Olig2 expression, GFAP, p53 and 1p loss analysis contribute to glioma subclassification

Neuropathology and Applied Neurobiology

Volumn 31, Issue 1, 2005, Pages 62-69

  Mokhtari, K ^a,b   Paris, S ^b   Aguirre Cruz, L ^b,c   Privat, N ^a   Criniere E ^b   Marie, Y ^b   Hauw, J J ^a   Kujas, M ^a,b   Rowitch, D ^d   Hoang Xuan, K ^a,b   Delattre, J Y ^a,b   Sanson, Marc ^a,b  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b INSERM   (France)

^c U de Invest del Sistema Nervioso   (Mexico)

^d DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Chromosome 1p; GFAP; Glioma; Olig2; Oligodendroglioma; p53

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; HELIX LOOP HELIX PROTEIN; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; PROTEIN; PROTEIN P53; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; ASTROCYTOMA; CANCER CLASSIFICATION; CANCER GRADING; CANCER SURVIVAL; CELL SUBPOPULATION; CHROMOSOME 1P; CHROMOSOME LOSS; CONTROLLED STUDY; GLIOBLASTOMA; GLIOBLASTOMA WITH OLIGODENDROGLIAL COMPONENT; GLIOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MIXED TUMOR; OLIGODENDROGLIA; OLIGODENDROGLIOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BRAIN NEOPLASMS; CHROMOSOMES, HUMAN, PAIR 1; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOMA; HUMANS; IMMUNOHISTOCHEMISTRY; LOSS OF HETEROZYGOSITY; NERVE TISSUE PROTEINS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 13544261400     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2990.2004.00612.x     Document Type: Article

References (22)

1. Kleihues P, Louis DN, Scheithauer BW, Rorke LB, Reifenberger G, Burger PC, Cavenee WK. The WHO classification of tumors of the nervous system. J Neuropathol Exp Neurol 2002; 61: 215-25
2. Cairncross G, Macdonald D, Ludwin S, Lee D, Cascino T, Buckner J, Fulton D, Dropcho E, Stewart D, Schold C. Chemotherapy for anaplastic oligodendroglioma. National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 1994; 12: 2013-21
3. Coons SW, Johnson PC, Scheithauer BW, Yates AJ. Pearl DK. Improving diagnostic accuracy and interobserver concordance in the classification and grading of primary gliomas. Cancer 1997; 79: 1381-93
4. Cairncross Ueki K, Zlatescu MC, Lisle DK, Finkelstein DM, Hammond RR, Silver JS, Stark PC, Macdonald DR, Ino Y, Ramsay DA, Louis DN. Specific genetic predictors of chemotherapeutic and survival in patients with anaplastic oligodendrogliomas. J Natl Cancer Inst 1998; 90: 1473-9
5. Hoang-Xuan K, He J, Huguet S, Mokhtari K, Marie Y, Kujas M, Leuraud P, Delattre JY, Broët P, Poirier J, Sanson M. Molecular heterogeneity of oligodendrogliomas suggest alternative pathways in tumoral progression. Neurology 2001; 57; 1278-81
6. Bigner SH, Matthews MR, Rasheed BK, Wiltshire RN, Friedman HS, Friedman AH, Stenzel TT, Dawes DM, McLendon RE, Bigner DD, Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization. Am J Pathol 1999; 155: 375-86
7. Ino Y, Betensky RA, Zlatescu MC, Sasaki H, Macdonald DR, Stemmer-Rachamimov AO, Ramsay DA. Cairncross JG, Louis DN. Molecular subtypes of anaplastic oligodendroglioma: implications for patient management at diagnosis. Clin Cancer Res 2001; 7: 839-45
8. Ueki K, Nishikawa R, Nakazato Y, Hirose T, Hirato J, Funada N, Fujimaki T, Hojo S, Kubo O, Ide T, Usui M, Ochiai C, Ito S, Takahashi H, Mukasa A, Asai A, Kirino T. Correlation of histology and molecular genetic analysis of 1p, 19q, 10q, TP53, EGFR, CDK4, and CDKN2A in 91 astrocytic and oligodendroglial tumors. Clin Cancer Res 2002; 8: 196-201
9. Lu QR, Park JK, Noll E, Chan JA, Alberta J, Yuk D, Alzamora MG, Louis DN, Stiles CD, Rowitch DH, Black PM. Oligodendrocyte lineage genes (OLIG) as molecular markers for human glial brain tumors. Proc Natl Acad Sci USA 2001; 98: 10851-6
10. Marie Y, Sanson M, Mokhtari K, Leuraud P, Kujas M, Delattre JY, Poirier J, Zalc B, Hoang-Xuan K. OLIG2 as a specific marker of oligodendroglial tumour cells. Lancet 2001;358:298-300
11. Aguirre-Cruz L, Mokhtari K, Hoang-Xuan K, Marie Y, Crinière E, Taillibert S, Lopes M, Delattre JY, Sanson M. Analysis of the bHLH transcription factors Olig1 and Olig2 in brain tumors. J Neuro-Oncol 2004; 67: 265-71
12. Bouvier C, Bartoli C, Aguirre-Cruz L, Virard I, Colin C, Fernandez C, Gouvernet J, Figarella-Branger D. Shared oligodendrocyte lineage gene expression in gliomas and oligodendrocyte progenitor cells. J Neurosurg 2003; 99: 344-50
13. He J, Mokhtari K, Sanson M, Marie Y, Kujas M, Muguet S, Leuraud P, Capelle L, Delattre JY, Poirier J, Hoang-Xuan K. Glioblastomas with an oligodendroglial component: a pathological and molecular study. J Neuropath Exp Neurol 2001;60:863-71
14. Ligon KL, Alberta JA, Kho AT, Weiss J, Kwaan MR, Nutt CL, Louis DN, Stiles CD, Rowitch DH. The oligodendroglial lineage marker OLIG2 is universally expressed in diffuse gliomas. J Neuropath Exp Neurol 2004, 499-509.
15. Riemenschneider MJ, Koy TH, Reifenberger G. Expression of oligodendrocyte lineage genes in oligodendroglial and astrocytic gliomas. Acta Neuropathol (Berl) 2004; 107: 277-82
16. Ohnishi A, Sawa H, Tsuda M, Sawamura Y, Itoh T, Iwasaki Y, Nagashima K. Expression of the oligodendroglial lineage-associated markers Olig1 and Olig2 in different types of human gliomas. J Neuropathol Exp Neurol 2003; 62: 1052-9
17. Shoshan Y, Nishiyama A, Chang A, Mork S, Barnett GH, Cowell JK, Trapp BD, Staugaitis SM. Expression of oligodendrocyte progenitor cell antigens by gliomas: implications for the histogenesis of brain tumors. Proc Natl Acad Sci USA 1999; 96: 10361-6
18. Daumas-Duport C, Varlet P, Tucker ML, Beuvon F, Cervera P, Chodkiewicz JP. Oligodendrogliomas. Part I. Patterns of growth, histological diagnosis, clinical and imaging correlations: a study of 153 cases. J Neurooncol 1997; 34: 37-59
19. Reis RM, Kara A, Kleihues P, Ohgaki H. Genetic evidence of the neoplastic nature of gemistocytes in astrocytomas. Acta Neuropathol (Berl) 2001; 102: 422-5
20. Kraus JA, Koopmann J, Kaskel P, Maintz D, Brandner S, Schramm J, Louis DN, Wiestler OD, von Deimling A. Shared allelic losses on chromosomes 1p and 19q suggest a common origin of oligodendroglioma and oligoastrocytoma. J Neuropathol Exp Neurol 1995; 54: 91-5
21. Dong ZQ, Pang JC, Tong CY, Zhou LF, Ng HK. Clonality of oligoastrocytomas. Hum Pathol 2002; 33: 528-35
22. Azzarelli B, Miravalle L, Vidai R. Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors. J Neuropathol Exp Neurol 2004; 63: 170-9