Structural basis of nonnatural amino acid recognition by an engineered aminoacyl-tRNA synthetase for genetic code expansion

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 5, 2005, Pages 1366-1371

  Kobayashi, Takatsugu ^a   Sakamoto, Kensaku ^a,b   Takimura, Tetsuo ^c   Sekine, Ryo ^c,d   Vincent, Kelly ^c,e   Kamata, Kenji ^c   Nishimura, Susumu ^c   Yokoyama, Shigeyuki ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b RIKEN YOKOHAMA INSTITUTE   (Japan)

^c Banyu Pharmaceutical Co   (Japan)

^d Etagon   (United States)

^e TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

3 iodo L tyrosine; Crystal structure; Tyrosyl tRNA synthetase

Indexed keywords

AMINO ACID; AMINO ACID TRANSFER RNA LIGASE; CYSTEINE; IODINE; IODOTYROSINE; SULFUR; TYROSINE; VALINE;

AMINOACYLATION; ARTICLE; ENZYME ACTIVE SITE; ENZYME ENGINEERING; ESCHERICHIA COLI; GENE MUTATION; GENETIC CODE; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; RNA TRANSLATION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO ACIDS; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; GENETIC CODE; GENETIC ENGINEERING; HYDROGEN BONDING; MODELS, MOLECULAR; MONOIODOTYROSINE; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TYROSINE-TRNA LIGASE;

ESCHERICHIA COLI; EUKARYOTA;

EID: 13444265892     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0407039102     Document Type: Article

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