Increases in homocysteine are related to worsening of stroop scores in healthy elderly persons: A prospective follow-up study

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 59, Issue 12, 2004, Pages 1323-1327

  Garcia, Angeles ^a   Haron, Yafa ^a   Pulman, Kate ^a   Hua, Lien ^a   Freedman, Morris ^b  

^a QUEEN S UNIVERSITY   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

COBALAMIN; CREATININE; FOLIC ACID; HOMOCYSTEINE;

AGED; ARTICLE; CALIFORNIA VERBAL LEARNING TEST; CEREBROVASCULAR DISEASE; COGNITIVE DEFECT; COHORT ANALYSIS; ELDERLY CARE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MATTIS DEMENTIA RATING SCALE; MINI MENTAL STATE EXAMINATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RATING SCALE; STROOP NEUROPSYCHOLOGICAL INVENTORY;

EID: 13444300914     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/59.12.1323     Document Type: Article

References (24)

1. McCaddon A, Hudson P, Davies G, Hughes A, Williams JH, Wilkinson C. Homocysteine and cognitive decline in healthy elderly. Dement Geriatr Cogn Disord. 2001;12:309-313.
2. Kalmijn S, Launer LJ, Lindemans J, et al. Total homocysteine and cognitive decline in a community-based sample of elderly subjects. The Rotterdam Study. Am J Epidemiol. 1999;150:283-289.
3. Ravaglia G, Forti P, Maioli F, et al. Blood homocysteine and vitamin B levels are not associated with cognitive skills in healthy normally aging subjects. J Nutr Health Aging. 2000;4:218-222.
4. Riggs KM, Spiro A, Tucker K, Rush D. Relations of vitamin B-12, vitamin B-6, folate, and homocysteine to cognitive performance in the normative aging population. Am J Clin Nutr. 1996;63:306-314.
5. Morris MS, Jacques PF, Rosenberg IH, Selhub J. National Health and Nutrition Examination Survey. Hyperhomocysteinemia associated with poor recall in the third National Health and Nutrition Examination Survey. Am J Clin Nutr. 2001;73:927-933.
6. Ravaglia G, Forti PI, Maioli F, et al. Homocysteine and cognitive function in healthy elderly community dwellers in Italy. Am J Clin Nutr. 2003;77:668-673.
7. Duthie SJ, Whalley LJ, Collins AR, Leaper S, Berger K, Deary IJ. Homocysteine, B vitamin status, and cognitive function in the elderly. Am J Clin Nutr. 2002;75:908-913.
8. Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med. 2002;346:476-483.
9. Stewart R, Asonganyi B, Sherwood R. Plasma homocysteine and cognitive impairment in an older British African-Caribbean population. J Am Geriatr Soc. 2002;50:1227-1232.
10. Leblhuber F, Walli J, Widner B, et al. Homocysteine and B vitamins in dementia. Am J Clin Nutr. 2001;73:127-128.
11. Joosten E, Lesaffre E, Riezler R, et al. Is metabolic evidence for vitamin B-12 and folate deficiency more frequent in elderly patients with Alzheimer's disease? J Gerontol Med Sci. 1997;52A:M76-M79.
12. Clarke R, Smith D, Jobst K, et al. Folate, vitamin B-12, and serum total homocysteine levels in confirmed Alzheimer's disease. Arch Neurol. 1998;55:1449-1455.
13. McCaddon A, Davies G, Hudson P, et al. Total serum homocysteine in senile dementia of Alzheimer type. Int J Geriatr Psych. 1998;13:235-239.
14. Lökk J. News and views of folate and elderly persons. J Gerontol Biol Sci Med Sci. 2003;58A:354-361.
15. Stabler SP, Marcell PD, Podell ER, Allen RH, Lindenbaum J. Assay of methylmalonic acid in the serum of patients with cobalamin deficiency using capillary gas chromatography-mass spectrometry. J Clin Invest. 1986;77:1606-1612.
16. Stroop OR. Studies of inference in serial verbal reaction. J Exper Psych. 1935;18:643-662.
17. Mattis S, Dene RS. Dementia Rating Scale. Odessa, FL: Psychological Assessment Resources; 1998.
18. Delis DC, Kramer JH, Kaplan E, Ober BA. California Verbal Learning Test (CAdult Version. San Antonio, TX: Psychological Corporation; 1987.
19. Stuss DT, Levine B. Adult clinical neuropsychology: lessons from studies of the frontal lobes. Annu Rev Psychol. 2002;53:401-433.
20. den Heijer T, Vermeer SE, Clarke R, et al. Homocysteine and brain atrophy on MRI of non-demented elderly. Brain. 2003;126:170-175.
21. West R, Murphy KJ, Armilio ML, Craik FI, Stuss DT. Lapses of intention and performance variability reveal age-related increases in fluctuations of executive control. Brain Cogn. 2002;49:402-419.
22. Chen P, Ratcliff G, Belle SH, Cauley JA, DeKosky ST, Gauguli M. Cognitive tests that best discriminate between presymptomatic AD and those who remain nondemented. Neurology. 2000;55:1847-1853.
23. 6, and vascular disease in AD patients. Neurology. 2002;58:1471-1475.
24. McCaddon A, Regland B, Hudson P, Davis G. Functional vitamin B12 deficiency and Alzheimer disease. Neurology. 2002;58:1395-1399.