Genetic deficiency of CD 16, the low-affinity receptor for immunoglobulin G, has no impact on the functional capacity of polymorphonuclear neutrophils

European Journal of Clinical Investigation

Volumn 34, Issue 2, 2004, Pages 149-155

  Wagner, C ^a   Hansch G M ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

CD16; Deficiency; Immune deficiency; Phagocytosis; Superoxide production

Indexed keywords

CD16 ANTIGEN; IMMUNOGLOBULIN G; MESSENGER RNA; SUPEROXIDE; FC RECEPTOR;

ADULT; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; BACTERIUM; CELL SURFACE; CONTROLLED STUDY; CYTOFLUOROMETRY; FEMALE; GENETIC DISORDER; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; LASER MICROSCOPY; MALE; MONOCYTE; NATURAL KILLER CELL; NEUTROPHIL; OPSONIZATION; PHAGOCYTOSIS; PRIORITY JOURNAL; RECEPTOR AFFINITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; BLOOD; CONFOCAL MICROSCOPY; GENETICS; IMMUNOLOGY; METABOLISM;

ADULT; FEMALE; HUMANS; IMMUNOGLOBULIN G; KILLER CELLS, NATURAL; MALE; MICROSCOPY, CONFOCAL; MONOCYTES; NEUTROPHILS; PHAGOCYTOSIS; RECEPTORS, IGG; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUPEROXIDES;

EID: 1342309981     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2362.2004.01298.x     Document Type: Article

References (13)

1. van den Winkel JGI, Anderson CL. Biology of human immunoglobulin G Fc receptors. J Leukoc Biol 1991;49:511-24.
2. Raghavan M, Bjorkman PJ. Fc receptors and their interactions with immunoglobulins. Annu Rev Cell Dev Biol 1996;12:181-220.
3. Morcos M, Hänsch GM, Schönermark M, Ellwanger S, Härle M, Heckl-Östreicher B. Human glomerular mesangial cells express CD16 and may be stimulated via this receptor. Kidney Int 1994;46:1627-34.
4. Dransfield I, Buckle AM, Savill JS, McDowall A, Haslett C, Hogg N. Neutrophil apoptosis is associated with a reduction of CD16 (FcgammaRIII) expression. J Immunol 1994;153:1254-63.
5. Homburg CHE, de Haas M, Verhoeven AJ, Reutlingsperger CPM, Roos D. Human neutrophils lose their surface FcgammaRIII and acquire Annexin V binding site during apoptosis in vitro. Blood 1995;85:532-40.
6. van der Schoot CE, Huizinga TW, van-t' Veer-Korthof ET, Wijmans R, von dem Borne AE. Deficiency of glycosylphospatidylinositol-linked membrane glycoproteins of leukocytes in paroxysmal nocturnal hemoglobinuria, description of a new diagnostic cytofluorometric assay. Blood 1990;76:1853-9.
7. Huizinga TW, Kuipers RW, Kleijer M, Schulpen TW, Cuypers HT, Ross D et al. Maternal genomic neutrophil FcRIII deficiency leading to neonatal isoimmune neutropenia. Blood 1990;76:1927-32.
8. Stroncek DF, Skubitz KM, Plachta LB, Shankar RA, Clay ME, Herman J et al. Alloimmune neonatal neutropenia due to neutrophil Fc gamma receptor III with maternal deficiency of CD16 antigen. Blood 1991;77:1572-80.
9. Fromont P, Bettaieb A, Skouri H, Floch C, Poulet E, Diedari N et al. Frequency of the polymorphonuclear neutrophil Fc gamma receptor III deficiency in the French population and its involvement in the development of neonatal alloimmune neutropenia. Blood 1992;79:2131-41.
10. Flesch BK, Achtert G, Bauer F, Neppert J. The NA'null' phenotype of a young man is caused by a FcγRIIIB gene deficiency while the products of the neighboring FcγRIIA and FcγRIIIA genes are present. Ann Hematol 1998;76:215-20.
11. Peltz GA, Grundy HO, Lebo RV, Yssel H, Barsh GS, Moore KW. Cloning, expression and identification of the chromosomal locus of two receptors for IgG (CD16). Proc Natl Acad Sci USA 1988;86:1013-7.
12. Ravetch JV, Perussia B. Alternative membrane forms of Fcgamma RIII (CD16) on human natural killer cells and neutrophils. Cell type specific expression of two genes that differ in a single nucleotide substitution. J Exp Med 1989;170:481-97.
13. Wagner C, Deppisch R, Denefleh B, Hug F, Andrassy K, Hänsch GM. Expression patterns of the lipopolysaccharide receptor CD14, and the Fcγ receptors CD16 and CD64 on polymorphonuclear neutrophils: data from patients with severe infections and lipopolysaccharide-exposed cells. Shock 2003;19:5-12.