4,5-Disubstituted cis-pyrrolidinones as inhibitors of 17β- hydroxysteroid dehydrogenase II. Part 1: Synthetic approach

Tetrahedron Letters

Volumn 46, Issue 9, 2005, Pages 1525-1528

  Cook, James H ^a   Barzya, Jeremy ^a   Brennan, Catherine ^a   Lowe, Derek ^a   Wang, Yamin ^a   Redman, Anikó ^a   Scott, William J ^a   Wood, Jill E ^a  

^a BAYER CORPORATION   (United States)

Author keywords

4,5 Disubstituted pyrrolidinones; Hydroxysteroid dehydrogenase; Intramolecular Michael addition

Indexed keywords

17BETA HYDROXYSTEROID DEHYDROGENASE II; ENZYME INHIBITOR; KETONE DERIVATIVE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CIS ISOMER; DRUG SYNTHESIS; HYDROGENATION; ISOMERIZATION; MICHAEL ADDITION; OSTEOPOROSIS;

EID: 13444310940     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2005.01.003     Document Type: Article

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