Identification of principal cytochrome P-450 in triphenyltin metabolism in rats

Toxicology Letters

Volumn 148, Issue 1-2, 2004, Pages 141-148

  Ohhira, Shuji ^a   Watanabe, Masatomo ^a   Matsui, Hisao ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Hepatic cytochrome P 4502C6; Metabolism; Rat; Triphenyltin

Indexed keywords

CIMETIDINE; COMPLEMENTARY DNA; CYTOCHROME P450; CYTOCHROME P450 2B1; CYTOCHROME P450 2C; TRIPHENYLTIN CHLORIDE;

ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DEARYLATION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; MALE; METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SEX DIFFERENCE; STATISTICAL SIGNIFICANCE;

EID: 1342328040     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2004.01.002     Document Type: Article

References (25)

1. Blunden, S.J., Evans, C.J., 1990. Organotin compounds. In: Hutzinger, O. (Ed.), The Handbook of Environmental Chemistry, vol. 3: Anthropogenic Compounds. Springer-Verlag, New York, pp. 1-44 (Part E).
2. Chang T., Levine M., Bellward G.D. Selective inhibition of rat hepatic microsomal cytochrome P-450. Part II. Effect of the in vitro administration of cimetidine. J. Pharmacol. Exp. Ther. 260:1992;1450-1455.
3. Chao J.S., Wei L.Y., Huang M.C., Liang S.C., Chen H.H. Genotoxic effects of triphenyltin acetate and triphenyltin hydroxide on mammalian cells in vitro and in vivo. Mutat. Res. 444:1999;167-174.
4. Cima, F., Craig, P.J., Harrington, C., 2003. Organotin compounds in the environment. In: Craig, P.J. (Ed.), Organometallic Compounds in the Environment, second ed. Wiley, West Sussex, pp. 101-149.
5. Crespi C.L., Penman B.W. Use of cDNA-expressed human cytochrome P450 enzymes to study potential drug-drug interactions. Adv. Pharmacol. 43:1997;171-188.
6. Funae, Y., Imaoka, S., 1993. Cytochrome P450 in rodents. In: Schenkman, J.B., Greim, H. (Eds.), Cytochrome P450. Handbook of Experimental Pharmacy, vol. 105. Springer-Verlag, Berlin, Heidelberg, pp. 221-238.
7. Guengerich F.P. Cytochrome-P450 enzymes. Am. Sci. 81:1993;440-447.
8. Hogeboom, G.H., 1955. Fractionation of cell components of animal tissues. In: Colowick, S.P., Kaplan, N.O. (Eds.), Methods in Enzymology, vol. 1. Academic Press, New York, pp. 16-19.
9. Horiguchi T., Hyeon-Seo C., Shiraishi H., Shibata Y., Soma M., Morita M., Shimizu M. Field studies on imposex and organotin accumulation in the rock shell, Thais clavigera, from the Seto Inland Sea and Sanriku region, Japan. Sci. Total Environ. 214:1998;65-70.
10. Kaminsky L.S., de Morais S.M.F., Faletto M.B., Dunbar D.A., Goldstein J.A. Correlation of human cytochrome P4502C substrate specificities with primary structure: warfarin as a probe. Mol. Pharmacol. 43:1993;234-239.
11. Kang J.J., Chen I.L., Cheng Y.W. Induction of calcium release from isolated sarcoplasmic reticulum by triphenyltin. J. Biochem. 122:1997;173-177.
12. Lang D., Bocker R. Highly sensitive and specific high-performance liquid chromatographic analysis of 7-hydroxywarfarin, a marker for human cytochrome P-4502C9 activity. J. Chromatogr. 672:1995;305-309.
13. Levin M., Law E.Y.W., Bandiera S.M., Chang T.K.H., Bellward G.D. In vivo cimetidine inhibits hepatic CYP2C6 and CYP2C11 but not CYP1A1 in adult male rats. J. Pharmacol. Exp. Ther. 284:1998;493-499.
14. Lewis, D.F.V., 1996. P450 substrate specificity and metabolism. Induction, regulation and inhibition. Structural models of P450s and related topics. In: Rubinstein, M.H., Wilson, C.G. (Eds.), Cytochromes P450 Structure, Function and Mechanism. The Taylor & Francis Series in Pharmaceutical Sciences, Taylor & Francis, London, pp. 115-291.
15. Lo S.A.A., Albers P., Heimbrecht J., Jantzen E., Klingmuller D., Steckelbroeck S. Dithioerythritol (DTE) prevents inhibitory effects of triphenyltin (TPT) on the key enzymes of the human sex steroid hormone metabolism. J. Steroid Biochem. Mol. Biol. 84:2003;569-576.
16. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
17. Murray M., Reidy F. Selectivity in the inhibition of mammalian cytochromes P-450 by chemical agents. Pharmacol. Rev. 42:1990;85-101.
18. Ohhira S., Matsui H. Simultaneous determination of triphenyltin and its metabolites, mono- and diphenyltin, in biological materials by capillary gas chromatography. Bull. Environ. Contam. Toxicol. 44:1990;294-301.
19. Ohhira S., Matsui H. Comparative study of the metabolism of triphenyltin in hamsters and rats after a single oral treatment with triphenyltin chloride. Toxicol. Lett. 85:1996;3-8.
20. Ohhira S., Matsui H., Watanabe K. Effects of pretreatment with cytochrome P-450 inducers, especially phenobarbital on triphenyltin metabolism and toxicity in hamsters. Toxicology. 137:1999;151-159.
21. Ohhira S., Matsui H., Watanabe K. Effects of pretreatment with SKF-525A on triphenyltin metabolism and toxicity in mice. Toxicol. Lett. 117:2000;145-150.
22. Ohhira S., Watanabe M., Matsui H. Metabolism of tributyltin and triphenyltin by rat, hamster and human hepatic microsomes. Arch. Toxicol. 77:2003;138-144.
23. Rosenberg D.W., Sardana M.K., Kappas A. Altered induction response of hepatic cytochrome P-450 to phenobarbital, 3-methylcholanthrene, and β-naphthoflavone in organotin-treated animals. Biochem. Pharmacol. 34:1985;997-1005.
24. Saitoh M., Yanase T., Morinaga H., Tanabe M., Mu Y.M., Nishi Y., Nomura M., Okabe T., Goto K., Takayanagi R., Nawata H. Tributyltin or triphenyltin inhibits aromatase activity in the human granulose-like tumor cell line KGN. Biochem. Biophys. Res. Commun. 289:2001;198-204.
25. Trager W.F. Stereochemistry of cytochrome P-450 reactions. Drug Metab. Rev. 20:1989;489-496.