Duration of effect and effect of multiple doses of topical ophthalmic 0.5% proparacaine hydrochloride in clinically normal dogs

American Journal of Veterinary Research

Volumn 66, Issue 1, 2005, Pages 77-80

  Herring, Ian P ^a   Bobofchak, Mark A ^a,b   Landry, Matthew P ^a,c   Ward, Daniel L ^a  

^a VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

^b Eye Care For Animals   (United States)

^c Department of Obstetrics Gynecology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EYE DROPS; LOCAL ANESTHETIC AGENT; PROCAINE; PROXYMETACAINE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORNEA SENSIBILITY; DRUG ACTIVITY; DRUG EFFECT; FEMALE; MALE; MULTIPLE DRUG DOSE; NONHUMAN; PERCEPTIVE THRESHOLD; SINGLE DRUG DOSE; TOPICAL ANESTHESIA;

ADMINISTRATION, TOPICAL; ANESTHETICS, LOCAL; ANIMALS; CORNEA; DOGS; OPHTHALMIC SOLUTIONS; PROPOXYCAINE; TIME FACTORS;

ANIMALIA; CANIS FAMILIARIS;

EID: 13444269293     PISSN: 00029645     EISSN: None     Source Type: Journal    
DOI: 10.2460/ajvr.2005.66.77     Document Type: Article

References (24)

1. Gelatt KN, Peiffer RL Jr, Erickson JL, et al. Evaluation of tear formation in the dog, using a modification of the Schirmer tear test. J Am Vet Med Assoc 1975;166:368-370.
2. Hamor RE, Roberts SM, Severin GA, et al. Evaluation of results for Schirmer tear tests conducted with and without application of a topical anesthetic in clinically normal dogs of 5 breeds. Am J Vet Res 2000;61:1422-1425.
3. Magrane WG. Investigational use of ophthaine as a local anesthetic in ophthalmology. North Am Vet 1953;53:568-569.
4. Ward DA. Clinical ophthalmic pharmacology and therapeutics. Part 3. In: Gelatt KN, ed. Veterinary ophthalmology. 3rd ed. Baltimore: Lippincott Williams & Wilkins Co, 1999;336-354.
5. Forstom C. Ophthaine (proparacaine hydrochloride): a local anesthetic for ophthalmic surgery (lett). Vet Rec 1964;76:385.
6. Slatter D. Ocular pharmacology and therapeutics. In: Slatter DH, ed. Fundamentals of veterinary ophthalmology. 3rd ed. Philadelphia: WB Saunders Co, 2001;34-67.
7. Stiles J, Krohne S, Rankin A, et al. The efficacy of 0.5% proparacaine stored at room temperature. Vet Ophthalmol 2001; 4:205-207.
8. Barrett PM, Scagliotti RH, Meredith RE, et al. Absolute corneal sensitivity and corneal trigeminal nerve anatomy in normal dogs. Prog Vet Comp Ophthalmol 1991;1:245-254.
9. Polse KA, Keener RJ, Jauregui MJ. Dose-response effects of corneal anesthetics. Am J Optom Physiol Opt 1978;55:8-14.
10. Nomura K, Singer DE, Aquavella JV. Corneal sensation after topical anesthesia. Cornea 2001;20:191-193.
11. Weigt AK, Herring IP, Marfurt CF, et al. Effects of cyclophotocoagulation with a neodymium:yttrium-aluminum-garnet laser on corneal sensitivity, intraocular pressure, aqueous tear production, and corneal nerve morphology in eyes of dogs. Am J Vet Res 2002; 63:906-915.
12. Liu JC, Steinemann TL, McDonald MB, et al. Topical bupivacaine and proparacaine: a comparison of toxicity, onset of action, and duration of action. Cornea 1993;12:228-232.
13. Bartfield JM, Holmes TJ, Raccio-Robak N. A comparison of proparacaine and tetracaine eye anesthetics. Acad Emerg Med 1994; 1:364-367.
14. Boozan CW, Cohen IJ. Ophthaine: a new topical anesthetic for the eye. Am J Ophthalmol 1953;36:1619-1621.
15. Weiss JS, Goren MB. The effect of corneal hypesthesia on the duration of proparacaine anesthetic eyedrops. Am J Ophthalmol 1991;112:326-330.
16. Good KL, Maggs DJ, Hollingsworth SR, et al. Corneal sensitivity in dogs with diabetes mellitus. Am J Vet Res 2003;64:7-11.
17. Strichartz G. Molecular mechanisms of nerve block by local anesthetics. Anesthesiology 1976;45:421-441.
18. Adriani J, Zepernick R, Arens J, et al. The comparative potency and effectiveness of topical anesthetics in man. Clin Pharmacol Ther 1964;45:49-62.
19. Glasser DB, Gardner S, Ellis JG, et al. Loading doses and extended dosing intervals in topical gentamicin therapy. Am J Ophthalmol 1985;99:329-332.
20. Matsumoto S, Hayashi K, Tsuchisaka H, et al. Pharmacokinetics of surface anesthetics in the human cornea. Jpn J Ophthalmol 1981;25:335-340.
21. Patton TF, Robinson JR. Influence of topical anesthesia on tear dynamics and ocular drug bioavailability in albino rabbits. J Pharm Sci 1975;64:267-271.
22. Brooks DE, Clark CK, Lester GD. Cochet-Bonnet aesthesiometer-determined corneal sensitivity in neonatal foals and adult horses. Vet Ophthalmol 2000;3:133-137.
23. Blocker T, Van Der Woerdt A. A comparison of corneal sensitivity between brachycephalic and domestic short-haired cats. Vet Ophthalmol 2001;4:127-130.
24. Millodot M, O'Leary DJ. Corneal fragility and its relationship to sensitivity. Acta Ophthalmol (Copenh) 1981;59:820-826.