The Selective Estrogen Receptor Modulator 4-Hydroxy Tamoxifen Induces G1 Arrest and Apoptosis of Multiple Myeloma Cell Lines

Annals of the New York Academy of Sciences

Volumn 1010, Issue , 2003, Pages 321-325

  Gauduchon, Juliette ^a   Gouilleux, Fabrice ^b   Maillard, Sébastien ^c   Marsaud, Véronique ^c   Renoir, Michel J ^c   Sola, Brigitte ^a,d  

^a UNIVERSITÉ DE CAEN   (France)

^b UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^c UNIV PARIS SUD   (France)

^d CHU CÔTE DE NACRE   (France)

Author keywords

Apoptosis; Bcl 2 family; Cell cycle; Multiple myeloma; p53; Survival pathway

Indexed keywords

4 HYDROXYTAMOXIFEN; APOPTOSIS INDUCING FACTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; JANUS KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL X; PROTEIN KINASE B; STAT PROTEIN;

APOPTOSIS; CELL CYCLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CONFERENCE PAPER; CONTROLLED STUDY; HEMATOLOGIC MALIGNANCY; HUMAN; HUMAN CELL; MULTIPLE MYELOMA; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

JANUS;

EID: 1342326772     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1299.057     Document Type: Conference Paper

References (5)

1. HALLEK, M., P.L. BERGSAGEL & K.C. ANDERSON. 1998. Multiple myeloma: increasing evidence for a multistep transformation process. Blood 91: 3-21.
2. HIDESHIMA, T. & K.C. ANDERSON. 2002. Molecular mechanisms of novel therapeutic approaches for multiple myeloma. Nat. Rev. Cancer 2: 927-937.
3. TREON, S.P., G. TEOH, M. URASHIMA et al. 1998. Anti-estrogens induce apoptosis of multiple myeloma cells. Blood 92: 1749-1757.
4. OTSUKI, T., O. YAMADA, J. KUREBAYASHI et al. 2000. Estrogen receptors in myeloma cells. Cancer Res. 60: 1434-1441.
5. TROUSSARD, X., H. AVET-LOISEAU, M. MACRO et al. 2000. Cyclin D1 expression in patients with multiple myeloma. Hematol. J. 1: 181-185.