Application of high-dose propofol during ischemia improves postischemic function of rat hearts: Effects on tissue antioxidant capacity

Canadian Journal of Physiology and Pharmacology

Volumn 82, Issue 10, 2004, Pages 919-926

  Xia, Zhengyuan ^a   Godin, David V ^a   Ansley, David M ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Heart; Ischemia; Oxidative stress; Propofol; Rat

Indexed keywords

PROPOFOL; REACTIVE OXYGEN METABOLITE;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; CARDIOPULMONARY BYPASS; CONFERENCE PAPER; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG MEGADOSE; DRUG RESPONSE; HEART CONTRACTION; HEART FUNCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART SURGERY; ISOLATED HEART; LIPID PEROXIDATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIOXIDANTS; HEART; MALE; MYOCARDIAL ISCHEMIA; MYOCARDIUM; PROPOFOL; RATS; RATS, SPRAGUE-DAWLEY;

EID: 13544258769     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y04-097     Document Type: Conference Paper

References (41)

1. Ambrosio, G., and Tritto, I. 1999. Reperfusion injury: experimental evidence and clinical implications. Am. Heart J. 138: S69-S75.
2. Ansley, D.M., Sun, J., Visser, W.A., Dolman, J., Godin, D.V., Garnett, M.E., and Qayumi, A.K. 1999. High dose propofol enhances red cell antioxidant capacity during CPB in humans. Can. J. Anaesth. 46: 641-648.
3. 2a- isoprostane formation in high risk patients during ACBP surgery. Can. J. Anaesth. 49(Suppl. 1): 43A.
4. 2t-isoprostane concentration and early postoperative cardiac depression following warm heart surgery. J. Thorac. Cardiovasc. Surg. 126: 1222-1223.
5. Bell, D., Jackson, M., Nicoll, J.J., Millar, A., Dawes, J., and Muir, A.L. 1990. Inflammatory response, neutrophil activation, and free radical production after acute myocardial infarction: effect of thrombolytic treatment. Br. Heart J. 63: 82-87.
6. Breisblatt, W.M., Stein, K.L., Wolfe, C.J., Follansbee, W.P., Capozzi, J., Armitage, J.M., and Hardesty, R.L. 1990. Acute myocardial dysfunction and recovery: a common occurrence after coronary bypass surgery. J. Am. Coll. Cardiol. 15: 1261-1269.
7. Bryson, H.M., Fulton, B.R., and Faulds, D. 1995. Propofol. An update of its use in anaesthesia and conscious sedation. Drugs, 50: 513-559.
8. Buffon, A., Santini, S.A., Ramazzotti, V., Rigattieri, S., Liuzzo, G., Biasucci, L.M., Crea, F., Giardina, B., and Maseri, A. 2000. Large, sustained cardiac lipid peroxidation and reduced antioxidant capacity in the coronary circulation after brief episodes of myocardial ischemia. J. Am. Coll. Cardiol. 35: 633-639.
9. Chiabrando, C., Avanzini, F., Rivalta, C., Colombo, F., Fanelli, R., Palumbo, G., and Roncaglioni, M. 2002. Long-term vitamin E supplementation fails to reduce lipid peroxidation in people at cardiovascular risk: analysis of underlying factors. Curr. Control Trials Cardiovasc. Med. 3: 5.
10. Clermont, G., Vergely, C., Jazayeri, S., Lahet, J.J., Goudeau, J.J., Lecour, S. et al. 2002. Systemic free radical activation is a major event involved in myocardial oxidative stress related to cardiopulmonary bypass. Anesthesiology, 96: 80-87.
11. De Hert, S.G., ten Broecke, P.W., Mertens, E., Van Sommeren, E.W., De Blier, I.G., Stockman, B.A., and Rodrigus, I.E. 2002. Sevoflurane but not propofol preserves myocardial function in coronary surgery patients. Anesthesiology, 97: 42-49.
12. De Hert, S.G., Cromheecke, S., ten Broecke, P.W., Mertens, E., De Blier, I.G., Stockman, B.A. et al. 2003. Effects of propofol, desflurane, and sevoflurane on recovery of myocardial function after coronary surgery in elderly high-risk patients. Anesthesiology, 99: 314-323.
13. Hamilton, D.L., Boyett, M.R., Harrison, S.M., Davies, L.A., and Hopkins, P.M. 2000. The concentration-dependent effects of propofol on rat ventricular myocytes. Anesth. Analg. 91: 276-282.
14. Hardy, J.F., and Belisle, S. 1993. Inotropic support of the heart that fails to successfully wean from cardiopulmonary bypass: the Montreal Heart Institute experience. J. Cardiothorac. Vasc. Anesth. 7(4, Suppl. 2): 33-39.
15. Iuliano, L., Pratico, D., Greco, C., Mangieri, E., Scibilia, G., Fitz-Gerald, G.A., and Violi, F. 2001. Angioplasty increases coronary sinus F2-isoprostane formation: evidence for in vivo oxidative stress during PTCA. J. Am. Coll. Cardiol. 37: 76-80.
16. Kevin, L.G., Novalija, E., Riess, M.L., Camara, A.K., Rhodes, S.S., and Stowe, D.F. 2003. Sevoflurane exposure generates superoxide but leads to decreased superoxide during ischemia and reperfusion in isolated hearts. Anesth. Analg. 96: 949-955.
17. Kowaltowski, A.J., Castilho, R.F., and Vercesi, A.E. 2001. Mitochondrial permeability transition and oxidative stress. FEBS Lett. 495: 12-15.
18. Mangano, D.T. 1985. Biventricular function after myocardial revascularization in humans: deterioration and recovery patterns during the first 24 h. Anesthesiology, 62: 571-577.
19. Mathur, S., Farhangkhgoee, P., and Karmazyn, M. 1999. Cardioprotective effects of propofol and sevoflurane in ischemic and reperfused rat hearts: role of K(ATP) channels and interaction with the sodium-hydrogen exchange inhibitor HOE 642 (cariporide). Anesthesiology, 91: 1349-1360.
20. McMurray, J., Chopra, M., Abdullah, I., Smith, W.E., and Dargie, H.J. 1993. Evidence of oxidative stress in chronic heart failure in humans. Eur. Heart J. 14: 1493-1498.
21. Messent, M., Sinclair, D.G., Quinlan, G.J., Mumby, S.E., Gutteridge, J.M., and Evans, T.W. 1997. Pulmonary vascular permeability after cardiopulmonary bypass and its relationship to oxidative stress. Crit. Care Med. 25: 425-429.
22. Morrow, J.D., and Roberts, L.J. 1997. The isoprostanes: unique bioactive products of lipid peroxidation. Prog. Lipid Res. 36: 1-21.
23. Moskowitz, R., and Kukin, M. 1999. Oxidative stress and congestive heart failure. Congest. Heart Failure, 5: 153-163.
24. Murphy, P.G., Myers, D.S., Davies, M.J., Webster, N.R., and Jones, J.G. 1992. The antioxidant potential of propofol (2,6-diisopropylphenol). Br. J. Anaesth. 68: 613-618.
25. Novalija, E., Kevin, L.G., Camara, A.K., Bosnjak, Z.J., Kampine, J.P., and Stowe, D.F. 2003a. Reactive oxygen species precede the epsilon isoform of protein kinase C in the anesthetic preconditioning signaling cascade. Anesthesiology, 99: 421-428.
26. Novalija, E., Kevin, L.G., Eells, J.T., Henry, M.M., and Stowe, D.F. 2003b. Anesthetic preconditioning improves adenosine triphosphate synthesis and reduces reactive oxygen species formation in mitochondria after ischemia by a redox dependent mechanism. Anesthesiology, 98: 1155-1163.
27. Pantos, C., Mourouzis, I., Tzeis, S., Moraitis, P., Malliopoulou, V., Cokkinos, D.D. et al. 2003. Dobutamine administration exacerbates postischaemic myocardial dysfunction in isolated rat hearts: an effect reversed by thyroxine pretreatment. Eur. J. Pharmacol. 460: 155-161.
28. Runzer, T.D., Ansley, D.M., Godin, D.V., and Chambers, G.K. 2002. Tissue antioxidant capacity during anesthesia: propofol enhances in vivo red cell and tissue antioxidant capacity in a rat model. Anesth. Analg. 94: 89-93.
29. Sayin, M.M., Ozatamer, O., Tasoz, R., Kilinc, K., and Unal, N. 2002. Propofol attenuates myocardial lipid peroxidation during coronary artery bypass grafting surgery. Br. J. Anaesth. 89: 242-246.
30. Servin, F., Farinotti, R., Haberer, J.P., and Desmonts, J.M. 1993. Propofol infusion for maintenance of anesthesia in morbidly obese patients receiving nitrous oxide. A clinical and pharmacokinetic study. Anesthesiology, 78: 657-665.
31. Sztark, F., Ichas, F., Ouhabi, R., Dabadie, P., and Mazat, J.P. 1995. Effects of the anaesthetic propofol on the calcium-induced permeability transition of rat heart mitochondria: direct pore inhibition and shift of the gating potential. FEBS Lett. 368: 101-104.
32. Tamaki, F., Oguchi, T., Kashimoto, S., Nonaka, A., and Kumazawa, T. 2001. Effects of propofol on ischemia and reperfusion in the isolated rat heart compared with thiamylal. Jpn. Heart J. 42: 193-206.
33. Toufektsian, M.C., Boucher, F.R., Tanguy, S., Morel, S., and de Leiris, J.G. 2001. Cardiac toxicity of singlet oxygen: implication in reperfusion injury. Antioxid. Redox Signal. 3: 63-69.
34. Ulus, A.T., Aksoyek, A., Ozkan, M., Katircioglu, S.F., and Basu, S. 2003. Cardiopulmonary bypass as a cause of free radical-induced oxidative stress and enhanced blood-borne isoprostanes in humans. Free Radical Biol. Med. 34: 911-917.
35. Wessen, A., Persson, P.M., Nilsson, A., and Hartvig, P. 1993. Concentration-effect relationships of propofol after total intravenous anesthesia. Anesth. Analg. 77: 1000-1007.
36. Westhuyzen, J., Cochrane, A.D., Tesar, P.J., Mau, T., Cross, D.B., Frenneaux, M.P. et al. 1997. Effect of preoperative supplementation with alpha-tocopherol and ascorbic acid on myocardial injury in patients undergoing cardiac operations. J. Thorac. Cardiovasc. Surg. 113: 942-948.
37. Yang, C.Y., Wong, C.S., Yu, C.C., Luk, H.N., and Lin, C.I. 1996. Propofol inhibits cardiac L-type calcium current in guinea pig ventricular myocytes. Anesthesiology, 84: 626-635.
38. 2t-isoprostane formation. Can. J. Physiol. Pharmacol. 81: 14-21.
39. Xia, Z., Godin, D.V., and Ansley, D.M. 2003b. Propofol enhances ischemic tolerance of middle-aged rat hearts: effects on 15-F(2t)-isoprostane formation and tissue antioxidant capacity. Cardiovasc. Res. 59: 113-121.
40. Zaugg, M., Lucchinetti, E., Spahn, D.R., Pasch, T., and Schaub, M.C. 2002. Volatile anesthetics mimic cardiac preconditioning by priming the activation of mitochondrial K(ATP) channels via multiple signaling pathways. Anesthesiology, 97: 4-14.
41. Zorov, D.B., Filburn, C.R., Klotz, L.O., Zweier, J.L., and Sollott, S.J. 2000. Reactive oxygen species (ROS)-induced ROS release: a new phenomenon accompanying induction of the mitochondrial permeability transition in cardiac myocytes. J. Exp. Med. 192: 1001-1014.