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1
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0037392220
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Off-pump coronary artery bypass grafting provides complete revascularization with reduced myocardial injury, transfusion requirements, and length of stay, a prospective randomized comparison of two hundred unselected patients undergoing off-pump versus conventional coronary artery bypass grafting
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Puskas JD, Williams WH, Duke PG, et al. Off-pump coronary artery bypass grafting provides complete revascularization with reduced myocardial injury, transfusion requirements, and length of stay, a prospective randomized comparison of two hundred unselected patients undergoing off-pump versus conventional coronary artery bypass grafting. J Thorac Cardiovasc Surg 2003; 125:797-808. An excellent clinical trial demonstrating that OPCAB results in a comparable extent of revascularization, and an improved early postoperative clinical profile compared with conventional CABG with CBP in low-risk patients.
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J Thorac Cardiovasc Surg
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A comparison of on-pump and off-pump coronary bypass surgery in low-risk patients
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Nathoe HM, van Dijk D, Jansen EW, et al. A comparison of on-pump and off-pump coronary bypass surgery in low-risk patients. N Engl J Med 2003; 348:394-402. An excellent clinical trial demonstrating that revascularization with OPCAB results in comparable exercise tolerance and one-year graft patency rates to conventional CABG with CBP in low-risk patients. This paper provides considerable reassurance regarding the quality of revascularization achieved with OPCAB.
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N Engl J Med
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Nathoe, H.M.1
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3
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Caputo M, Yeatman M, Narayan P, et al. Effect of off-pump coronary surgery with right ventricular assist device on organ function and inflammatory response: a randomized controlled trial. Ann Thorac Surg 2002; 74:2088-2095. A well-conducted clinical trial demonstrating that OPCAB attenuates the indices of organ injury and improves the early postoperative clinical profile compared with conventional CABG with CBP in low-risk patients. There was no added benefit of the use of RVADs.
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Ann Thorac Surg
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Caputo, M.1
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4
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Meyns B, Autschbach R, Boning A, et al. Coronary artery bypass grafting supported with intracardiac microaxial pumps versus normothermic cardiopulmonary bypass: a prospective randomized trial. Eur J Cardiothorac Surg 2002; 22:112-117. A good clinical trial demonstrating the feasibility and safety of OPCAB with microaxial pumps, which are safe when compared with conventional CABG with CBP in low-risk patients.
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Eur J Cardiothorac Surg
, vol.22
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Meyns, B.1
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5
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Inoue T, Ku K, Kaneda T, et al. Cardioprotective effects of lowering oxygen tension after aortic unclamping on cardiopulmonary bypass during coronary artery bypass grafting. Circ J 2002; 66:718-722. A highly original clinical trial demonstrating that reperfusion post-aortic unclamping at lower oxygen tension may have protective effects in patients undergoing CPB.
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Circ J
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Inoue, T.1
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6
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Sievers HH, Freund-Kaas C, Eleftheriadis S, et al. Lung protection during total cardiopulmonary bypass by isolated lung perfusion: preliminary results of a novel perfusion strategy. Ann Thorac Surg 2002; 74:1167-1172. An original, preliminary clinical trial demonstrating that hypothermic lung perfusion during CPB may reduce inflammation and acute lung injury in patients undergoing CPB.
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Ann Thorac Surg
, vol.74
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Sievers, H.H.1
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7
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Regional oxygenation and systemic inflammatory response during cardiopulmonary bypass: Influence of temperature and blood flow variations
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Lindholm L, Bengtsson A, Hansdottir V, et al. Regional oxygenation and systemic inflammatory response during cardiopulmonary bypass: influence of temperature and blood flow variations. J Cardiothorac Vasc Anesth 2003; 17:182-187.
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J Cardiothorac Vasc Anesth
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, pp. 182-187
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Lindholm, L.1
Bengtsson, A.2
Hansdottir, V.3
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8
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Laffey JG, Boylan JF, Cheng DC. The systemic inflammatory response to cardiac surgery: implications for the anesthesiologist. Anesthesiology 2002; 97:215-252.
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Anesthesiology
, vol.97
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Laffey, J.G.1
Boylan, J.F.2
Cheng, D.C.3
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9
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Kalawski, R.1
Majewski, M.2
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10
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Koster A, Fischer T, Praus M, et al. Hemostatic activation and inflammatory response during cardiopulmonary bypass: impact of heparin management. Anesthesiology 2002; 97:837-841. An interesting, well-conducted clinical trial demonstrating that heparin management may modulate the inflammatory response in patients undergoing CPB.
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Anesthesiology
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, pp. 837-841
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Koster, A.1
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11
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Svenmarker S, Haggmark S, Jansson E, et al. Use of heparin-bonded circuits in cardiopulmonary bypass improves clinical outcome. Scand Cardiovasc J 2002; 36:241-246. This important paper aggregates data from two previous HCC studies and demonstrates that HCCs improve short-term clinical outcome but not 5-year survival in low-risk patients undergoing CPB.
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Scand Cardiovasc J
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Svenmarker, S.1
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Duroflo II heparin bonding does not attenuate cytokine release or improve pulmonary function
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Butler J, Murithi EW, Pathi VL, et al. Duroflo II heparin bonding does not attenuate cytokine release or improve pulmonary function. Ann Thorac Surg 2002; 74:139-142.
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Ann Thorac Surg
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Butler, J.1
Murithi, E.W.2
Pathi, V.L.3
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15
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A prospective, double-blind study on the efficacy of the bioline surface-heparinized extracorporeal perfusion circuit
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Palatianos GM, Foroulis CN, Vassili MI, et al. A prospective, double-blind study on the efficacy of the bioline surface-heparinized extracorporeal perfusion circuit. Ann Thorac Surg 2003; 76:129-135. A well-conducted clinical trial demonstrating that the bioline HCC may modulate the inflammatory response and confer some clinical benefit in low-risk patients undergoing CPB.
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Ann Thorac Surg
, vol.76
, pp. 129-135
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Palatianos, G.M.1
Foroulis, C.N.2
Vassili, M.I.3
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16
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Johnell M, Elgue G, Larsson R, et al. Coagulation, fibrinolysis, and cell activation in patients and shed mediastinal blood during coronary artery bypass grafting with a new heparin-coated surface. J Thorac Cardiovasc Surg 2002; 124:321-332.
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, pp. 321-332
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Johnell, M.1
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Larsson, R.3
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17
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Jensen E, Andreasson S, Bengtsson A, et al. Influence of two different perfusion systems on inflammatory response in pediatric heart surgery. Ann Thorac Surg 2003; 5:919-925.
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Ann Thorac Surg
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Jensen, E.1
Andreasson, S.2
Bengtsson, A.3
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18
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Fromes Y, Gaillard D, Ponzio O, et al. Reduction of the inflammatory response following coronary bypass grafting with total minimal extracorporeal circulation. Eur J Cardiothorac Surg 2002; 22:527-533. An interesting, small clinical trial demonstrating that a minimized extracorporeal circuit may attenuate the inflammatory response in patients undergoing CPB.
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Eur J Cardiothorac Surg
, vol.22
, pp. 527-533
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Fromes, Y.1
Gaillard, D.2
Ponzio, O.3
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19
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Ninomiya M, Miyaji K, Takamoto S. Influence of PMEA-coated bypass circuits on perioperative inflammatory response. Ann Thorac Surg 2003; 75:913-917.
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Ann Thorac Surg
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Ninomiya, M.1
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Takamoto, S.3
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20
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Clinical performance and biocompatibility of poly(2-methoxyethylacrylate) -coated extracorporeal circuits
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Gunaydin S, Farsak B, Kocakulak M, et al. Clinical performance and biocompatibility of poly(2-methoxyethylacrylate)-coated extracorporeal circuits. Ann Thorac Surg 2002; 74:819-824. An interesting, small clinical trial demonstrating that a poly(2-methoxyethylacrylate)-coated oxygenator may attenuate the inflammatory response and confer clinical benefit in patients undergoing CPB.
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Ann Thorac Surg
, vol.74
, pp. 819-824
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Gunaydin, S.1
Farsak, B.2
Kocakulak, M.3
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21
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Dickinson T, Mahoney CB, Simmons M, et al. Trillium-coated oxygenators in adult open-heart surgery: a prospective randomized trial. J Extra-Corpor Technol 2002; 34:248-253.
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J Extra-Corpor Technol
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Dickinson, T.1
Mahoney, C.B.2
Simmons, M.3
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22
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Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgery
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Mathew JP, Grocott HP, Phillips-Bute B, et al. Lower endotoxin immunity predicts increased cognitive dysfunction in elderly patients after cardiac surgery. Stroke 2003; 34:508-513. An important clinical study demonstrating that a lowered preoperative endotoxin immunity predicts an increased risk of cognitive dysfunction post-CPB, especially among older patients.
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Stroke
, vol.34
, pp. 508-513
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Mathew, J.P.1
Grocott, H.P.2
Phillips-Bute, B.3
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23
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Endotoxemia in coronary artery bypass surgery: A comparison of the off-pump technique and conventional cardiopulmonary bypass
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Aydin NB, Gercekoglu H, Aksu B, et al. Endotoxemia in coronary artery bypass surgery: a comparison of the off-pump technique and conventional cardiopulmonary bypass. J Thorac Cardiovasc Surg 2003; 125:843-848.
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J Thorac Cardiovasc Surg
, vol.125
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Aydin, N.B.1
Gercekoglu, H.2
Aksu, B.3
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24
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0037202805
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Enterai application of an immunoglobulin-enriched colostrum milk preparation for reducing endotoxin translocation and acute phase response in patients undergoing coronary bypass surgery - A randomized placebo-controlled pilot trial
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Bolke E, Orth K, Jehle PM, et al. Enterai application of an immunoglobulin-enriched colostrum milk preparation for reducing endotoxin translocation and acute phase response in patients undergoing coronary bypass surgery - a randomized placebo-controlled pilot trial. Wien Klin Wochenschr 2002; 114:923-928.
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Wien Klin Wochenschr
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Bolke, E.1
Orth, K.2
Jehle, P.M.3
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25
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Automated detection of gastric luminal partial pressure of carbon dioxide during cardiovascular surgery using the Tonocap
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Bennett-Guerrero E, Panah MH, Bodian CA, et al. Automated detection of gastric luminal partial pressure of carbon dioxide during cardiovascular surgery using the Tonocap. Anesthesiology 2000; 92:38-45.
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Anesthesiology
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Bennett-Guerrero, E.1
Panah, M.H.2
Bodian, C.A.3
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26
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Boldt J, Brosch C, Suttner S, et al. Prophylactic use of the phosphodiesterase III inhibitor enoximone in elderly cardiac surgery patients: effect on hemodynamics, inflammation, and markers of organ function. Intens Care Med 2002; 28:1462-1469. An interesting, small clinical trial demonstrating that perioperative Enoximone therapy may attenuate the inflammatory response and confer clinical benefit in elderly patients undergoing CPB.
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Intens Care Med
, vol.28
, pp. 1462-1469
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Boldt, J.1
Brosch, C.2
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27
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Bach F, Grundmann U, Bauer M, et al. Modulation of the inflammatory response to cardiopulmonary bypass by dopexamine and epidural anesthesia. Acta Anaesthesiol Scand 2002; 46:1227-1235.
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Acta Anaesthesiol Scand
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Bach, F.1
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Torino
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Gol MK, Nisanoglu V, Iscan Z, et al. Inhibition of systemic inflammatory response with sodium nitroprusside in open heart surgery. J Cardiovasc Surg (Torino) 2002; 43:803-809.
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J Cardiovasc Surg
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Gol, M.K.1
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Fansa I, Gol M, Nisanoglu V, et al. Does diltiazem inhibit the inflammatory response in cardiopulmonary bypass? Med Sci Monit 2003; 9:P130-P136.
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Med Sci Monit
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Fansa, I.1
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30
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Effect of modified urtrafiltration on the inflammatory response in paediatric open-heart surgery: A prospective, randomized study
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Chew MS, Brix-Christensen V, Ravn HB, et al. Effect of modified urtrafiltration on the inflammatory response in paediatric open-heart surgery: a prospective, randomized study. Perfusion 2002; 17:327-333. An interesting, small clinical trial demonstrating that modified ultrafiltration may improve postoperative clinical profile but does not attenuate the inflammatory response in children undergoing CPB for congenital heart surgery.
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Perfusion
, vol.17
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Chew, M.S.1
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31
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Effect of WBC reduction of transfused RBCs on postoperative infection rates in cardiac surgery
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Wallis JP, Chapman CE, Orr KE, et al. Effect of WBC reduction of transfused RBCs on postoperative infection rates in cardiac surgery. Transfusion 2002; 42:1127-1134. An important, large-scale clinical trial demonstrating that leukocyte reduction of transfused RBCs may decrease the postoperative infection rate in low-risk patients undergoing cardiac surgery with CPB.
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Transfusion
, vol.42
, pp. 1127-1134
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Wallis, J.P.1
Chapman, C.E.2
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Leukocyte filtration fails to limit functional neutrophil activity during cardiac surgery
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Scholz M, Simon A, Matheis G, et al. Leukocyte filtration fails to limit functional neutrophil activity during cardiac surgery. Inflamm Res 2002; 51:363-368.
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Inflamm Res
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Simon, A.2
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Fattorutto M, Pradier O, Jansens JL, et al. Plateletpheresis the day before cardiac surgery and the impairment of platelet function. Eur J Anaesthesiol 2003; 20:338-340.
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Eur J Anaesthesiol
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Levi, M.1
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Does aprotinin influence the inflammatory response to cardiopulmonary bypass in patients?
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Schmartz D, Tabardel Y, Preiser JC, et al. Does aprotinin influence the inflammatory response to cardiopulmonary bypass in patients? J Thorac Cardiovasc Surg 2003; 125:184-190.
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J Thorac Cardiovasc Surg
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Schmartz, D.1
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High-dose aprotinin reduces activation of hemostasis, allogeneic blood requirement, and duration of postoperative ventilation in pediatric cardiac surgery
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Mossinger H, Dietrich W, Braun SL, et al. High-dose aprotinin reduces activation of hemostasis, allogeneic blood requirement, and duration of postoperative ventilation in pediatric cardiac surgery. Ann Thorac Surg 2003; 75:430-437. A well-conducted, small clinical trial demonstrating that aprotinin improves the postoperative clinical profile but has limited anti-inflammatory activity in children undergoing CPB for congenital heart surgery.
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Ann Thorac Surg
, vol.75
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Mossinger, H.1
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Aprotinin mediated antioxidant effect in cardiosurgery with mechanical cardiorespiratory support (CMCS)
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Broche F, Romero A, Olembe E, et al. Aprotinin mediated antioxidant effect in cardiosurgery with mechanical cardiorespiratory support (CMCS). J Cardiovasc Surg (Torino) 2002; 43:429-436. A small non-randomized clinical trial demonstrating that aprotinin inhibits free radical generation in high-risk children undergoing CPB for congenital heart surgery.
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J Cardiovasc Surg
, vol.43
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Broche, F.1
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Julier K, da Silva R, Garcia C, et al. Preconditioning by sevoflurane decreases biochemical markers for myocardial and renal dysfunction in coronary artery bypass graft surgery: a double-blinded, placebo-controlled, multicenter study. Anesthesiology 2003; 98:1315-1327. An interesting clinical trial demonstrating that pharmacological preconditioning with sevoflurane may attenuate myocardial and renal dysfunction in low-risk patients undergoing cardiac surgery with CPB.
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Anesthesiology
, vol.98
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Julier, K.1
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Anesthesiology
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De Hert, S.G.1
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Zilberstein G, Levy R, Rachinsky M, et al. Ketamine attenuates neutrophil activation after cardiopulmonary bypass. Anesth Analg 2002; 95:531-536.
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Anesth Analg
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Koster A, Chew DP, Kuebler W, et al. Effects of tirofiban on hemostatic activation and inflammatory response during cardiopulmonary bypass. Am J Cardiol 2003; 91:346-347. An interesting preliminary clinical trial demonstrating that tirofiban attenuates haemostatic dysfunction and inflammation in low-risk patients undergoing cardiac surgery with CPB.
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Am J Cardiol
, vol.91
, pp. 346-347
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Koster, A.1
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Br J Anaesth
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Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery
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Kilger E, Weis F, Briegel J, et al. Stress doses of hydrocortisone reduce severe systemic inflammatory response syndrome and improve early outcome in a risk group of patients after cardiac surgery. Crit Care Med 2003; 31:1068-1074. An important, well-conducted, clinical trial demonstrating that hydrocortisone attenuates the inflammatory response and improves the postoperative clinical profile in high-risk patients undergoing cardiac surgery with CPB.
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Crit Care Med
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Kilger, E.1
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