Regional dispersion of L-type calcium current in ventricular myocytes of German shepherd dogs with lethal cardiac arrhythmias

Heart Rhythm

Volumn 2, Issue 2, 2005, Pages 172-176

  Protas, Lev ^a   Sosunov, Eugene A ^a   Anyukhovsky, Evgeny P ^a   Moïse, N Sydney ^b   Rosen, Michael R ^a   Robinson, Richard B ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b Department of Obstetrics Gynecology   (United States)

Author keywords

Arrhythmia; Calcium current; Catecholamines; Electrophysiology; Ion channels; Sudden death

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM ION; ISOPRENALINE;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; DENSITY; DISPERSION; DOG; HEART ARRHYTHMIA; HEART LEFT VENTRICLE; HEART MUSCLE CELL; HEART VENTRICLE SEPTUM; LETHALITY; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; SUDDEN DEATH; T WAVE;

ACTION POTENTIALS; ANIMALS; ARRHYTHMIA; CALCIUM CHANNELS; DEATH, SUDDEN, CARDIAC; DISEASE MODELS, ANIMAL; DOGS; HEART VENTRICLES; MYOCYTES, CARDIAC;

EID: 13544276464     PISSN: 15475271     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.hrthm.2004.10.041     Document Type: Article

References (14)

1. R.F. Gilmour Jr N.S. Moise Triggered activity as a mechanism for inherited ventricular arrhythmias in German shepherd dogs J Am Coll Cardiol 27 1996 1526-1533
2. N.S. Moise V. Meyers-Wallen W.J. Flahive A. Valentine J.M. Scarlett C.A. Brown M.J. Chavkin D.A. Dugger S. Renaud-Farrell B. Kornreich W.C. Schoenborn R. Sparks R.F. Gilmour Jr. Inherited ventricular arrhythmias and sudden death in German shepherd dogs J Am Coll Cardiol 24 1994 233-243
3. N.S. Moise R.F. Gilmour Jr M.L. Riccio An animal model of spontaneous arrhythmic death J Cardiovasc Electrophysiol 8 1997 98-103
4. E.A. Sosunov E.P. Anyukhovsky A. Shvilkin M. Hara S.F. Steinberg P. Danilo Jr M.R. Rosen N.S. Moise J. Merot V. Probst F. Charpentier Y. Legeay H. Le Marec Abnormal cardiac repolarization and impulse initiation in German shepherd dogs with inherited ventricular arrhythmias and sudden death Cardiovasc Res 42 1999 65-79
5. M.W. Dae R.J. Lee P.C. Ursell M.C. Chin C.A. Stillson N.S. Moise Heterogeneous sympathetic innervation in German shepherd dogs with inherited ventricular arrhythmia and sudden cardiac death Circulation 96 1997 1337-1342
6. J. Qu R.B. Robinson Cardiac ion channel expression and regulation: The role of innervation J Mol Cell Cardiol 37 2004 439-448
7. L.C. Freeman L.M. Pacioretty N.S. Moise R.S. Kass R.F.J. Gilmour Jr Decreased density of Ito in left ventricular myocytes from German shepherd dogs with inherited arrhythmias J Cardiovasc Electrophysiol 8 1997 872-883
8. M.N. Obreztchikova E.A. Sosunov E.P. Anyukhovsky N.S. Moise R.B. Robinson M.R. Rosen Heterogeneous ventricular repolarization provides a substrate for arrhythmias in a German shepherd model of spontaneous arrhythmic death Circulation 108 2003 1389-1394
9. N.S. Moise P.F. Moon W.J. Flahive D. Brittain H.P. Pride B.A. Lewis D.P. Zipes R.J. Lee R.F. Gilmour Jr Phenylephrine-induced ventricular arrhythmias in dogs with inherited sudden death J Cardiovasc Electrophysiol 7 1996 217-230
10. A.L. Wit M.R. Rosen Afterdepolarizations and triggered activity: distinction from automaticity as an arrhythmogenic mechanism In: H.A. Fozzard E. Haber R.B. Jennings A.M. Katz H.E. Morgan The Heart and Cardiovascular System 1991 Raven Press New York 2113-2163
11. i cycling in the German Shepherd sudden death model Am J Physiol 282 2002 H1181-H1188
12. B.F. Hoffman S.D. Guo S.J. Feinmark Arrhythmias caused by platelet activating factor J Cardiovasc Electrophysiol 7 1996 120-133
13. Ca,L via ventricular Y2 receptors Am J Physiol 277 1999 H940-H946
14. Ca.L Circ Res 93 2003 972-979