Novel small peptides with neuroprotective and nootropic properties

Journal of Alzheimer's Disease

Volumn 6, Issue SUPPL., 2004, Pages

  Faden, Alan I ^a   Knoblach, Susan M ^a   Movsesyan, Vilen A ^a   Cernak, Ibolja ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AQUAPORIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CATHEPSIN; CYTOCHROME C; DIPEPTIDE; GLUTAMIC ACID; HEAT SHOCK PROTEIN; HYPOXIA INDUCIBLE FACTOR 1; NEUROPROTECTIVE AGENT;

APOPTOSIS; ARTICLE; BRAIN INJURY; CALCIUM CELL LEVEL; COGNITION; DNA MICROARRAY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME RELEASE; NERVE CELL CULTURE; NERVE CELL LESION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL;

EID: 13444274643     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/jad-2004-6s603     Document Type: Article

References (18)

1. A.I. Faden, Neuroprotection and traumatic brain injury: theoretical option or realistic proposition, Curr Opin Neurol 15 (2002), 707-712.
2. M.B. Bracken and T.R. Holford, Effects of timing of methylprednisolone or naloxone administration on recovery of segmental and long-tract neurological function in NASCIS 2, J Neurosurg 79 (1993), 500-507.
3. L.H. Pitts, A. Ross, G.A. Chase and A.I. Faden, Treatment with thyrotropin-releasing hormone (TRH) in patients with traumatic spinal cord injuries, J Neurotrauma 12 (1995), 235-243.
4. A.I. Faden, Pharmacological treatment approaches for brain and spinal cord trauma, in: Neurotrauma, R.K. Narayan, J.E. Wilberger and J.T. Povlishock, eds, New York: McGraw-Hill, 1996, pp. 1479-1490.
5. D.L. Behrmann, J.C. Bresnahan and M.S. Beattie, Modeling of acute spinal cord injury in the rat: neuroprotection and enhanced recovery with methylprednisolone, U-74006F and YM-14673, Exp Neurol 126 (1994), 61-75.
6. M.A. Puniak, G.M. Freeman, C.A. Agresta, L. Van Newkirk, C.A. Barone and S.K. Salzman, Comparison of a serotonin antagonist, opioid antagonist, and TRH analog for the acute treatment of experimental spinal trauma, J Neurotrauma 8 (1991), 193-203.
7. A.I. Faden, T.P. Jacobs, M.T. Smith and J.W. Holaday, Comparison of thyrotropin-releasing hormone (TRH), naloxone, and dexamethasone treatments in experimental spinal injury, Neurology 33 (1983), 673-678.
8. A.I. Faden, V.M. Labroo and L.A. Cohen, Imidazole-substituted analogues of TRH limit behavioral deficits after experimental brain trauma, J Neurotrauma 10 (1993), 101-108.
9. A.I. Faden, G.B. Fox, L. Fan, G.L. Araldi, L. Qiao, S. Wang and A.P. Kozikowski, Novel TRH analog improves motor and cognitive recovery after traumatic brain injury in rodents, Am J Physiol 277 (1999), R1196-1204.
10. T.K. McIntosh, R. Vink and A.I. Faden, An analogue of thyrotropin-releasing hormone improves outcome after brain injury: 31P-NMR studies, Am J Physiol 254 (1988), R785-792.
11. L.O. Koskinen, Effect of low intravenous doses of TRH, acid-TRH and cyclo(His-Pro) on cerebral and peripheral blood flows, Br J Pharmacol 87 (1986), 509-519.
12. R. Vink, T.K. McIntosh and A.I. Faden, Treatment with the thyrotropin-releasing hormone analog CG3703 restores magnesium homeostasis following traumatic brain injury in rats, Brain Res 460 (1988), 184-188.
13. C. Prasad, Bioactive cyclic dipeptides, Peptides 16 (1995), 151-164.
14. A.I. Faden, S.M. Knoblach, I. Cernak, L. Fan, R. Vink, G.L. Araldi, S.T. Fricke, B.L. Roth and A.P. Kozikowski, Novel diketopiperazine enhances motor and cognitive recovery after traumatic brain injury in rats and shows neuroprotection in vitro and in vivo, J Cereb Blood Flow Metab 23 (2003), 342-354.
15. A.I. Faden, G.B. Fox, X. Di, S.M. Knoblach, I. Cernak, P. Mullins, M. Nikolaeva and A.P. Kozikowski, Neuroprotective and nootropic actions of a novel cyclized dipeptide after controlled cortical impact injury in mice, J Cereb Blood Flow Metab 23 (2003), 355-363.
16. J.W. Allen, B.A. Eldadah, X. Huang, S.M. Knoblach and A.I. Faden, Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis, J Neurosci Res 65 (2001), 45-53.
17. A.I. Faden, P. Demediuk, S.S. Panter and R. Vink, The role of excitatory amino acids and NMDA receptors in traumatic brain injury, Science 244 (1989), 798-800.
18. D.I. Graham, S.M. Gentleman, J.A. Nicoll, M.C. Royston, J.E. McKenzie, G.W. Roberts, R.E. Mrak and W.S. Griffin, Is there a genetic basis for the deposition of beta-amyloid after fatal head injury? Cell Mol Neurobiol 19 (1999), 19-30.