Positive inotropic effect of nicorandil in adult rats in situ

Journal of Anesthesia

Volumn 19, Issue 1, 2005, Pages 45-53

  Nakahashi, Kazuyoshi ^a   Kitagawa, Yutaka ^a   Ito, Haruo ^a   Kuzumoto, Naoya ^a   Furuya, Hitoshi ^a   Takaki, Miyako ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

Author keywords

Cardiac function; End systolic pressure volume relationship; Inotropic agent; KATPchannels; Systolic pressure volume area (PVA)

Indexed keywords

5 HYDROXYDECANOIC ACID; GLIBENCLAMIDE; GLYCERYL TRINITRATE; NICORANDIL; NITRIC OXIDE DONOR; POTASSIUM CHANNEL BLOCKING AGENT;

ANIMAL EXPERIMENT; ARTERY COMPLIANCE; ARTICLE; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG EFFECT; HEART AFTERLOAD; HEART CATHETER; HEART LEFT VENTRICLE CONTRACTILITY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE PRESSURE; HEART LEFT VENTRICLE VOLUME; HEART LEFT VENTRICLE WORK; HEART MUSCLE FIBER MEMBRANE CONDUCTANCE; HEART PRELOAD; HEART RATE; HEART STROKE VOLUME; HEART VENTRICLE ENDDIASTOLIC PRESSURE; INOTROPISM; MALE; MANOMETER; NONHUMAN; PRESSURE VOLUME CURVE; RAT; STEADY STATE; SYSTOLIC BLOOD PRESSURE;

ALGORITHMS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BLOOD VOLUME; CARDIOTONIC AGENTS; HEMODYNAMIC PROCESSES; INFUSIONS, INTRAVENOUS; MALE; NICORANDIL; NITROGLYCERIN; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; RATS, WISTAR; STROKE VOLUME; VASODILATOR AGENTS; VENTRICULAR FUNCTION, LEFT;

EID: 13444258029     PISSN: 09138668     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00540-004-0268-y     Document Type: Article

References (27)

1. Berdeaux A, Drieu la Rochelle C, Richard V, Giudicelli JF (1992) Differential effects of nitrovasodilators, K channel openers and nicorandil on large and small coronary arteries in conscious dogs. J Cardiovasc Pharmacol 20(suppl 3):S17-S21
2. Nishikawa Y, Kanki H, Ogawa S (1998) Differential effects of N-acetylcysteine on nitroglycerin- and nicorandil-induced vasodilation in human coronary circulation. J Cardiovasc Pharmacol 32:21-28
3. Hashimoto K, Kinoshita M, Ohbayashi Y (1991) Coronary effects of nicorandil in comparison with nitroglycerin in chronic conscious dogs. Cardiovasc Drugs Ther 5:131-138
4. Humphrey SJ, Schwende FJ (1995) Cardiovascular interactions characterizing the vasodilator components of nicorandil in conscious dogs. J Cardiovasc Pharmacol 26:810-821
5. Müller-Ehmsen J, Brixius K, Hoischen S, Schwinger RHG (1996) Inotropic and coronary vasodilatory actions of the K-adenosine triphosphate channel modulator nicorandil in human tissue. J Pharmacol Exp Ther 279:1220-1228
6. Kamijo T, Kamei K, Sugo I, Kamiyama T, Sudo H, Ohba Y (1999) Hemodynamic and hormonal responses to nicorandil in a canine model of acute ischemic heart failure: A comparison with cromakalim and nitroglycerin. J Cardiovasc Pharmacol 33:93-101
7. Noguchi K, Matsuzaki T, Ojiri Y, Koyama T, Nakasone J, Sakanashi M (1998) Beneficial hemodynamic effects of nicorandil in a canine model of acute congestive heart failure: Comparison with nitroglycerin and cromakalim. Fundam Clin Pharmacol 12:270-278
8. 2 use of the excised blood-perfused rat heart. J Mol Cell Cardiol 30:2137-2143
9. 2 use-pressure-volume area relation from curved end-systolic pressure-volume relation of the blood-perfused rat left ventricle. Jpn J Physiol 48:197-204
10. Tsuji T, Ohga Y, Yoshikawa Y, Sakata S, Kohzuki H, Misawa H, Abe T, Tabayashi N, Kobayashi S, Kitamura S, Taniguchi S, Suga H, Takaki M (1999) New index for oxygen cost of contractility from curved end-systolic pressure-volume relations in cross-circulated rat hearts. Jpn J Physiol 49:513-520
11. Lee S, Ohga Y, Tachibana H, Syuu Y, Ito H, Harada M, Suga H, Takaki M (1998) Effects of myosin isozyme shift on curvilinearity of the left ventricular end-systolic pressure-volume relation of in situ rat hearts. Jpn J Physiol 48:445-455
12. Tachibana H, Takaki M, Lee S, Ito H, Yamaguchi H, Suga H (1997) New mechanoenergetic evaluation of left ventricular contractility in in situ rat hearts. Am J Physiol Heart Circ Physiol 272:H2671-H2678
13. Kameyama T, Chen Z, Bell SP, Fabian J, LeWinter MM (1998) Mechanoenergetic studies in isolated mouse hearts. Am J Physiol Heart Circ Physiol 274:H366-H374
14. Takaki M, Matsubara H, Araki J, Zhao LY, Ito H, Yasuhara S, Fujii W, Suga H (1996) Mechanoenergetics of acute failing hearts characterized by oxygen costs of mechanical energy and contractility. In: Sasayama S (ed) New horizons for failing heart syndrome. Springer, Tokyo, pp 133-164
15. Kishi T, Nakahashi K, Ito H, Taniguchi S, Takaki M (2001) Effects of milrinone on left ventricular end-systolic pressure-volume relation of in situ rat hearts. Clin Exp Pharmacol Physiol 28:737-742
16. Sunagawa K, Maughan WL, Burkhoff D, Sagawa K (1983) Left ventricular interaction with arterial load studied in isolated canine heart. Am J Physiol Heart Circ Physiol 245:H773-H780
17. Sunagawa K, Maughan WL, Sagawa K (1985) Optimal arterial resistance for the maximal stroke work studied in isolated canine left ventricle. Circ Res 56:586-595
18. Ito H, Takaki M, Yamaguchi H, Tachibana H, Suga H (1996) Left ventricular volumetric conductance catheter for rats. Am J Physiol Heart Circ Physiol 270:H1509-H1514
19. Baan J, Aouw Jong TT, Kerkhof PLM, Moene RJ, van Dijk AD, van der Velde ET, Koops J (1981) Continuous stroke volume and cardiac output from intra-ventricular dimensions obtained with impedance catheter. Cardiovasc Res 15:328-334
20. Baan J, van der Velde ET, De Bruin HG, Smeenk GJ, Koops J, van Dijk AD, Temmerman D, Senden J, Buis B (1984) Continuous measurement of left ventricular volume in animals and humans by conductance catheter. Circulation 70:812-823
21. Suga H (1990) Ventricular energetics. Physiol Rev 70:247-277
22. + channels modulate cardiac mitochondrial function. Am J Physiol Heart Circ Physiol 275:H1567-H1576
23. 2+ overload in rat cardiac mitochondria. J Physiol 519:347-360
24. + channel of heart mitochondria. Am J Physiol Heart Circ Physiol 280:H649-H657
25. ATP channel-independent targets of diazoxide and 5-hydroxydecanoate in the heart. J Physiol 542:735-741
26. Namba T, Takaki M, Araki J, Ishioka K, Suga H (1994) Energetics of the negative and positive inotropism of pentobarbital sodium in the canine left ventricle. Cardiovasc Res 28:557-564
27. Freeman GL, Little WC, O'Rourke RA (1987) Influence of heart rate on left ventricular performance in conscious dogs. Circ Res 61:455-464