Membrane-anchored β2-microglobulin stabilizes a highly receptive state of MHC class I molecules

Journal of Immunology

Volumn 174, Issue 4, 2005, Pages 2116-2123

  Berko, Dikla ^a,b   Carmi, Yaron ^a   Cafri, Gal ^a   Ben Zaken, Shimrit ^a,c   Sheikhet, Helena Migalovich ^d   Tzehoval, Esther ^d   Eisenbach, Lea ^d   Margalit, Alon ^a,c   Gross, Gideon ^a,c  

^a MIGAL GALILEE TECHNOLOGY CENTER   (Israel)

^b TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^c TEL HAI COLLEGE   (Israel)

^d WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 2 MICROGLOBULIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DIMERIZATION; GENETIC TRANSFECTION; GROWTH INHIBITION; IMMUNOPRECIPITATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MEMBRANE BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; THERMOSTABILITY; TUMOR GROWTH;

EID: 13544277678     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.174.4.2116     Document Type: Article

References (39)

1. 2-microglobulin in the intracellular transport and surface expression of murine class I histocompatibility molecules. J. Immunol. 142:2796.
2. 2- Microglobulin induces a conformational change in an MHC class I H chain that occurs intracellularly and is maintained at the cell surface. J. Immunol. 153:3533.
3. Cresswell, P., N. Bangia, T. Dick, and G. Diedrich. 1999. The nature of the MHC class I peptide loading complex. Immunol. Rev. 172:21.
4. Williams, A., C. A. Peh, and T. Elliott. 2002. The cell biology of MHC class I antigen presentation. Tissue Antigens 59:3.
5. Gakamsky, D. M., P. J. Bjorkman, and I. Pecht. 1996. Peptide interaction with a class I major histocompatibility complex-encoded molecule: allosteric control of the ternary complex stability. Biochemistry 35:14841.
6. b complex. Biochemistry 38:12165.
7. Gakamsky, D. M., D. M. Davis, J. L. Strominger, and I. Pecht. 2000. Assembly and dissociation of human leukocyte antigen (HLA)-A2 studied by real-time fluorescence resonance energy transfer. Biochemistry 39:11163.
8. 2-microglobulin dissociation rate is an accurate measure of the stability of MHC class I heterotrimers and depends on which peptide is bound. J. Immunol. 149:1896.
9. b molecules are noncooperative. J. Immunol. 157:2256.
10. Matko, J., Y. Bushkin, T. Wei, and M. Edidin. 1994. Clustering of class I HLA molecules on the surfaces of activated and transformed human cells. J. Immunol. 152:3353.
11. Machold, R. P., and H. L. Ploegh. 1996. Intermediates in the assembly and degradation of class I major histocompatibility complex (MHC) molecules probed with free heavy chain-specific monoclonal antibodies. J. Exp. Med. 184:2251.
12. 2-microglobulin in peptide binding by class 1 molecules. Science 250:1423.
13. b class I major histocompatibility complex binding of exogenous peptides. Proc. Natl. Acad. Sci. USA 87:7517.
14. b class I major histocompatibility complex binding of an exogenous influenza peptide. Proc. Natl. Acad. Sci. USA 88:301.
15. 2-microglobulin promoting functional peptide association with purified soluble class I MHC molecules. Nature 349:74.
16. 2-microglobulin is required for antigenic peptide binding to isolated class I major histocompatibility complex molecules. Eur. J. Immunol. 21:2289.
17. 2-microglobulin regulation of cell surface MHC class I conformation and expression. J. Immunol. 148:3723.
18. 2-microglobulin domain. Eur. J. Immunol. 24:2633.
19. Mettez, E., P. Langlade-Demoyen, H. Gournier, F. Martinen, J. Maryanski, P. Kourilsky, and J. P. Abastado. 1995. Cells expressing a major histocompatibility complex class I molecule with a single covalently bound peptide are highly immunogenic. J. Exp. Med. 181:493.
20. Toshitani, K., V. Braud, M. J. Browning, N. Murray, A. J. McMichael, and W. F. Bodmer. 1996. Expression of a single-chain HLA class I molecule in a human cell line: presentation of exogenous peptide and processed antigen to cytotoxic T lymphocytes. Proc. Natl. Acad. Sci. USA 93:236.
21. Lone, Y. C., I. Motta, E. Mottez, Y. Guilloux, A. Lim, F. Demay, J. P. Levraud, P. Kourilsky, and J. P. Abastado. 1998. In vitro induction of specific cytotoxic T lymphocytes using recombinant single-chain MHC class I/peptide complexes. J. Immunother. 21:283.
22. d interact with NK and TCR. J. Immunol. 163:3699.
23. 2-microglobulin constructs. J. Immunol. 160:1598.
24. 2-microglobulin enhances the MHC stability and antigenicity of suboptimal CTL epitopes. J. Immunol. 162:6024.
25. 2-microglobulin covalently linked peptides: specific binding to a T cell hybridoma. J. Immunol. 162:2671.
26. 2m fusion molecules. Eur. J. Immunol. 31:440.
27. Yu, Y. Y., N. Netuschil, L. Lybarger, J. M. Connolly, and T. H. Hansen. 2002. Cutting edge: single-chain trimers of MHC class I molecules form stable structures that potently stimulate antigen-specific T cells and B cells. J. Immunol. 168:3145.
28. Lybarger, L., Y. Y. Yu, M. J. Miley, D. H. Fremont, N. Myers, T. Primeau, S. M. Truscott, J. M. Connolly, and T. H. Hansen. 2003. Enhanced immune presentation of a single-chain major histocompatibility complex class I molecule engineered to optimize linkage of a C-terminally extended peptide. J. Biol. Chem. 278:27105.
29. + T cells. Int. Immunol. 15:1379.
30. Ljunggren, H. G., and K. Karre. 1985. Host resistance directed selectively against H-2-deficient lymphoma variants: analysis of the mechanism. J. Exp. Med. 162:1745.
31. Karttunen, J., S. Sanderson, and N. Shastri. 1992. Detection of rare antigen-presenting cells by the lacZ T-cell activation assay suggests an expression cloning strategy for T-cell antigens. Proc. Natl. Acad. Sci. USA 89:6020.
32. Porgador, A., J. W. Yewdell, Y. Deng, J. R. Bennink, and R. N. Germain. 1997. Localization, quantitation, and in situ detection of specific peptide-MHC class I complexes using a monoclonal antibody. Immunity 6:715.
33. 2-microglobulin: interactions with murine MHC I molecules. Mol. Immunol. 35:919.
34. 2-microglobulin and associated MHC and differentiation antigens. Immunogenetics 13:483.
35. 2m. Eur. J. Immunol. 25:1609.
36. 2-microglobulin on major histocompatibility complex I peptide loading and the engineering of a high affinity variant: implications for peptide-based vaccines. J. Biol. Chem. 273:28010.
37. Ortiz-Navarrete, V., and G. J. Hammerling. 1991. Surface appearance and instability of empty H-2 class I molecules under physiological conditions. Proc. Natl. Acad. Sci. USA 88:3594.
38. Townsend, A., T. Elliott, V. Cerundolo, L. Foster, B. Barber, and A. Tse. 1990. Assembly of MHC class I molecules analyzed in vitro. Cell 62:285.
39. Elliott, T., V. Cerundolo, J. Elvin, and A. Townsend. 1991. Peptide-induced conformational change of the class I heavy chain. Nature 351:402.