Caspase activity inhibition delays programmed spermatogenic cell death in vitro

Archives of Histology and Cytology

Volumn 67, Issue 4, 2004, Pages 315-324

  Tres, Laura L ^a   Rosselot, Carolina ^a   Kierszenbaum, Abraham L ^a  

^a CITY UNIVERSITY OF NEW YORK MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; CASPASE 4; F ACTIN; GROWTH FACTOR; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; CELL DIFFERENTIATION; CELL MEMBRANE PERMEABILITY; CELL VIABILITY; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; FLUORESCENCE MICROSCOPY; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; MALE; NEWBORN; NONHUMAN; RAT; SEMINIFEROUS TUBULE EPITHELIUM; SERTOLI CELL; SPERMATOCYTE; SPERMATOGONIUM;

ACTINS; ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; CASPASES; CELL SURVIVAL; CELLS, CULTURED; COCULTURE TECHNIQUES; CULTURE MEDIA, SERUM-FREE; CYTOSKELETON; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GROWTH HORMONE; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, VIDEO; PHAGOCYTOSIS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; SERTOLI CELLS; SPERMATOZOA; TIME FACTORS;

EID: 13444293077     PISSN: 09149465     EISSN: None     Source Type: Journal    
DOI: 10.1679/aohc.67.315     Document Type: Conference Paper

References (24)

1. Dunkel L, Hirvonen V, Erkkila K: Clinical aspects of male germ cell apoptosis during testis development and spermatogenesis. Cell Death Diff 4: 171-179 (1997).
2. Ferraro E, Corvaro M, Cecconi F: Physiological and pathological roles of Apaf1 and the apoptosome. J Cell Mol Med 7: 21-34 (2003).
3. French LE, Hahne M, Viard I, Radlgruber G, Zanone R, Becker K, Muller C, Tschopp J: Fas and Fas ligand in embryos and adult mice: ligand expression in several immune-privileged tissues and coexpression in adult tissues characterized by apoptotic cell turn-over. J Cell Biol 133: 335-343 (1996).
4. Furuchi T, Masuko K, Nishimune Y, Obinata M, Matsui Y: Inhibition of testicular germ cell apoptosis and differentiation in mice misexpressing Bcl-2 in spermatogonia. Development 122: 1703-1709 (1996).
5. Garcia-Calvo M, Peterson EP, Leiting B, Ruel R, Nicholson DW, Thornberry NA: Inhibition of human caspases by peptide-based and macromolecular inhibitors. J Biol Chem 273: 32608-32613 (1998).
6. Huckins C: The morphology and kinetics of spermatogonial degeneration in normal adult rats: an analysis using a simplified classification of germinal epithelium. Anat Rec 190: 905-926 (1978).
7. Kerr JB: Spontaneous degeneration of germ cells in normal rat testis: assessment of cell types and frequency during the spermatogenic cycle. J Reprod Fert 95: 825-830 (1992).
8. Kierszenbaum AL: Mammalian spermatogenesis in vivo and in vitro: a partnership of spermatogenic and somatic cell lineages. Endocr Rev 15: 116-134 (1994).
9. Knudson CM, Korsmeyer SJ: Bcl-2 and Bax function independently to regulate cell death. Nat Genet 16: 358-363 (1997).
10. Knudson CM, Tung KS, Turtellotte WG, Brown GA, Korsmeyer SJ: Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science 270: 96-88 (1995).
11. Lauber K, Blumenthal SG, Waibel M, Wesselborg S: Clearance of apoptotic cells: getting rid of the corpses. Mol Cell 14: 277-287 (2004).
12. Lee J, Richburg JH, Younkin SC, Boeckelheide H: The Fas system is a key regulator of germ cell apoptosis in the testis. Endocrinology 138: 2082-2088 (1997).
13. Marh J, Tres LL, Yamazaki Y, Yanagimachi R, Kierszenbaum AL: Mouse round spermatids developed in vitro from preexisting spermatocytes can produce normal offspring by nuclear injection into in vivo-developed mature oocytes. Biol Reprod 69: 169-176 (2003).
14. Nagata S: Apoptosis by death factor. Cell 88: 355-365 (1997).
15. Rodriguez I, Ody C, Araki K, Garcia I, Vassalli P: An early and massive wave of germinal cell apoptosis is required for the development of functional spermatogenesis. EMBO J 16: 2262-2270 (1997).
16. Rosselot C, Kierszenbaum AL, Rivkin E, Tres LL: Chronological gene expression of ADAMs during testicular development: prespermatogonia (gonocytes) express fertilin β (ADAM2). Dev Dyn 227: 458-67 (2003).
17. Sanberg PR, Saporta S, Borlongan CV, Othberg AI, Allen RC, Cameron DF: The testis-derived cultured Sertoli cell as a natural Fas-L secreting cell for immunosuppressive cellular therapy. Cell Transplant 6: 191-193 (1997).
18. Shiratsuchi A, Umeda M, Ohba Y, Nakanishi Y: Recognition of phosphatidyl serine on the surface of apoptotic spermatogenic cells and subsequent phagocytosis by Sertoli cells of the rat. J Biol Chem 272: 2354-235 (1997).
19. Suzuki A, Matsuzawa A, Iguchi T: Down regulation of Bcl-2 is the first step on Fas-mediated apoptosis of male reproductive tract. Oncogene 13: 31-37 (1996).
20. Tapainanen JS, Tilly JL, Vihko KK, Haueh AJ: Hormonal control of apoptotic cell death in the testis: gonadotropins and androgens as testicular cell survival factors. Mol Endocrinol 7: 643-650 (1993).
21. Thornberry NA, Lazebnik Y: Caspases: enemies within. Science 281: 1312-1316 (1998).
22. Tres LL, Kierszenbaum AL: Viability of rat spermatogenic cells in coculture in vitro is facilitated by their coculture with Sertoli cells in serum-free, hormone-supplemented medium. Proc Natl Acad Sci USA 80: 3377-3381 (1983).
23. Tres LL, Kierszenbaum AL: Cell death patterns of the rat spermatogonial cell progeny induced by Sertoli cell geometric changes and Fas (CD95) agonist. Dev Dyn 1999; 21: 361-371 (1999).
24. Tres LL, Smith FF, Kierszenbaum AL: Spermatogenesis in vitro: methodological advances and cellular functional parameters. In: Reproduction, growth, and development (Negro Vilar A, Perez Palacios G, ed), Raven Press, New York, 1991 (p.115-125).