Evaluation of the carcinogenic effects of furazolidone and its metabolites in two fish species

Pharmacogenomics Journal

Volumn 4, Issue 1, 2004, Pages 24-28

  Auro, A ^a   Sumano, H ^a   Ocampo, L ^a   Barragan A ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

3 amine 2 oxazolidone; Furazolidone; Mollies; Tilapia; Tumors

Indexed keywords

3 AMINE 2 OXAZOLIDONE; DRUG METABOLITE; FURAZOLIDONE; N (5 AMINE 2 FURFURYLIDEN) 3 AMINE 2 OXAZOLIDONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMASS; BREEDING; CONTROLLED STUDY; DRUG CARCINOGENICITY; DRUG MIXTURE; FEMALE; FISH; FOOD CONTAMINATION; HISTIOCYTE; HISTOPATHOLOGY; LABORATORY TEST; LIVER TUMOR; MALE; MEAL; MELANOCYTE; NONHUMAN; PRIORITY JOURNAL; PROGENY; QUANTITATIVE ANALYSIS; SPECIES; STIMULATION; SURVIVAL; TILAPIA;

ANIMALS; CARCINOGENICITY TESTS; DRUG EVALUATION, PRECLINICAL; FEMALE; FURAZOLIDONE; KIDNEY NEOPLASMS; LIVER NEOPLASMS; MALE; POECILIA; PREGNANCY; SPECIES SPECIFICITY; TILAPIA;

ANIMALIA; AVES; MAMMALIA; OREOCHROMIS; OREOCHROMIS NILOTICUS; POECILIA; POECILIA FORMOSA; POECILIA SPHENOPS; TILAPIA;

EID: 1342310899     PISSN: 1470269X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.tpj.6500216     Document Type: Article

References (23)

1. Morris JE, Price JM, Lalich JJ, Stein RJ. The carcinogenic activity of some S-nitrofuran derivatives in the rat. Cancer Res 1969; 29: 2145-2156.
2. Ali BH. Pharmacological, therapeutic and toxicological properties of furazolidone: some recent research. Vet Res Commun 1999; 23: 343-360.
3. Hernandez-Jauregui P, Revilla-Monsalve C, Velasco-Monterrubio E. Effects of furazolidone treatment on the morphology of rooster testicle. Light and electron microscopy study. Arch Investig Med 1983; 14: 1-8.
4. Salmon RJ, Buisson JP, Zafrani B, Aussepe L, Royer R. Carcinogenic effect of 7-methoxy-2-nitro-naphtho [2, 1-b] furan (R 7000) in the forestomach of rats. Carcinogenesis 1986; 7: 1447-1450.
5. Tatsumi K, Takahashi Y. Metabolic fate of furazolidone in rats. Chem Pharm Bull Tokyo 1982; 30: 3435-3438.
6. Tatsumi K, Yamada H, Yoshimura H, Kawazoe Y. Metabolism of furazolidone by milk xanthine oxidase and rat liver 9000 g supernatant: formation of a unique nitrofuran metabolite and an aminofuran derivative. Arch Biochem Biophys 1981; 208: 167-174.
7. Stegeman JJ, Woodin BR, Singh H, Oleksiak MF, Celander M. Cytochromes P450 (CYP) in tropical fishes: catalytic activities, expression of multiple CYP proteins and high levels of microsomal P450 in liver of fishes from Bermuda. Comp Biochem Physiol Part C Pharmacol Toxicol Endocrinol 1997; 116: 61-75.
8. Bolis CL, Piccolella M, Dalla-Valle AZ, Rankin JC. Fish as model in pharmacological and biological research. Pharmacol Res 2001; 44: 265-280.
9. Woodhead AD, Setlow RB, Pond V. The amazon molly Poecilia formoza, as a test animal in carcinogenicity studies chronic exposure to physical agents. Natl Cancer Inst Monogr 1984; 65: 45-52.
10. Schartl A, Hornung U, Nanda I, Wacker R, Muller-Hermelink HK, Schlupp I et al. Susceptibility to the development of pigment cell tumors in a clone of the Amazon molly, Poecilia formoso, introduced through a microchromosome. Cancer Res 1997; 57: 2993-3000.
11. Bunton TE. Experimental chemical carcinogenesis in fish. Toxicol Pathol 1996; 24: 603-618.
12. Law JM. Issues related to the use of fish models in toxicology pathology: session introduction. Toxicol Pothol 2003: 49-52.
13. Scharti M, Schlupp I, Scharti A, Meyer MK, Nanda I, Schmid M et al. On the stability of dispensable constituents of the eukaryotic genome: stability of coding sequences versus truly hypervariable sequences in clonal vertebrate, the amazon molly, Poecilia formosa. Proc Natl Acad Sci USA 1991; 88: 8759-8763.
14. Zimmerer EJ. Usefulness of the guppy, Poecilia reticulata, in carcinogenicity testing: special advantages and problems. Natl Cancer Inst Monogr 1984; 65: 59-64.
15. Simon K, Lapis K. Carcinogenesis studies on guppies. Natl Cancer Inst Monogr 1984; 65: 71-81.
16. Conneely A, Nurgent A, O'Keeffe M. Use of solid phase extraction for the isolation and clean-up of derived furazolidone metabolite from animal tissues. Analyst 2002; 127: 705-709.
17. Pal AK, Rahman MS, Chatterjee SN. On the induction of umu gene expression in Salmonella typhimurium strain TA1535/pSK1002 by some nitrofurans. Mutat Res 1992; 280: 67-71.
18. Gajewska J, Szczypka M, Tudek B, Szymczyk T. Studies on the effect of ascorbic acid and selenium on the genotoxicity of nitrofurans: nitrofurazone and furazolidone. Mutat Res 1990; 232: 191-197.
19. Hoogenboom LAP, Berghmans MCJ, Polman THG, Parker R, Shaw IC. Depletion of protein-bound furazolidone metabolites containing the 3-amino-2-oxazolidinone side-chain from liver, kidney and muscle tissues from pigs. In: Gilbert J. and Phillips T. Food Additives & Contaminants, Vol 9 Taylor & Francis: London 1992; pp 623-630.
20. Vroomen LH, Berghmans MC, Hekman P, Hoogenboom LA, Kuiper HA. The elimination of furazolidone and its open-chain cyano-derivative from adult swine. Xenobiotica 1987; 17: 1427-1435.
21. Klee S, Baumung I, Kluge K, Ungemach FR, Horne E, O'Keeffe M et al. A contribution to safety assessment of veterinary drug residues: in vitro/ex vivo studies on the intestinal toxicity and transport of covalently bound residues. Xenobiotica 1999; 29: 641-654.
22. Hepher B Nutrición de peces comerciales en estanques. Limusa: México City 1998.
23. Ferguson HW Systemic Pathology of Fish. Iowa State University Press: Ames Iowa 1995.