Did enzymes evolve to capitalize on quantum tunneling?

Scientist

Volumn 19, Issue 1, 2005, Pages 17-18

  Greener, Mark ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE; DEUTERIUM; ENZYME; HYDROGEN; METHYLMALONYL COENZYME A MUTASE; RHODOPSIN;

ARTICLE; CATALYSIS; CATALYST; CHEMICAL REACTION; ENERGY CONSERVATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; MODEL; MOLECULAR DYNAMICS; PROTON TRANSPORT; QUANTUM MECHANICS; REACTION ANALYSIS; TEMPERATURE DEPENDENCE; TEMPERATURE SENSITIVITY;

EID: 13444304096     PISSN: 08903670     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. S. Tsai, J.P. Klinman, "Probes of hydrogen tunneling with horse liver alcohol dehydrogenase at subzero temperatures," Biochemistry, 40:2303-11, 2001.
2. B.J. Bahnson et al., "A link between protein structure and enzyme-catalyzed hydrogen tunneling," Proc Natl Acad Sci, 94:12797-802, 1997.
3. K.M. Doll et al., "The first experimental test of the hypothesis that enzymes have evolved to enhance hydrogen tunneling," J Am Chem Soc, 125:10877-84, 2003.
4. K.M. Doll et al., "A compelling experimental test of the hypothesis that enzymes have evolved to enhance quantum mechanical tunneling in hydrogen transfer reactions: the beta-neopentylcobalamin system combined with prior adocobalamin data," Inorg Chem, 42:4849-56, 2003.
5. W. Siebrand, Z. Smedarchina, "Temperature dependence of kinetic isotope effects for enzymatic carbon-hydrogen bond cleavage," J Phys Chem B, 108:4185-95, 2004.