Evolution of enzymatic activities in the orotidine 5′-monophosphate decarboxylase suprafamily: Enhancing the promiscuous D-arabino-hex-3-ulose 6-phosphate synthase reaction catalyzed by 3-keto-l-gulonate 6-phosphate decarboxylase

Biochemistry

Volumn 44, Issue 6, 2005, Pages 1807-1815

  Yew, Wen Shan ^a   Akana, Julie ^a   Wise, Eric L ^b   Rayment, Ivan ^b   Gerlt, John A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; BACTERIA; CATALYSIS; CHEMICAL ANALYSIS; CONDENSATION; ESCHERICHIA COLI; ORGANIC COMPOUNDS;

ACTIVE SITE RESIDUES; ALDOL CONDENSATION; DECARBOXYLATION REACTION; METHYLOTROPHIC BACTERIA;

ENZYMES;

3 KETO LEVO GULONATE 6 PHOSPHATE DECARBOXYLASE; ASCORBIC ACID; DEXTRO ARABINOHEX 3 ULOSE 6 PHOSPHATE SYNTHASE; FORMALDEHYDE; MAGNESIUM; OROTIDINE 5' PHOSPHATE DECARBOXYLASE; UNCLASSIFIED DRUG;

ALDOL REACTION; ARTICLE; CATABOLISM; CATALYSIS; CATALYST; DECARBOXYLATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; ESCHERICHIA COLI; METHYLOMONAS; METHYLOTROPHIC BACTERIUM; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ALIGNMENT;

ALANINE; ALDEHYDE-LYASES; ALDEHYDES; AMINO ACID SUBSTITUTION; ARGININE; ASPARTIC ACID; CARBOXY-LYASES; CATALYSIS; DECARBOXYLATION; ENZYME STABILITY; ESCHERICHIA COLI PROTEINS; EVOLUTION, MOLECULAR; FORMALDEHYDE; GLUTAMIC ACID; HISTIDINE; KETOSES; METHYLOMONAS; OROTIDINE-5'-PHOSPHATE DECARBOXYLASE; RIBULOSEPHOSPHATES; STEREOISOMERISM; THREONINE; VALINE;

ESCHERICHIA; ESCHERICHIA COLI K12; METHYLOMONAS AMINOFACIENS; TAXUS;

EID: 13544277381     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi047815v     Document Type: Article

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