Efficacy of fluticasone on cough: A randomised controlled trial

European Respiratory Journal

Volumn 25, Issue 1, 2005, Pages 147-152

  Ponsioen, B P ^a   Hop, W C J ^a   Vermue, N A ^b   Dekhuijzen, P N R ^c   Bohnen, A M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b GLAXOSMITHKLINE   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Adults; Cough; Fluticasone; Primary care; Smoking

Indexed keywords

ANTIINFLAMMATORY AGENT; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; DEXTROMETHORPHAN; FLUTICASONE PROPIONATE; PLACEBO; STEROID;

ADULT; AGED; ARTICLE; BRONCHUS HYPERREACTIVITY; CANDIDIASIS; CLINICAL TRIAL; COMMUNITY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; COUGHING; DISEASE DURATION; DOSE TIME EFFECT RELATION; DOUBLE BLIND PROCEDURE; DRUG DOSE REGIMEN; DRUG EFFICACY; FEMALE; FORCED EXPIRATORY VOLUME; HEALTH CENTER; HOARSENESS; HUMAN; LOWER RESPIRATORY TRACT; MAJOR CLINICAL STUDY; MALE; MEDICAL DOCUMENTATION; MOUTH INFECTION; OUTCOMES RESEARCH; PARALLEL DESIGN; PHARYNGITIS; PRIMARY HEALTH CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT DISEASE; SCORING SYSTEM; SHORT COURSE THERAPY; SMOKING; STATISTICAL SIGNIFICANCE;

ADMINISTRATION, INHALATION; ADOLESCENT; ADULT; AGED; ANDROSTADIENES; ANTI-INFLAMMATORY AGENTS; BRONCHIAL HYPERREACTIVITY; CHRONIC DISEASE; COUGH; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PROBABILITY; REFERENCE VALUES; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME;

EID: 13444254370     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.04.00053604     Document Type: Article

References (30)

1. Corne JM, Marshall C, Smith S, et al. Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study. Lancet 2002; 359: 831-834.
2. Gibson PG, Fujimura M, Niimi A. Eosinophilic bronchitis: clinical manifestations and implications for treatment. Thorax 2002; 57: 178-182.
3. Trigg CJ, Nicholson KG, Wang JH, et al. Bronchial inflammation and the common cold: a comparison of atopic and non-atopic individuals. Clin Exp Allergy 1996; 26: 665-676.
4. Szefler SJ, Boushey HA, Pearlman DS, et al. Time to onset of effect of fluticasone propionate in patients with asthma. J Allergy Clin Immunol 1999; 103: 780-788.
5. Chalmers GW, Macleod KJ, Little SA, Thomson LJ, McSharry CP, Thomson NC. Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax 2002; 57: 226-230.
6. Rutgers SR, Koeter GH, van der Mark TW, Postma DS. Short-term treatment with budesonide does not improve hyperresponsiveness to adenosine 5′-monophosphate in COPD. Am J Respir Crit Care Med 1998; 157: 880-886.
7. Irwin RS, Madison JM. The diagnosis and treatment of cough. N Engl J Med 2000; 343: 1715-1721.
8. Macfarlane J, Holmes W, Gard P, et al. Prospective study of the incidence, aetiology and outcome of adult lower respiratory tract illness in the community. Thorax 2001; 56: 109-114.
9. Quanjer PH, Tammeling GJ, Cotes JE, Pedersen OF, Peslin R, Yernault JC. Lung volumes and forced ventilatory flows. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J 1993; 6: Suppl. 16, 5-40.
10. Lee PCL, Jawad MS, Eccles R. Antitussive efficacy of dextromethorphan in cough associated with acute upper respiratory tract infection. J Pharm Pharmacol 2000; 52: 1137-1142.
11. Tukiainen H, Karttunen P, Silvasti M, et al. The treatment of acute transient cough: a placebo-controlled comparison of dextromethorphan and dextromethorphan-beta 2-sympathomimetic combination. Eur J Respir Dis 1986; 69: 95-99.
12. Berkowitz RB, Connell JT, Dietz AJ, Greenstein SM, Tinkelman DG. The effectiveness of the nonsedating antihistamine loratadine plus pseudoephedrine in the symptomatic management of the common cold. Ann Allergy 1989; 63: 336-339.
13. Tattersfield AE, Knox AJ, Britton JR, Hall IP. Asthma. Lancet 2002; 360: 1313-1322.
14. Sterk PJ, Fabbri LM, Quanjer PH, et al. Airway responsiveness. Standardized challenge testing with pharmacological, physical and sensitising stimuli in adults. Report Working Party Standardization of Lung Function Tests, European Community for Steel and Coal. Official Statement of the European Respiratory Society. Eur Respir J Suppl 1993; 16: 53-83.
15. Evans AT, Husain S, Durairaj L, Sadowski LS, Charles-Damte M, Wang Y. Azithromycin for acute bronchitis: a randomised, double-blind, controlled trial. Lancet 2002; 359: 1648-1654.
16. Schroeder K, Fahey T. Systematic review of randomised controlled trials of over the counter cough medicines for acute cough in adults. BMJ 2002; 324: 329-331.
17. Smucny J, Fahey T, Becker L, Glazier R, McIsaac W. Antibiotics for acute bronchitis. Cochrane Database Syst Rev 2004; 4: CD000245.
18. Di Franco A, Dente FL, Giannini D, et al. Effects of inhaled corticosteroids on cough threshold in patients with bronchial asthma. Pulm Pharmacol Ther 2001; 14: 35-40.
19. French CT, Irwin RS, Fletcher KE, Adams TM. Evaluation of a cough-specific quality-of-life questionnaire. Chest 2002; 121: 1123-1131.
20. Birring SS, Prudon B, Carr AJ, Singh SJ, Morgan MD, Pavord ID. Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire (LCQ). Thorax 2003; 58: 339-343.
21. Freestone C, Eccles R. Assessment of the antitussive efficacy of codeine in cough associated with common cold. J Pharm Pharmacol 1997; 49: 1045-1049.
22. Ternesten-Hasseus E, Farbrot A, Lowhagen O, Millqvist E. Sensitivity to methacholine and capsaicin in patients with unclear respiratory symptoms. Allergy 2002; 57: 501-507.
23. Sovijarvi AR, Haahtela T, Ekroos HJ, et al. Sustained reduction in bronchial hyperresponsiveness with inhaled fluticasone propionate within three days in mild asthma: time course after onset and cessation of treatment. Thorax 2003; 58: 500-504.
24. Chinn S, Burney P, Jarvis D, Luczynska C. Variation in bronchial responsiveness in the European Community Respiratory Health Survey (ECRHS). Eur Respir J 1997; 10: 2495-2501.
25. Thiadens HA, de Bock GH, Dekker FW, et al. Identifying asthma and chronic obstructive pulmonary disease in patients with persistent cough presenting to general practitioners: descriptive study. BMJ 1998; 316: 1286-1290.
26. Green RH, Brightling CE, Wardlaw AJ, Pavord ID. Asthma exacerbations and sputum eosinophil counts. Lancet 2003; 361: 1303.
27. Wardlaw AJ, Brightling CE, Green R, Woltmann G, Bradding P, Pavord ID. New insights into the relationship between airway inflammation and asthma. Clin Sci (Lond) 2002; 103: 201-211.
28. Cox G, Whitehead L, Dolovich M, Jordana M, Gauldie J, Newhouse MT. A randomized controlled trial on the effect of inhaled corticosteroids on airways inflammation in adult cigarette smokers. Chest 1999; 115: 1271-1277.
29. Dicpinigaitis PV. Cough reflex sensitivity in cigarette smokers. Chest 2003; 123: 685-688.
30. Holmes WF, Macfarlane JT, Macfarlane RM, Hubbard R. Symptoms, signs, and prescribing for acute lower respiratory tract illness. Br J Gen Pract 2001; 51: 177-181.