Endocrinological Effects of High-Dose Hypericum perforatum Extract WS 5570 in Healthy Subjects

Neuropsychobiology

Volumn 49, Issue 2, 2004, Pages 58-63

  Schule C ^a   Baghai, T ^a   Sauer, N ^a   Laakmann, G ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Adrenocorticotropic hormone; Cortisol; Growth hormone; Hyperforin; Prolactin; St. John's wort (Hypericum perforatum) extract WS 5570

Indexed keywords

CORTICOTROPIN; GROWTH HORMONE; HYDROCORTISONE; HYPERICUM PERFORATUM EXTRACT; PLACEBO; PROLACTIN;

ADULT; ANALYSIS OF VARIANCE; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CHEMOLUMINESCENCE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORTICOTROPIN RELEASE; DOUBLE ANTIBODY SANDWICH ENZYME LINKED IMMUNOSORBENT ASSAY; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG MEGADOSE; FLUOROIMMUNOASSAY; GROWTH HORMONE RELEASE; HEART RATE VARIABILITY; HORMONAL REGULATION; HUMAN; HYDROCORTISONE RELEASE; HYPERICUM PERFORATUM; INTRAVENOUS CATHETER; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; PRIORITY JOURNAL; PROLACTIN RELEASE; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE;

ADRENOCORTICOTROPIC HORMONE; ADULT; ANALYSIS OF VARIANCE; BLOOD PRESSURE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE GLANDS; GROWTH HORMONE; HEART RATE; HUMANS; HYDROCORTISONE; HYPERICUM; MALE; NEUROSECRETORY SYSTEMS; PLANT EXTRACTS; PROLACTIN; RADIOIMMUNOASSAY; SINGLE-BLIND METHOD; TIME FACTORS;

EID: 1342333620     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000076411     Document Type: Article

References (19)

1. Linde K, Ramirez G, Mulrow CD, Pauls A, Weidenhammer W, Melchart D: St. John's wort for depression - an overview and metaanalysis of randomised clinical trials. BMJ 1996;313:253-258.
2. Laakmann G, Jahn G, Schüle C: Hypericum perforatum extract in treatment of mild to moderate depression: Clinical and pharmacological aspects. Nervenarzt 2002;73:600-612.
3. Suzuki O, Katsumata Y, Oya M, Bladt S, Wagner H: Inhibition of monoamine oxidase by hypericin. Planta Med 1984;50:272-274.
4. Müller WE, Rolli M, Schäfer C, Hafner U: Effects of hypericum extract (LI 160) in biochemical models of antidepressant activity. Pharmacopsychiatry 1997;30(suppl 2):102-107.
5. Müller WE, Singer A, Wonnemann M, Hafner U, Rolli M, Schäfer C: Hyperforin represents the neurotransmitter reuptake inhibiting constituent of hypericum extract. Pharmacopsychiatry 1998;31(suppl 1):16-21.
6. 3H-GABA by hyperforin, a major constituent of St. John's wort: The role of amiloride sensitive sodium conductive pathways. Neuropsychopharmacology 2000;23:188-197.
7. Müller WE: Current St. John's wort research from mode of action to clinical efficacy. Pharmacol Res 2003;47:101-109.
8. Laakmann G, Schüle C, Baghai T, Kieser M: St. John's wort in mild to moderate depression: The relevance of hyperforin for the clinical efficacy. Pharmacopsychiatry 1998;31(suppl 1):54-59.
9. Schüle C, Baghai T, Ferrera A, Laakmann G: Neuroendocrine effects of Hypericum extract WS 5570 in 12 healthy male volunteers. Pharmacopsychiatry 2001;34(suppl 1):127-133.
10. Tuomisto J, Mannisto P: Neurotransmitter regulation of anterior pituitary hormones. Pharmacol Rev 1985;37:249-332.
11. Laakmann G: Psychopharmaco-endocrinology and depression research. Monogr Gesamtgeb Psychiatr Psychiatry Ser 1988;46:1-220.
12. Franklin M, Chi J, McGavin C, Hockney R, Reed A, Campling G, Whale RW, Cowen PJ: Neuroendocrine evidence for dopaminergic actions of Hypericum extract (LI 160) in healthy volunteers. Biol Psychiatry 1999;46:581-584.
13. World Medical Association: World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. Ferney-Voltaire, World Medical Association, 2000. http://www.wma.net/e/policy/ b3.htm
14. Friedman B: Principles and Techniques of Applied Mathematics. New York, Wiley & Sons, 1956.
15. Al-Damluji S: Adrenergic control of the secretion of anterior pituitary hormones. Baillières Clin Endocrinol Metab 1993;7:355-392.
16. Franklin M, McGavin C, Reed A, Cowen PF: Effect of Hypericum perforatum on salivary cortisol in healthy male volunteers. J Psychopharmacol 1999;30(suppl 2):A16.
17. Biber A, Fischer H, Romer A, Chatterjee SS: Oral bioavailability of hyperforin from hypericum extracts in rats and human volunteers. Pharmacopsychiatry 1998;31(suppl 1):36-43.
18. Leong DA, Frawley LS, Neill JD: Neuroendocrine control of prolactin secretion. Annu Rev Physiol 1983;45:109-127.
19. Brockmöller J, Reum T, Bauer S, Kerb R, Hübner WD, Roots I: Hypericin and pseudohypericin: Pharmacokinetics and effects on photosensitivity in humans. Pharmacopsychiatry 1997;30(suppl 2):94-101.