Does god play dice with schizophrenia? A probabilistic model for the understanding of causation in mental illness

Medical Hypotheses

Volumn 64, Issue 4, 2005, Pages 872-877

  Procopio, Marco ^a,b  

^a Southgate   (United Kingdom)

^b UNIVERSITY OF BRIGHTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; ENVIRONMENTAL FACTOR; GENETIC PREDISPOSITION; GENETIC RISK; HIGH RISK POPULATION; HUMAN; MEDICAL RESEARCH; MENTAL DISEASE; NERVE CELL DIFFERENTIATION; PRIORITY JOURNAL; PROBABILITY; QUANTUM CHEMISTRY; SCHIZOPHRENIA; STATISTICAL MODEL;

EID: 13444256306     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mehy.2004.10.007     Document Type: Article

References (26)

1. E. Kraepelin Lehrbuch der psychiatrie 5th ed. 1896 Barth Leipzig p. 426-41
2. J. Haslam Observations on madness and melancholy 2nd ed. 1809 Callow London
3. I.I. Gottesman, and J. Shields Schizophrenia: the epigenetic puzzle 1982 Cambridge University Press Cambridge
4. K.S. Kendler, C.C. Masterson, and K.L. Davis Psychiatric illness in first-degree relatives of patients with paranoid psychosis, schizophrenia and medical illness Br J Psychiat 147 1985 524 531
5. E.S. Gershon, L.E. De Lisi, J. Hamovit, and J.I. Nurnberger Jr. A controlled family study of chronic psychoses: schizophrenia and schizoaffective disorder Arch Gen Psychiat 45 4 1988 328 336
6. I.I. Gottesman Schizophrenia genesis: the origins of madness 1991 W.H. Freeman New York
7. A.E. Farmer, P. McGuffin, and I.I. Gottesman Twin concordance for DSM-III schizophrenia: scrutinising the validity of the definition Arch Gen Psychiat 44 1987 634 640
8. T.D. Cannon, J. Kaprio, J. Lonnqvist, M. Huttunen, and M. Koskenvuo The genetic epidemiology of schizophrenia in a finnish twin cohort: a population-based modelling study Arch Gen Psychiat 55 1998 67 74
9. A.G. Cardno, E.J. Marshall, B. Coid, A.M. Macdonald, T.R. Ribchester, and N.J. Davies Heritability estimates for psychotic disorders: the Maudsley twin psychosis series Arch Gen Psychiat 56 1999 162 168
10. L.L. Heston Psychiatric disorders in foster home reared children of schizophrenic mothers Br J Psychiat 112 1996 819 825
11. D.R. Weinberger Implications of normal brain development for the pathogenesis of schizophrenia Arch Gen Psychiat 44 1987 660 669
12. R.M. Murray, S.W. Lewis, M.J. Owen, and A. Foerster The neurodevelopmental origins of dementia praecox P. Bebbington P. McGuffin Schizophrenia: the major issues 1988 Heinemann London 90 106
13. S.A. Mednick, T.D. Cannon, C. Barr, and M. Lyon Fetal neural development and adult schizophrenia 1991 Cambridge University Press Cambridge
14. E.F. Torrey, J. Miller, R. Rawlings, and R.H. Yolken Seasonality of birth in schizophrenia and bipolar disorder: a review of the literature Schizophr Res 28 1997 1 38
15. P.B. Mortensen, C.B. Pedersen, T. Westergaard, J. Wohlfahrt, H. Ewald, and O. Mors Effects of family history and place and season of birth on the risk of schizophrenia New Engl J Med 340 8 1999 603 608
16. J.R. Geddes, H. Verdoux, N. Takei, S.M. Lawrie, P. Bovet, and J.M. Eagles Schizophrenia and complications of pregnancy and labour: an individual patient data meta-analysis Schizophr Bull 25 3 1999 413 423
17. C.G. Watson, T. Kucala, C. Tilleskjor, and L. Jacobs Schizophrenic birth seasonality in relation to the incidence of infectious diseases and temperature extremes Arch Gen Psychiat 41 1984 85 90
18. E. Susser, R. Neugebauer, H.W. Hoek, A.S. Brown, S. Lin, and D. Labovitz Schizophrenia after pre-natal famine: further evidence Arch Gen Psychiat 53 1 1996 25 31
19. D.H. O'Rourke, I.I. Gottesman, B.K. Suarez, J. Rice, and T. Reich Refutation of the general single-locus model for the etiology of schizophrenia Am J Hum Genet 34 1982 630 649
20. M. McGue, I. Gottesman, and D.C. Rao Resolving genetic models for the transmission of schizophrenia Genet Epidemiol 2 1985 99 110
21. P. McGuffin Models of heritability and genetic transmission H. Hafner W. Gattaz Search for the causes of schizophrenia, vol. 2 1990 Springer-Verlag Heidelberg
22. D.S. Falconer The inheritance of liability to certain diseases, estimated from the incidence among relatives Ann Hum Genet 29 1965 51 76
23. I.I. Gottesman, and J. Shields A polygenic theory of schizophrenia Proc Nat Acad Sci USA 58 1967 199 205
24. P. McGuffin, and R. Murray The new genetics of mental illness 1991 Butterworth-Heinemann Oxford
25. K.S. Kendler, and L.J. Eaves Models for the joint effect of genotype and environment on liability to psychiatric illness Am J Psychiat 143 1986 279 289
26. Einstein A. Letter to Max Born. In: Einstein und Born Briefwechsel; 1926