Experimental therapeutic intervention with ascorbic acid in ethanol induced testicular injuries in rats

Indian Journal of Experimental Biology

Volumn 43, Issue 2, 2005, Pages 172-176

  Maneesh, M ^a   Jayalakshmi, H ^a   Dutta, Sanjiba ^a   Chakrabarti, Amit ^a   Vasudevan, D M ^b  

^a SIKKIM MANIPAL INSTITUTE OF MEDICAL SCIENCES   (India)

^b AMRITA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Ascorbic acid; Ethanol; Oxidative stress; Steroids; Testes

Indexed keywords

ALCOHOL; ANTIOXIDANT; ASCORBIC ACID; GLUTATHIONE; LIPID PEROXIDE; SEX HORMONE;

ANIMAL; ARTICLE; BIOSYNTHESIS; BODY WEIGHT; DRUG EFFECT; ENZYMOLOGY; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; OXIDATIVE STRESS; RAT; TESTIS;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; BODY WEIGHT; ETHANOL; GLUTATHIONE; GONADAL STEROID HORMONES; LIPID PEROXIDES; MALE; OXIDATIVE STRESS; RATS; TESTIS;

EID: 13544267640     PISSN: 00195189     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. rd .edition (Cambridge Univ Press, Cambridge) 1992.
2. Sigman M, Lipshultz L & Howards S, Infertility in the male, edited by L A Lipshultz and S S Howards (Chuchill Livingstone, New York) 1991.
3. Adler R A, Clinically important effects of alcohol on endocrine function, Alcoholism: Clin Exp Res, 74 (1992) 957.
4. Rosenblum F R, Gavaler J S & Van Theil D H, Vitamin A at pharmacologic doses ameliorates the membrane lipid peroxidation injury and testicular atrophy that occurs with chronic alcohol feeding in rats, Alcohol Alcohol, 2 (1987) 241.
5. Rommerts F F G, Testosterone: an overview of biosynthesis transport metabolism and action in Testosterone action deficiency substitution, edited by E Nieschlag and H M Hehre, (Springler-Verlag, Berlin, Heidelberg, New York) 1990, 1.
6. Mari M, Wu D, Nieto N & Cederbaum A I, CYP2EI-dependent toxicity and up regulation of antioxidant genes, J Biomed Sci, 8 (2001) 52.
7. Kumar G P, Seerwani N, Laloraya M, Nivasarkar M, Verma S & Singh A, Superoxide dismutase as a regulatory switch in mammalian testes, Biochem Biophys Res Commun, 173 (1990) 302.
8. Fernandez-Checha J C, Gracia-Ruitz C, Ootkens M & Kaplowitz N, Impaired uptake of glutathione by hepatic mitochondria from chronic ethanol-fed rats; tracer kinetic studies in vitro and in vivo and susceptibility to oxidative stress, J Clin Invest, 87 (1991) 397.
9. Buettner G R, The pecking order of free radicals and antioxidants: lipids peroxidation, alpha-tocopherol and ascorbate, Arch Biochem Biophys, 300 (1993) 535.
10. Maxwell S R, Can antioxidants prevent ischaemic heart disease? J Clin Pharm Ther, 18 (1993) 85.
11. Sinnhuber R O, Yu T C & Yu T C, Characterization of the red pigment formed in the thiobarbituric acid determination of oxidative capacity, Food Res, 23 (1958) 626.
12. Lowry O H, Rosebrough N J, Farr A L & Randall R J, Protein measurement with folin phenol reagent, J Biol Chem, 193 (1951) 265.
13. Roe J H & Kuther C A, The determination of ascorbic acid in whole blood and urine through the 2, 4-dinitrophenyl hydrazine derivative of dehydroascorbic acid, J Biol Chem 147 (1943) 399.
14. Ellman G, The sulphydryl groups, Arch Biochem Biophys, 32 (1959) 70.
15. Mahley A C & Chance B, in Methods in biochemical analysis, edited by D. Glick, (Wiley Inter Science, New York) 1954, 357.
16. Marklund S & Marklund G, Involvement of superoxide radical in the autoxidation pyrogallol and a convenient assay for superoxide dismutase, Eur J Biochem, 7 (1974) 469.
17. Paliga D E & Valentine W N, Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase, J Lab Clin Med, 70 (1967) 1158.
18. rd edn. (Academic Press, Inc. Florida) 1983, 258.
19. Habig W H, Pabst M J & Jakoby W B, Glutathione S-transferase, the first enzyme step in mereapturic acid formation, J Biol Chem, 249 (1974) 7130.
20. Talalay P, Hydroxysteroid dehydrogenase, in Methods in ezymology, edited by S P Colowick and N O Kaplan (Academic Press, New York) 1962, 512.
21. Jarbak J, Soluble 17 β-hydroxy steroid dehydrogenase of human placenta, in Methods in enzymology, edited by S P Colowick and N O Kaplan (Academic Press, New York) 1969, 746.
22. Dabrowski K & Ciereszko A, Ascorbic acid protects against male infertility in a teleost fish, Experimentia, 52 (1996) 97.
23. McCall M R & Balz F, Can antioxidant vitamins materially reduce oxidative damage in humans? Free Rad Biol Med, 26 (1999) 1034.
24. Ujjal Baran Das, Mousumi Mallick, Jogendra Mohan Debnath & Debidas Ghosh, Protective effect of ascorbic acid on cyclophosphamide-induced testicular gametogenic and androgenic disorders in male rats, Asian J Androl, 4 (2002) 201.
25. Debnath D & Mandal T K, Study of quinalphos (an environmental oestrogenic insecticide) formulation (Ekalux 25 E.C) induced damage of the testicular tissues and antioxidant defense systems in Sprague-Dawley albino rats, J Appl Toxicol, 20 (2000) 197.
26. Chainy G B N, Samantaray S & Samanta L, Testosterone-induced changes in testicular antioxidant system, Audrologia, 29 (1997) 343.
27. Trasler J M, Hales B F & Robaire B, Chronic low dose cyclophosphamide treatment of adult male rats: effect on fertility, pregnancy outcome and progeny, Biol Reprod 34 (1986) 275.
28. Ghosh D, Das U B, Ghosh S, Mallick M & Dehnath J, Testicular gametogenic and steroidogenic activities in cyclophosphamide treated rat: A correlative study with testicular oxidative stress, Drug Chem Toxicol, 25 (2002) 281.
29. Biswas N M, Chaudhuri A, Sarkar M & Biswas R, Effect of ascorbic acid on in vitro synthesis of testosterone in rat testis, Indian J Exp Biol, 34 (1996) 612.
30. Huang H F S, Marshall G R, Rosenberg R A & Nieschalg E, Restoration of spermatogenesis by high levels of testosterone in hypophysectomized rats after long-term regression, Acta Endocrinol, 16 (1987) 433.
31. Melin A M, Peuchant E, Perromat A & Clerc M, In vitro influence of ascorbate on lipid peroxidation in rat testis and heart microsomes, Mol Cell Biochem, 169 (1997) 171.
32. Ishihara M, Itoh M, Miyamoto K, Suna S, Takeuchi Y & Takenaka I, Spermatogenic disturbance induced by di-(2-ethylhexyl) phthalate is significantly prevented by treatment with antioxidant vitamins in the rat, Int J Androl, 23 (2000) 85.