Evaluation of time-resolved autofluorescence images of the ocular fundus

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 5141, Issue , 2003, Pages 8-17

  Schweitzer, Dietrich ^a   Hammer, Martin ^a   Schweitzer, Frank ^a   Schenke, Stefan ^a   Gaillard, Elizabeth R ^b  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b NORTHERN ILLINOIS UNIVERSITY   (United States)

Author keywords

Advanced glycation end product; Age related macular degeneration; FAD; Fluorescence; Laser scanning ophthalmoscope; Lifetime; Lipofuscin; NADH; Ocular fundus

Indexed keywords

BIOLOGICAL ORGANS; CELLS; DISEASES; FLUORESCENCE; LASER APPLICATIONS; METABOLISM; OPHTHALMOLOGY; OPTICAL RESOLVING POWER; SPECTRUM ANALYSIS;

ADVANCED GLYCATION END PRODUCT; AGE RELATED MACULAR DEGENERATION; LASER SCANNING OPHTHALMOSCOPE; LIPOFUSCIN; OCULAR FUNDUS; TIME RESOLVED AUTOFLUORESCENCE;

MEDICAL IMAGING;

EID: 1342331819     PISSN: 0277786X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.499641     Document Type: Conference Paper

References (15)

1. Chance B "Pyridine nucleotide as an indicator of the oxygen requirements for energy-linked functions of mitochondrua". Circ. Res. May; 38(5 Suppl 1): 131-8, 1976
2. Anderson-Engels A, Gustafson A, Johannson J, Stenram U, Svanberg K, Svanberg S "Investigation of Possible Fluorophores in Human Atherosclerotic Plaque" Laser in Life Science 5 (1-2): 1-11, 1992
3. Lakowicz, J. R. "Principles of Fluorescence Spectroscopy" Kluwer Academic/Plenum Publishers: New York, Boston, Dondrecht, London, Moscow, 1999.
4. American National Standard for Use of Lasers ANSI Z 136.1-2000 (2000) Laser Institute of America, Suite 128, 13501 Ingenuite Drive, Orlando, FL 32826
5. Schweitzer D, Kolb A, Hammer M, Thamm E "Basic investigations for 2-dimensional time resolved fluorescence measuremetns at the fundus" International Ophthalmology 23:4-6:399-404, 2001.
6. Schweitzer D, Kolb A, Hammer M, Thamm E "Tau mapping of the autofluorescence of the human ocular fundus" Progress in biomedical optics and imaging, Vol. 1 No. 35 ISSN 1605-7422, Proceedings of SPIE, Vol. 4164, pp. 79-89.
7. Schweitzer D, Kolb A, Hammer M "Autofluorescence lifetime measurements in images of the human ocular fundus" Progress in biomedical optics and imaging, Vol. 2 No. 32 ISSN 1605-7422, Proceedings of SPIE, Vol. 4432, pp. 29-39
8. Schweitzer D, Kolb A, Hammer M Anders R "Zeitaufgelöste Messung der Autofluoreszenz- ein Werkzeug zur Erfassung von Stoffwechselvorgängen am Augenhintergrund" Ophthalmologe 2002, Vol. 99, pp. 776-779
9. Voss K, Ortmann W, Suesse H "Bildmatching und Bewegungskompensation bei Fundus-Bildern" Proc. 20.DAGM-Symposium, Stuttgart 1998, "Musterekennung 1998", Springer 1998, 439-446, also available under http://pandora.inf.uni-jena.de/papers/fundus/fundus.html
10. Eldred GE, Katz MR "Fluorophores of the Human Retinal Pigment Epithelium: Separation and Spectral Characterisation" Exp. Eye Res. 47, 71-86, 1988
11. Sakai N, Decatur J, Nakanishi K, Eldred GE "Ocular Age Pigment A2E: An Unprecendented Pyridinium Bisretinoid" J. Am. Chem. Soc. 118, 1559-1560, 1996
12. Eldred GE, Lasky MR "Retinal age pigments generated by self-assembling lysosomotropic detergents" Nature Vol. 361, 25 Feb. 724-726, 1993
13. Parish, C. A., Hashimoto, M., Nakanishi, K., Dillon, J., Sparrow, J. Isolation and one step preparation of A2E and iso A2E fluorophores from human retinal pigment epithelium. Proc Natl Acad Sci USA 95, 14609-14613, 1998
14. Gaillard ER, Atherton SJ, Eldred GE, Dillon J "Photophysical Studies on Human Retinal Lipofuscin" Photochem. Photobiol. 61, 448-453, 1995
15. Cringle, St. J., Yu, D. Y., Yu, P. K., Su, E. N. "Intraretinal Oxygen Consumption in Rat in Vivo" Invest Ophthalmol Vis Sci 43, 6, 1922-1927, 2002