with lopinavir/ritonavir-containing regimens. J Acquir Immune Defic Syndr 2003;33:594-600.
    • (2003) J. Acquir. Immune Defic. Syndr. , vol.33 , pp. 594-600
    • Gutiérrez, F.1    Padilla, S.2    Navarro, A.3
  • 26
    • 0006843725 scopus 로고    scopus 로고
    • A randomized study comparing continued indinavir (800 mg tid) vs. switching to indinavir/ritonavir (800/100 mg bid) in HIV patients having achieved viral load suppression with indinavir plus 2 nucleoside analogues
    • The Bid Efficacy and Safety Trial (BEST). XIII International AIDS Conference Barcelona [abstract WeOrB484]
    • Gatell J, Lange J, Arnaiz J, Faetkenheuer G, Mallolas J, Clotet B. A randomized study comparing continued indinavir (800 mg tid) vs. switching to indinavir/ritonavir (800/100 mg bid) in HIV patients having achieved viral load suppression with indinavir plus 2 nucleoside analogues. The Bid Efficacy and Safety Trial (BEST). XIII International AIDS Conference; 2000; Barcelona [abstract WeOrB484].
    • (2000)
    • Gatell, J.1    Lange, J.2    Arnaiz, J.3    Faetkenheuer, G.4    Mallolas, J.5    Clotet, B.6
  • 27
    • 0036499067 scopus 로고    scopus 로고
    • Safety and antiviral activity at 48 weeks of lopinavir/ritonavir plus nevirapine and 2 nucleoside reverse-transcriptase inhibitors in human immunodeficiency virus type 1-infected protease inhibitor-experienced patients
    • Benson C, Deeks S, Brun S, et al. Safety and antiviral activity at 48 weeks of lopinavir/ritonavir plus nevirapine and 2 nucleoside reverse-transcriptase inhibitors in human immunodeficiency virus type 1-infected protease inhibitor-experienced patients. J Infect Dis 2002;185:599-607.
    • (2002) J. Infect. Dis. , vol.185 , pp. 599-607
    • Benson, C.1    Deeks, S.2    Brun, S.3
  • 28
    • 0002472332 scopus 로고    scopus 로고
    • Durable suppression of HIV+ RNA after 2 years of therapy with ABT-378/ritonavir (ABT-378/r) treatment in single protease inhibitor experienced patients
    • for the M97-765 Study Group. [abstract P101]
    • Feinberg J, Brun S, Xu Y, et al., for the M97-765 Study Group. Durable suppression of HIV+ RNA after 2 years of therapy with ABT-378/ritonavir (ABT-378/r) treatment in single protease inhibitor experienced patients. AIDS 2000;14 Suppl 4:46[abstract P101].
    • (2000) AIDS , vol.14 , Issue.SUPPL. 4 , pp. 46
    • Feinberg, J.1    Brun, S.2    Xu, Y.3
  • 29
    • 0005678653 scopus 로고    scopus 로고
    • Kaletra (lopinavir/ritonavir) and efavirenz: 72 week safety/efficacy evaluation and phenotypic/genotypic breakpoints in multiple PI experienced patients
    • 41st ICAAC; December Chicago (IL) [abstract 344]. [abstract I-1925]
    • Danner S, Brun S, Sylte J, et al. Kaletra (lopinavir/ritonavir) and efavirenz: 72 week safety/efficacy evaluation and phenotypic/genotypic breakpoints in multiple PI experienced patients [abstract I-1925]. 41st ICAAC; December 2001; Chicago (IL) [abstract 344].
    • (2001)
    • Danner, S.1    Brun, S.2    Sylte, J.3
  • 30
    • 0035986072 scopus 로고    scopus 로고
    • Salvage treatment with lopinavir/ritonavir (Kaletra) in HIV-infected patients failing all current antiretroviral drug families
    • De Mendoza C, Martín-Carbonero L, Barreiro P, et al. Salvage treatment with lopinavir/ritonavir (Kaletra) in HIV-infected patients failing all current antiretroviral drug families. HIV Clin Trials 2002;3:304-9.
    • (2002) HIV Clin. Trials , vol.3 , pp. 304-309
    • De Mendoza, C.1    Martín-Carbonero, L.2    Barreiro, P.3
  • 31
    • 0037114877 scopus 로고    scopus 로고
    • Open-label study of a twice-daily indinavir 800 mg/ritonavir 200 mg regimen in HIV-infected adults failing a protease inhibitor regimen
    • Katner H, Paar D, Nadler J, et al. Open-label study of a twice-daily indinavir 800 mg/ritonavir 200 mg regimen in HIV-infected adults failing a protease inhibitor regimen. J Acquir Immune Defic Syndr 2002;31:483-7.
    • (2002) J. Acquir. Immune Defic. Syndr. , vol.31 , pp. 483-487
    • Katner, H.1    Paar, D.2    Nadler, J.3
  • 32
    • 13644262930 scopus 로고    scopus 로고
    • Indinavir tid vs. indinavir/ritonavir bid in combination with AZT/3TC for HIV infection in nucleoside pretreated patients: HIV-NAT 005 76-week follow up
    • 9th CROI; February Seattle (WA) [poster 422-W]
    • Boyd M, Duncombe C, Ruxrungthram K, et al. Indinavir tid vs. indinavir/ritonavir bid in combination with AZT/3TC for HIV infection in nucleoside pretreated patients: HIV-NAT 005 76-week follow up. 9th CROI; February 2002; Seattle (WA) [poster 422-W].
    • (2002)
    • Boyd, M.1    Duncombe, C.2    Ruxrungthram, K.3
  • 33
    • 27344437653 scopus 로고    scopus 로고
    • Final analysis of a randomized trial to evaluate safety and efficacy of indinavir/ritonavir versus saquinavir/ritonavir in adult HIV-1 infection: The MaxCmin1 Trial
    • 42nd ICAAC; September San Diego (CA) [abstract H-172]
    • Gerstoft J, Dragsted U, Cahn P, et al. Final analysis of a randomized trial to evaluate safety and efficacy of indinavir/ritonavir versus saquinavir/ritonavir in adult HIV-1 infection: the MaxCmin1 Trial. 42nd ICAAC; September 2002; San Diego (CA) [abstract H-172].
    • (2002)
    • Gerstoft, J.1    Dragsted, U.2    Cahn, P.3
  • 34
    • 0038575809 scopus 로고    scopus 로고
    • Saquinavir: A review of its use in boosted regimens for treating HIV infection
    • Plosker G, Scott L. Saquinavir: a review of its use in boosted regimens for treating HIV infection. Drugs 2003;63:1299-324.
    • (2003) Drugs , vol.63 , pp. 1299-1324
    • Plosker, G.1    Scott, L.2
  • 35
    • 0141612910 scopus 로고    scopus 로고
    • Randomized trial to evaluate indinavir/ritonavir vs. saquinavir/ritonavir in human immunodeficiency virus type 1-infected patients: The MaxCmin1 Trial
    • for the MaxCmin1 Trial Group
    • Dragsted U, Gerstoft J, Pedersen C, et al., for the MaxCmin1 Trial Group. Randomized trial to evaluate indinavir/ritonavir vs. saquinavir/ritonavir in human immunodeficiency virus type 1-infected patients: the MaxCmin1 Trial. J Infect Dis 2003;188:635-42.
    • (2003) J. Infect. Dis. , vol.188 , pp. 635-642
    • Dragsted, U.1    Gerstoft, J.2    Pedersen, C.3
  • 36
    • 22844439930 scopus 로고    scopus 로고
    • The final week 48 analysis of a phase IV, randomised, open-label, multi-centre trial to evaluate safety and efficacy of lopinavir/ritonavir (400/100 mg bid) vs. saquinavir/ritonavir (1000/100 mg bid) in adult HIV-1 infection: The MaxCmin2 Trial
    • 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment; July Paris [poster LB23]
    • Youle M, Gerstoft J, Fox Z, et al. The final week 48 analysis of a phase IV, randomised, open-label, multi-centre trial to evaluate safety and efficacy of lopinavir/ritonavir (400/100 mg bid) vs. saquinavir/ritonavir (1000/100 mg bid) in adult HIV-1 infection: the MaxCmin2 Trial. 2nd International AIDS Society Conference on HIV Pathogenesis and Treatment; July 2003; Paris [poster LB23].
    • (2003)
    • Youle, M.1    Gerstoft, J.2    Fox, Z.3
  • 37
    • 22844439930 scopus 로고    scopus 로고
    • The final week 48 analysis of a phase IV, randomised, open-label, multi-center trial to evaluate safety and efficacy of lopinavir/ritonavir (400/100 mg bid) vs. saquinavir/ritonavir (1000/100 mg bid): The MaxCMin2 Trial
    • 9th European AIDS Conference (EACS); October Warsaw [abstract F11/3]
    • Youle M, Gerstoft J, Fox Z, et al. The final week 48 analysis of a phase IV, randomised, open-label, multi-center trial to evaluate safety and efficacy of lopinavir/ritonavir (400/100 mg bid) vs. saquinavir/ritonavir (1000/100 mg bid): The MaxCMin2 Trial. 9th European AIDS Conference (EACS); October 2003; Warsaw [abstract F11/3].
    • (2003)
    • Youle, M.1    Gerstoft, J.2    Fox, Z.3
  • 38
    • 13644258146 scopus 로고    scopus 로고
    • Lipid profiles of patients enrolled in the MaxCmin 2 trial: A randomized, open-label multicenter comparative trial evaluating the safety and efficacy of lopinavir/ritonavir (400/100 mg twice daily) vs. saquinavir/ritonavir SQV/r (1000/100 mg twice daily)
    • 11th CROI; February San Francisco (CA) [abstract 720]
    • Walmsley S, Benetucci J, Brutus A, et al. Lipid profiles of patients enrolled in the MaxCmin 2 trial: a randomized, open-label multicenter comparative trial evaluating the safety and efficacy of lopinavir/ritonavir (400/100 mg twice daily) vs. saquinavir/ritonavir SQV/r (1000/100 mg twice daily). 11th CROI; February 2004, San Francisco (CA) [abstract 720].
    • (2004)
    • Walmsley, S.1    Benetucci, J.2    Brutus, A.3
  • 39
    • 2442681710 scopus 로고    scopus 로고
    • Twice-daily amprenavir 1200 mg vs. amprenavir 600 mg/ ritonavir 100 mg, in combination with at least 2 other antiretroviral drugs, in HIV-1-infected patients
    • and the ESS40011 (STARR) Study Team
    • Nadler J, Gathe J, Pollard R, et al., and the ESS40011 (STARR) Study Team. Twice-daily amprenavir 1200 mg vs. amprenavir 600 mg/ ritonavir 100 mg, in combination with at least 2 other antiretroviral drugs, in HIV-1-infected patients. BMC Infect Dis 2003;3:10.
    • (2003) BMC Infect. Dis. , vol.3 , pp. 10
    • Nadler, J.1    Gathe, J.2    Pollard, R.3
  • 40
    • 13644256506 scopus 로고    scopus 로고
    • Efficacy, safety and amprenavir (APV) pharmacokinetic (PK) responses of twice-daily APV and ritonavir (RTV) regimens in HIV-1 infected treatment-experienced adults for 48 weeks (ESS40006)
    • 41st ICAAC; September Chicago (IL) [abstract 344]
    • Schooley R, Haubrich R, Sension M, et al. Efficacy, safety and amprenavir (APV) pharmacokinetic (PK) responses of twice-daily APV and ritonavir (RTV) regimens in HIV-1 infected treatment-experienced adults for 48 weeks (ESS40006). 41st ICAAC; September 2001; Chicago (IL) [abstract 344].
    • (2001)
    • Schooley, R.1    Haubrich, R.2    Sension, M.3
  • 41
    • 0003351767 scopus 로고    scopus 로고
    • Amprenavir (APV) 600 mg/ritonavir (RTV) 100 mg bid or APV 1200 mg/RTV 200 mg qd given in combination with abacavir (ABC) and lamivudine (3TC) maintains efficacy in ART naive HIV-1 infected adults over 12 weeks (APV20001)
    • 8th CROI; February Chicago (IL) [abstract 332]
    • Wood R, Trepo C, Livrozet J, et al. Amprenavir (APV) 600 mg/ritonavir (RTV) 100 mg bid or APV 1200 mg/RTV 200 mg qd given in combination with abacavir (ABC) and lamivudine (3TC) maintains efficacy in ART naive HIV-1 infected adults over 12 weeks (APV20001). 8th CROI; February 2001; Chicago (IL) [abstract 332].
    • (2001)
    • Wood, R.1    Trepo, C.2    Livrozet, J.3
  • 42
    • 0008644635 scopus 로고    scopus 로고
    • Amprenavir (APV) 600 mg/ritonavir (RTV) 100 mg bid or APV 1.200 mg/RTV 200 mg qd given in combination with abacavir (ABC) and lamivudine (3TC) maintains efficacy in ART naive HIV-1 infected adults over 24-weeks (APV20001)
    • 8th European Conference on Clinical Aspects and Treatment of HIV Infection; October Athens [abstract P218]
    • Arasteh K, Wood R, Teofilo E, et al. Amprenavir (APV) 600 mg/ritonavir (RTV) 100 mg bid or APV 1.200 mg/RTV 200 mg qd given in combination with abacavir (ABC) and lamivudine (3TC) maintains efficacy in ART naive HIV-1 infected adults over 24-weeks (APV20001). 8th European Conference on Clinical Aspects and Treatment of HIV infection; October 2001; Athens [abstract P218].
    • (2001)
    • Arasteh, K.1    Wood, R.2    Teofilo, E.3
  • 43
    • 0037684348 scopus 로고    scopus 로고
    • The Context study: Efficacy and safety of GW433908/RTV in PI-experienced subjects with virological failure (24 week results)
    • 10th CROI; February Boston (MA) [abstract 178]
    • DeJesus E, LaMarca A, Sension M, Beltrán C, Yeni P. The Context study: efficacy and safety of GW433908/RTV in PI-experienced subjects with virological failure (24 week results). 10th CROI; February 2003; Boston (MA) [abstract 178].
    • (2003)
    • DeJesus, E.1    LaMarca, A.2    Sension, M.3    Beltrán, C.4    Yeni, P.5
  • 44
    • 1642370571 scopus 로고    scopus 로고
    • Vertex reports preliminary 48-week data from phase III study of 433908, an investigational HIV protease inhibitor
    • Vertex Pharmaceuticals Incorporated. Press release. Press release dated July 24, 2003. Available at: www.vpharm.com/Pressreleases2003/pr072403.html. Accessed June 4
    • Vertex Pharmaceuticals Incorporated. Vertex reports preliminary 48-week data from phase III study of 433908, an investigational HIV protease inhibitor. Press release. Press release dated July 24, 2003. Available at: www.vpharm.com/Pressreleases2003/pr072403.html. Accessed June 4, 2004.
    • (2004)
  • 45
    • 3142662261 scopus 로고    scopus 로고
    • Efficacy and safety of atazanavir with ritonavir or saquinavir vs. lopinavir/ritonavir in patients who have experienced virologic failure on multiple HAART regimens: 48-week results from BMS A1424-045
    • 11th CROI; February San Francisco (CA) [abstract 547]
    • DeJesus E, Grinsztejn B, Rodríguez C, et al. Efficacy and safety of atazanavir with ritonavir or saquinavir vs. lopinavir/ritonavir in patients who have experienced virologic failure on multiple HAART regimens: 48-week results from BMS A1424-045. 11th CROI; February 2004; San Francisco (CA) [abstract 547].
    • (2004)
    • DeJesus, E.1    Grinsztejn, B.2    Rodríguez, C.3
  • 46
    • 13644269030 scopus 로고    scopus 로고
    • Safety assessment of patients receiving atazanavir (9ATV) with ritonavir (RTV), ATV with saquinavir (SQV), or lopinavir (LPV)/RTV: 48-week results from BMS A1424-045
    • 13th International Symposium on HIV & Emerging Infectious Diseases; June Toulon, France [abstract PP 4.57]
    • Clotet B, Lazzarin A, Grinsztejn B, Lichtenstein K, Sankoh S, Wilber R. Safety assessment of patients receiving atazanavir (9ATV) with ritonavir (RTV), ATV with saquinavir (SQV), or lopinavir (LPV)/RTV: 48-week results from BMS A1424-045. 13th International Symposium on HIV & Emerging Infectious Diseases; June 2004, Toulon, France [abstract PP 4.57].
    • (2004)
    • Clotet, B.1    Lazzarin, A.2    Grinsztejn, B.3    Lichtenstein, K.4    Sankoh, S.5    Wilber, R.6
  • 47
    • 0037234238 scopus 로고    scopus 로고
    • Results of a phase 2 clinical trial at 48 weeks (AI424-007): A dose-ranging, safety, and efficacy comparative trial of atazanavir at three doses in combination with didanosine and stavudine in antiretroviral-naive subjects
    • for the AI424-007 Clinical Trial Group
    • Sanne I, Piliero P, Squires K, Thiry A, Schnittman S, for the AI424-007 Clinical Trial Group. Results of a phase 2 clinical trial at 48 weeks (AI424-007): a dose-ranging, safety, and efficacy comparative trial of atazanavir at three doses in combination with didanosine and stavudine in antiretroviral-naive subjects. J Acquir Immune Defic Syndr 2003;32:18-29.
    • (2003) J. Acquir. Immune Defic. Syndr. , vol.32 , pp. 18-29
    • Sanne, I.1    Piliero, P.2    Squires, K.3    Thiry, A.4    Schnittman, S.5
  • 48
    • 0037661234 scopus 로고    scopus 로고
    • Therapy with atazanavir plus saquinavir in patients failing highly active antiretroviral therapy: A randomized comparative pilot trial
    • Haas D, Zala C, Schrader S, et al. Therapy with atazanavir plus saquinavir in patients failing highly active antiretroviral therapy: a randomized comparative pilot trial. AIDS 2003;17:1339-49.
    • (2003) AIDS , vol.17 , pp. 1339-1349
    • Haas, D.1    Zala, C.2    Schrader, S.3
  • 49
    • 1642465026 scopus 로고    scopus 로고
    • Dose-ranging, randomized, clinical trial of atazanavir with lamivudine and stavudine in antiretroviral-naive subjects: 48-week results
    • Murphy R, Sanne I, Cahn P, et al. Dose-ranging, randomized, clinical trial of atazanavir with lamivudine and stavudine in antiretroviral-naive subjects: 48-week results. AIDS 2003;17:2603-14.
    • (2003) AIDS , vol.17 , pp. 2603-2614
    • Murphy, R.1    Sanne, I.2    Cahn, P.3
  • 50
    • 13644258142 scopus 로고    scopus 로고
    • The LOPSAQ study: 24-week analysis of the double protease inhibitor (PI) salvage regimen containing lopinavir (LPV/r) plus saquinavir (SQV) without any additional antiretroviral (ART) therapy
    • [abstract 583]
    • Staszewski S, Dauer B, Von Hentig N, et al. The LOPSAQ study: 24-week analysis of the double protease inhibitor (PI) salvage regimen containing lopinavir (LPV/r) plus saquinavir (SQV) without any additional antiretroviral (ART) therapy. Antivir Ther 2003;8 Suppl 1 :342[abstract 583].
    • (2003) Antivir. Ther. , vol.8 , Issue.SUPPL. 1 , pp. 342
    • Staszewski, S.1    Dauer, B.2    Von Hentig, N.3
  • 51
    • 13644257341 scopus 로고    scopus 로고
    • Salvage therapy with lopinavir/ritonavir (LPV/R), amprenavir (APV) ± an additional boost with ritonavir (RTV): 1-year results of puzzle 1-ANRS104 study
    • and the Puzzle 1 Group. [abstract 585]
    • Raguin G, Chene G, Morand-Joubert L, and the Puzzle 1 Group. Salvage therapy with lopinavir/ritonavir (LPV/R), amprenavir (APV) ± an additional boost with ritonavir (RTV): 1-year results of puzzle 1-ANRS104 study. Antivir Ther 2003;8 Suppl 1:343[abstract 585].
    • (2003) Antivir. Ther. , vol.8 , Issue.SUPPL. 1 , pp. 343
    • Raguin, G.1    Chene, G.2    Morand-Joubert, L.3
  • 52
    • 13644258749 scopus 로고    scopus 로고
    • A pilot study of saquinavir-SGC (SQV) and lopinavir/ritonavir (LPV/R) twice daily in protease inhibitor (PI) naive HIV+ individuals: Protease inhibitor concentrations and week 24 results
    • [abstract 571]
    • Hellinger J, Cohen C, Morris A, et al. A pilot study of saquinavir-SGC (SQV) and lopinavir/ritonavir (LPV/R) twice daily in protease inhibitor (PI) naive HIV+ individuals: protease inhibitor concentrations and week 24 results. Antivir Ther 2003;8 Suppl 1:339[abstract 571].
    • (2003) Antivir. Ther. , vol.8 , Issue.SUPPL. 1 , pp. 339
    • Hellinger, J.1    Cohen, C.2    Morris, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.