Insulin resistance determines efficacy of glimepiride in type 2 diabetic patients not well controlled by diet alone [2]

Diabetic Medicine

Volumn 22, Issue 2, 2005, Pages 225-226

  Shimizu, Hiroyuki ^a   Monden, Takeshi ^a   Nagai, Takashi ^a   Shoda, Yoshihito ^a   Sato, Tetsurou ^a   Yamada, Masanobu ^a   Mori, Masatomo ^a  

^a GUNMA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDIABETIC AGENT; GLIMEPIRIDE; INSULIN; SULFONYLUREA;

ADULT; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETES CONTROL; DIABETIC DIET; DISEASE DURATION; DRUG EFFECT; DRUG EFFICACY; DRUG INDICATION; DRUG RESPONSE; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; HUMAN; HYPOGLYCEMIA; INSULIN RESISTANCE; LETTER; MALE; METABOLIC PARAMETERS; MONOTHERAPY; MULTICENTER STUDY; NON INSULIN DEPENDENT DIABETES MELLITUS; OPEN STUDY; TREATMENT OUTCOME; TRIACYLGLYCEROL BLOOD LEVEL; WEIGHT GAIN;

EID: 13444267578     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2005.01380.x     Document Type: Letter

References (5)

1. Rosak C. The pathophysiologic basis of efficacy and clinical experience with the new oral antidiabetic agents. J Diabetes Complications 2002; 16: 123-132.
2. Muller G, Wied S. The sulfonylurea drug, glimepitide, stimulates glucose transport, glucose transporter translocation, and dephosphorylation in insulin-resistant adipocytes in vitro. Diabetes 1993; 42: 852-867.
3. Langtry HD, Balfour JA. A review of its use in the management of type 2 diabetes mellitus. Drug 1998; 55: 563-584.
4. Charpentier G, Vaur L, Halimi S, Fleury F, Derobert E, Grimaldi A et al.; DIAMETRE. Predictors of response to glimepiride in patients with type 2 diabetes mellitus. Diabetes Metab 2001; 27: 563-571.
5. Gurnell M, Savage DB, Chatterjee VKK, O'Rahilly S. The metabolic syndrome: proliferator-activated receptor γ and its therapeutic modulation. J Endocrinol Metab 2003; 88: 2412-2421.