Characteristics of radiogenic lower motor neurone disease, a possible link with a preceding viral infection

Spinal Cord

Volumn 42, Issue 2, 2004, Pages 99-105

  Esik O ^a,b   Vonoczky K ^b   Lengyel, Z ^c   Safrany G ^d   Tron L ^c,e  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b NATIONAL INSTITUTE OF ONCOLOGY   (Hungary)

^c UNIVERSITY OF DEBRECEN   (Hungary)

^d National Research Institute of Radiobiology and Radio Hygiene   (Hungary)

^e INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

Author keywords

Chemotherapy; Irradiation; Lower motor neurone disease; Viral infection

Indexed keywords

ADOLESCENT; ADULT; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; DISEASE COURSE; DOSE RESPONSE; ENTEROVIRUS INFECTION; FEMALE; HUMAN; INTOXICATION; IONIZING RADIATION; IRRADIATION; LEG; MALE; MOTOR NEURON DISEASE; NONHUMAN; PATHOGENESIS; POLIOMYELITIS VIRUS; PRIORITY JOURNAL; RADIOSENSITIVITY; REVIEW; RISK FACTOR; SEX DIFFERENCE; SPINAL CORD; VIRUS INFECTION;

ADOLESCENT; ADULT; AGE FACTORS; ANTERIOR HORN CELLS; CAUSALITY; CENTRAL NERVOUS SYSTEM VIRAL DISEASES; DRUG THERAPY; ENTEROVIRUS INFECTIONS; FEMALE; HUMANS; MALE; MIDDLE AGED; MOTOR NEURON DISEASE; NEOPLASMS; POLIOMYELITIS; RADIATION DOSAGE; RADIOTHERAPY; REACTION TIME; SEX FACTORS;

EID: 1342343953     PISSN: 13624393     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.sc.3101552     Document Type: Review

References (53)

1. Jellinger K, Sturm KW. Delayed radiation myelopathy in man. Report of twelve necropsy cases. J Neurol Sci 1971; 14: 389-408.
2. Kristensson K, Molin B, Sourander P. Delayed radiation lesions of the human spinal cord. Report of five cases. Acta Neuropathol 1967; 9: 34-44.
3. Palmer JJ. Radiation myelopathy. Brain 1972; 95: 109-122.
4. Reagan TJ, Thomas JE, Colby Jr MY. Chronic progressive radiation myelopathy. Its clinical aspects and differential diagnosis. JAMA 1968; 203: 128-132.
5. Schultheiss TE, Higgins EM, El-Mahdi AM. The latent period in clinical radiation myelopathy. Int J Radiat Oncol Biol Phys 1984; 10: 1109-1115.
6. Schultheiss TE, Stephens LC, Maor MH. Analysis of the histopathology of radiation myelopathy. Int J Radiat Oncol Biol Phys 1988; 14: 27-32.
7. Schultheiss TE et al. Radiation response of the central nervous system. Int J Radiat Oncol Biol Phys 1995; 31: 1093-1112.
8. Ésik O et al. Radiation myelopathy with partial functional recovery: PET evidence of long-term increased metabolic activity of the spinal cord. J Neurol Sci 1999; 163: 39-43.
9. Sanyal B et al. Radiation myelopathy. J Neurol Neurosurg Psychol 1979; 42: 413-418.
10. Berlit P, Schwechheimer K. Neuropathological findings in radiation myelopathy of the lumbosacral cord. Eur Neurol 1987; 27: 29-34.
11. Bowen J et al. The post-irradiation lower motor neuron syndrome. Neuronopathy or radiculopathy? Brain 1996; 119: 1429-1439.
12. de Carolis P et al. Isolated lower motoneuron involvement following radiotherapy. J Neurol Neurosurg Psychol 1986; 49: 718-719.
13. de Greve JLP et al. Lower motor neuron disease in a patient with Hodgkin's disease treated with radiotherapy. Clin Neurol Neurosurg 1984; 86: 43-46.
14. Ésik O et al. A PET study on the characterization of partially reversible radiogenic lower motor neurone disease. Spinal Cord 2002; 40: 468-473.
15. Feistner H et al. Post-irradiation lesions of the caudal roots. Acta Neurol Scand 1989; 80: 277-281.
16. Friedman M. Calculated risks of radiation injury of normal tissue in the treatment of cancer of the testis. In: Proceedings of the Second National Cancer Conference, American Cancer Society, Vol. 1. New York 1954, pp 390-400.
17. Gállego J et al. Delayed postirradiation lower motor neuron syndrome. Ann Neurol 1986; 19: 308-309.
18. Greenfield MM, Stark FM. Post-irradiation neuropathy. Am J Roentgenol 1948; 60: 617-622.
19. Grünewald RA et al. Late onset radiation-induced motor neuron syndrome. J Neurol Neurosurg Psychol 1992; 55: 741-742.
20. Horowitz SL, Stewart JD. Lower motor neuron syndrome following radiotherapy. Can J Neurol Sci 1983; 10: 56-58.
21. Katirji MB. Delayed postirradiation focal motor neuron syndrome. Muscle Nerve 1990; 13: 1185-1186.
22. Kristensen O, Melgard B, Schiødt AV. Radiation myelopathy of the lumbo-sacral spinal cord. Acta Neurol Scand 1977; 56: 217-222.
23. Lamy C et al. Postradiation lower motor neuron syndrome presenting as monomelic amyotrophy. J Neurol Neurosurg Psychol 1991; 54: 648-649.
24. Maier JG et al. Radiation myelitis of the dorsolumbar spinal cord. Radiology 1969; 93: 153-160.
25. Sadowsky CH, Sachs Jr E, Ochoa J. Postradiation motor neuron syndrome. Arch Neurol 1976; 33: 786-787.
26. Schiødt AV, Kristensen O. Neurologic complications after irradiation of malignant tumors of the testis. Acta Radiol Oncol 1978; 17: 369-378.
27. Schold SC et al. Subacute motor neuropathy: a remote effect of lymphoma. Ann Neurol 1979; 5: 271-287.
28. Tallaksen CME, Jetne V, Fosså S. Postradiation lower motor neuron syndrome. A case report and brief literature review. Acta Oncol 1997; 36: 345-347.
29. Tan SV, Pye IF. Postradiation motor neuron syndrome of the upper cervical region - a manifestation of the combined effect of cranial irradiation and intrathecal chemotherapy? J Neurol Neurosurg Psychol 1991; 54: 469-470.
30. Cohen JI. Enteroviruses and reoviruses. In: Fauci et al (eds): Harrison's: Principles of Internal Medicine, 14th edn. McGraw-Hill: New York 1998, pp 1118-1123.
31. Halstead LS, Rossi C. Post-polio syndrome: clinical experience with 132 consecutive outpatients. In: Halstead LS, Wiechers DO (eds): Research and Clinical Aspects of Late Effects of Poliomyelitis Birth Defects, March of Dimes, White Plains, NY, Original Article Series, Vol. 23. 1987, pp 13-26.
32. Sharief MK, Hentges R, Ciardi M. Intrathecal immune response in patients with post-polio syndrome. N Eng J Med 1991; 325: 749-755.
33. Wong CS, van Dyk J, Milosevic M, Laperriere NJ. Radiation myelopathy following single courses of radiotherapy and retreatment. Int J Radiat Oncol Biol Phys 1994; 30: 575-581.
34. Ang KK et al. Extent and kinetics of recovery of occult spinal cord injury. Int J Radiat Oncol Biol Phys 2001; 50: 1013-1020.
35. Miller DC. Post-polio syndrome spinal cord pathology. Case report with immunopathology. Ann NY Acad Sci 1995; 753: 186-193.
36. Ang KK et al. The tolerance of primate spinal cord to reirradiation. Int J Radiat Oncol Biol Phys 1993; 25: 459-464.
37. Abbatucci JS et al. Radiation myelopathy of the cervical spinal cord: time, dose and volume factors. Int J Radiat Oncol Biol Phys 1978; 4: 239-248.
38. Campbell AMG, Williams ER, Pearce J. Late motor neuron degeneration following poliomyelitis. Neurology 1969; 19: 1101-1106.
39. de Scisciolo G et al. Long-term nervous system damage from radiation of the spinal cord: an electrophysiological study. J Neurol 1991; 238: 9-15.
40. Snooks SJ, Swash M. Motor conduction velocity in the human spinal cord: slowed conduction in multiple sclerosis and radiation myelopathy. J Neurol Neurosurg Psychol 1985; 48: 1135-1139.
41. Dinsmore S, Dambrosia J, Dalakas MC. A double-blind, placebo-controlled trials of high-dose prednisone for the treatment of post-poliomyelitis syndrome. Ann NY Acad Sci 1995; 753: 303-313.
42. Dalakas MC. Pathogenetic mechanisms of post-polio syndrome: morphological, electrophysiological, virological, and immunological correlations. Ann NY Acad Sci 1995; 753: 167-185.
43. Julien J et al. Postpolio syndrome: poliovirus persistence is involved in the pathogenesis. J Neurol 1999; 246: 472-476.
44. Leparc-Goffart I et al. Evidence of presence of poliovirus genomic sequences in cerebrospinal fluid from patients with postpolio syndrome. J Clin Microbiol 1996; 34: 2023-2026.
45. Muir P et al. Evidence for persistent enterovirus infection of the central nervous system in patients with previous paralytic poliomyelitis. Ann NY Acad Sci 1995; 753: 219-232.
46. Recine U et al. An unusually severe subacute motor neuronopathy in Hodgkin's disease. Acta Haematol 1984; 71: 135-138.
47. Rowland LP, Schneck SA. Neuromuscular disorders associated with malignant neoplastic disease. J Chron Dis 1963; 16: 777-795.
48. Walton JN, Tomlinson BE, Pearce GN. Subacute 'poliomyelitis' and Hodgkin's disease. J Neurol Sci 1968; 6: 435-445.
49. Löffel M et al. Impfpoliomyelitis bei einem Erwachsenen unter Chemotherapie wegen Non-Hodgkin-lymphoms (Vaccine poliomyelitis in an adult undergoing chemotherapy for non-Hodgkin lymphoma). Schweiz Med Wochenschr 1982; 12: 419-421.
50. Rodriguez M, Oleszak E, Leibowitz J. Theiler's murine encephalomyelitis: a model of demyelination and persistence of virus. Crit Rev Immunol 1987; 7: 325-365.
51. Rodriguez M, Patick AK, Pease LR. Abrogation of resistance to Theiler's virus-induced demyelination in C57BL mice by total body irradiation. J Neuroimmunol 1990; 26: 189-199.
52. Murray PD et al. Diphasic and regionally-restricted chemokine expression in the central nervous system in the Theiler's virus model of multiple sclerosis. J Neurovirol 2000;(Suppl 1):S44-S52.
53. Bruno RL. Paralytic vs 'nonparalytic' polio: distinction without a difference? Am J Phys Med Rehabil 2000; 79: 4-12.