Changes in methylmercury accumulation in the brain of rat offspring throughout gestation and during suckling

Toxicological and Environmental Chemistry

Volumn 86, Issue 1-4, 2004, Pages 161-168

  Huan, Sheng Pan ^a   Sakamoto, Mineshi ^b   Oliveira, R B ^c   Xiao, Jie Liu ^b   Kakita, Akiyoshi ^d   Futatsuka, Makoto ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE FOR MINAMATA DISEASE   (Japan)

^c FEDERAL UNIVERSITY OF PARÁ   (Brazil)

^d NIIGATA UNIVERSITY   (Japan)

Author keywords

Brain; Gestation; Methylmercury accumulation; Risk to offspring; Suckling

Indexed keywords

BIOLOGICAL ORGANS; BLOOD; BRAIN; TISSUE; TOXICITY;

GESTATION; LACTATING PERIODS; LACTATION; PARTURITION; PREGNANCY; SUCKLING;

MERCURY (METAL);

BIOACCUMULATION; METHYLMERCURY; RODENT;

EID: 13444252763     PISSN: 02772248     EISSN: None     Source Type: Journal    
DOI: 10.1080/02772240400007005     Document Type: Article

References (38)

1. Aaseth, J., Wannag, A. and Norseth, T. (1976). The effect of N-acetylated DL-penicillamine and DL-homocysteine thiolactone on the mercury distribution in adult rats, rat foetuses and Macaca monkeys after exposure to methyl mercury chloride. Acta Pharm. Toxicol., 39, 302-311.
2. Amin-zaki, L., Majeed, M.A., Greenwood, M.R., Elhassani, S.B., Clarkson, T.W.R. and Doherry, A. (1981). Methylmercury poisoning in the Iraqi suckling infant: a longitudinal study over five years. J. Appl. Exp. Toxicol., 1, 210-214.
3. Ashner, M. and Clarkson, T.W. (1988). Diatribution of mercury 203 in pregnant rats and their fetuses following systematic infusion with thiolcontaining amino acids and glutathione during late gestation. Teratology, 38, 145-155.
4. Choi, B.H. (1989). The effects of methylmercury on the developing brain. Prog. Neurobiol., 32, 447-470.
5. Dobbing, J. and Sands, J. (1979). Comparative aspects of the brain spurt. Early Hum. Dev., 3, 79-83.
6. Farquharson, J., Cockburn, F., Patric, W.A., Jamieson, E.C. and Logan, R.W. (1992). Infant cerebral cortex phospholipid fatty-acid composition and diet. Lancet, 340, 810-813.
7. Galster, W.A. (1976). Mercury in Alaskan Eskimo mothers and infants. Environ. Health Perspect., 15, 135-140.
8. Grandjean, P., Jørgensen, P.J. and Weihe, P. (1994). Human milk as a source of methylmercury exposure in infants. Environ. Health Perspect., 102, 74-77.
9. Harada, M. (1978). Congenital Minamata disease: intrauterine methylmercury poisoning. Teratology, 18, 285-288.
10. Jacobs, M.B., Yamaguchi, S., Goldwater, L.J. and Gilbert, H. (1960). Determination of mercury in blood. Am. Ind. Hyg. Assoc. J., 21, 475-480.
11. Kajiwara, Y., Yasutake, A., Adachi, T. and Hirayama, K. (1996). Methylmercury transport across the placenta via neutral amino acid carrier. Arch. Toxicol., 70, 310-314.
12. Kjellström, T., Kennedy, P., Willis, S. and Mantell, C. (1986). Physical and mental development of children with prenatal exposure to mercury from fish. Stage 1: preliminary test at age 4. Report 3080. National Swedish Environmental Protection Board, Stockholm.
13. Kosta, L., Byrne, A.R. and Dermelj, M. (1982). Trace elements in some human milk samples by radiochemical neutron activated analysis. Sci. Total Environ., 29, 261-268.
14. Kunz, C., Rodriguez-Palmero, M., Koletzko, B. and Jensen, R. (1999). Nutritional and biochemical properties of human milk, Part 1: General aspects, proteins, and carbohydrates. Clin. Perinatol., 26, 307-333.
15. Lewandowsky, T.A., Pierce, C.H., Pingree, S.D., Hong, S. and Faustman, E.M. (2002). Methylmercury distribution in the pregnant rat and embryo during early midbrain organogenesis. Teratology, 66, 235-241.
16. Lee, J.H. and Han, D.H. Maternal and fetal toxicity of methylmercuric chloride administered to pregnant Fisher 344 rats. J. Toxicol. Environ. Health, 45, 415-425.
17. Mansour M.M., Dyer, N.C., Hoffman, L.H., Davis, J. and Brill, A.B. (1974). Placental transfer of mercuric nitrate and methyl mercury in the rat. Am. J. Obstet. Gynecol, 119, 557-562.
18. Martinez, M. (1989). Dietary polyunsaturated fatty acids in relation to neural development in human. In: Galli, C. and Simopoulos, A.P. (Eds.), Dietary ω3 and ω6 Fatty Acids. Biological Effects and Nutritional Essentiality, pp. 123-33. Plenum Press, New York.
19. Newland, M.C. and Reile P.A. Blood and brain mercury levels after chronic gestational exposure to methylmercury in rats. Toxicol. Sci., 50, 101-116.
20. Nunes, J. and Ferreira, S. (2000). Possible mercury intoxication of newborns via breast milk. Front. Fetl. Health, 2, 18-20.
21. Oddy, W.H. (2001). Breastfeeding protects against illness and infection in infants and children. Breastfeed Rev., 9, 11-18.
22. Oliveira, R.B., Malm, O. and Guimarães, J.R.D. (2001). Distribution of methylmercury and inorganic mercury in neonate hamsters dosed with methylmercury during fetal life. Environ. Res. Section A, 86, 73-79.
23. Oskarsson, A., Hallën, I.P. and Sundberg, J. (1995). Exposure to toxic elements via breast milk. Analyst, 120, 765-770.
24. Oskarsson, A., Schüts, A., Skerfving, S., Hallën, I.P., Ohlin, B. and Lagerkvist, B.J. (1996). Total and inorganic mercury in breast milk and blood in relation to fish consumption and amalgam fillings in lactating women. Arch. Environ. Health, 51, 234-241.
25. Reuhl, K.R. and Chang, L.W. (1979). Effects of methylmercury on the development of the nervous system: a review. Neurotoxicol., 1, 21-55.
26. Rice, D.C. and Barone, S. (2000). Critical periods of vulnerability for developing nervous system: evidence from human and animal models. Environ. Health Perspect., 108, 511-533.
27. Sakamoto, M., Nakano, A., Kajiwara, Y., Naruse, I. and Fujisaki, T. (1993). Effects of methylmercury in postnatal developing rats. Environ. Res., 61, 43-50.
28. Sakamoto, M., Kakita, A., Wakabayashi, K., Nakano, A., Takahashi, H. and Akagi, H. (2002a). Evaluation of changes in methylmercury accumulation in the developing rat brain and its effects: a study with consecutive and moderate dose exposure through gestation and lactation periods. Brain Res., 949, 51-59.
29. Sakamoto, M., Kubota, M., Matsumoto, S., Nakano, A. and Akagi, H. (2002b). Declining risk of methylmercury exposure to infants during lactation. Environ. Res., 90, 185-189.
30. Skerfving, S. (1988). Mercury in women exposed to methylmercury through fish consumption, and in their newborn babies and breast milk. Bull. Environ. Contam. Toxicol., 41, 475-482.
31. Spitzer, A. (1985). The developing kidney and the progress of growth. In: Seldin, D.W. and Giebish, G. (Eds.), The Kidney, Physiology and Pathophysiology, pp. 1979-2015. Raven Press, New York.
32. Sundberg, J., Oskarsson, A. and Albanus, L. (1991). Methylmercury exposure during lactation: milk concentration and tissue uptake of mercury in the neonate rats. Bull. Environ. Contam. Toxicol., 46, 255-262.
33. Sundberg, J., Jönsson, S., Karlsson, M.O. and Oskarsson A. (1999). Lactation exposure and neonatal kinetics of methylmercury and inorganic mercury in mice. Toxicol. Appl. Phalmacol., 154, 160-169.
34. Takeuchi, T. (1968). Pathology of Minamata disease. In: Study Group of Minamata Disease (report) Minamata Disease, pp. 141-228. Kumamoto University, Kumamoto, Japan.
35. Takeuchi, T. (1982). Pathology of Minamata disease, with special reference to its pathogenesis. Acta Pathol. Jpn., 32 (Suppl. 1), 73-99.
36. Wannag, A. (1976). The importance of organ blood mercury when comparing foetal and maternal rat organ distribution after methyl mercury exposure. Acta Pharm. Toxicol., 38, 289-298.
37. World Health Organization (Eds.) (1990). IPCS. Environmental Health Criteria 101. Methylmercury. World Health Organization, Geneva.
38. Yoshida, M., Watanabe, C., Satoh, H., Kishimoto, T. and Yamamura, Y. (1994). Milk transfer and tissue uptake of mercury in suckling offspring after exposure of lactating maternal guinea pigs to inorganic or methylmercury. Arch. Toxicol., 68, 174-178.