Computer-assisted visualization and quantitation of experimental gastric lesions in rats

Journal of Pharmacological and Toxicological Methods

Volumn 49, Issue 2, 2004, Pages 89-95

  Khan, Haseeb Ahmad ^a  

^a The General Directorate of Armed Forces Health Services   (Saudi Arabia)

Author keywords

Computer application; Gastric ulcers; Imaging; Methods; Morphology; Quantitation; Rat; Scanning; Visualization

Indexed keywords

ALCOHOL; INDOMETACIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOMATION; COMPUTER ASSISTED DIAGNOSIS; CORRELATION ANALYSIS; DENSITY; IMAGE ANALYSIS; MALE; MORPHOLOGY; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; STOMACH LESION; STOMACH MUCOSA;

RATTUS NORVEGICUS;

EID: 1342306883     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2003.10.004     Document Type: Article

References (28)

1. Al Moutaery A.R., Tariq M. Effect of quinacrine, a phospholipase A2 inhibitor on stress and chemically induced gastroduodenal ulcers. Digestion. 58:1997;129-137.
2. Arroyo M.T., Lanas A., Sainz R. Prevention and healing of experimental indomethacin-induced gastric lesions: effects of ebrotidine, omeprazole and ranitidine. European Journal of Gastroenterology and Hepatology. 12:2000;313-318.
3. Bhargava K.P., Gupta M.B., Tangri K.K. Mechanism of ulcerogenic activity of indomethacin and ocyphenbutazone. European Journal of Pharmacology. 22:1973;191-195.
4. Joseph R.M., Varela V., Kanji V.K., Subramony C., Mihas A.A. Protective effects of zinc in indomethacin-induced gastric mucosal injury: evidence for a dual mechanism involving lipid peroxidation and nitric oxide. Alimentary Pharmacology and Therapy. 13:1999;203-208.
5. Lee M., Aldred K., Lee E., Feldman M. Aspirin-induced acute gastric mucosal injury is a neutrophil-dependent process in rats. American Journal of Physiology. 263:1992;G920-G926.
6. Liu W., Okajima K., Murakami K., Harada N., Isobe H., Irie T. Role of neutrophil elastase in stress-induced gastric mucosal injury in rats. Journal of Laboratory and Clinical Medicine. 132:1998;432-439.
7. Naito Y., Yoshikawa T., Matsuyama K., Yagi N., Arai M., Nakamura Y., Kaneko T., Yoshida N., Kondo M. Neutrophils, lipid peroxidation, and nitric oxide in gastric reperfusion injury in rats. Free Radicals in Biology and Medicine. 24:1998;494-502.
8. Natale G., Lazzeri G., Blandizzi C., Gherardi G., Lenzi P., Pellegrini A., Del Tacca M. Seriate histomorphometry of whole rat stomach: an accurate and reliable method for quantitative analysis of mucosal damage. Toxicology and Applied Pharmacology. 174:2001;17-26.
9. Parmar N.S., Desai J.K. A review of the current methodology for the evaluation of gastric and duodenal anti-ulcer agents. Indian Journal of Pharmacology. 25:1993;120-135.
10. Rainsford K.D. Quantitation by computerized visual image analysis of gastric mucosal lesions induced in mice and rats by non-steroidal anti-inflammatory drugs. Acta Physiologica Hungaria. 73:1989;371-378.
11. Santucci L., Fiorucci S., Di Matteo F.M., Morelli A. Role of tumor necrosis factor α release and leukocyte margination in indomethacin-induced gastric injury in rats. Gastroenterology. 108:1995;393-401.
12. Schiantarelli P., Cadel S., Folco G.C. Gastroprotective effects of morniflumate, an esterified anti-inflammatory drug. Arzneimittelforschung. 34:1984;885-890.
13. Scion Image for Windows (based on NIH Image for MacIntosh by Wayne Rasband of National Institute of Health, USA), Release Beta 4.0.2, Scion, USA.
14. Shen X.Z., Koo M.W.L., Cho C.H. Sleep deprivation increase the expression of inducible heat shock protein 70 in rat gastric mucosa. World Journal of Gastroenterology. 7:2001;496-499.
15. Shin V.Y., Liu E.S.L., Koo M.W.L., Wang J.Y., Matsui H., Cho C.H. Cigarette smoke extracts delay wound healing in the stomach: involvement of polyamine synthesis. Experimental Biology and Medicine. 227:2002;114-124.
16. Sun W.H., Tsuji S., Tsujii M., Gunawan E.S., Kawai N., Kimura A., Kakiuchi Y., Yasumaru M., Iijima H., Okuda Y., Sasaki Y., Hori M., Kawano S. Induction of cyclooxygenase-2 in rat gastric mucosa by rebamipide, a mucoprotective agent. Journal of Pharmacology and Experimental Therapeutics. 295:2000;447-452.
17. Suzuki K., Araki H., Komoike Y., Takeuchi K. Permissive role of neutrophils in pathogenesis of indomethacin-induced gastric lesions in rats. Medical Science Monitor. 6:2000;908-914.
18. Suzuki T., Kagoshima M., Shimada H. Evaluation of HCl-induced gastric mucosal lesions using a computer image processing system. Nippon Yakurigaku Zasshi. 98:1991;91-98.
19. Szabo S., Trier J.S., Brown A., Schnoor J., Homan H.D., Bradford J.C. A quantitative method for assessing the extent of experimental gastric erosions and ulcers. Journal of Pharmacological Methods. 13:1985;59-66.
20. Takeuchi K., Okada M., Ueshima K., Ohuchi T., Okabe S. Endogenous sulfhydryls in healing gastric mucosal injury induced by HCl in the rat. Digestion. 54:1993;91-97.
21. Tepperman B.L., Vozzolo B.L., Soper B.D. Effect of neutropenia on gastric mucosal integrity and mucosal nitric oxide synthesis in the rat. Digestive Diseases and Sciences. 38:1993;2056-2061.
22. Trapkov V.A., Boudunova A.P., Burova O.A., Filimonov D.A., Poroikov V.V. Discovery of new antiulcer agents by computer aided prediction of biological activity. Problems in Medicinal Chemistry. 43:1997;41-57.
23. Tuncel N., Erkasap N., Sahinturk V., Ak D.D., Tuncel M. The protective effect of vasoactive intestinal peptide (VIP) on stress-induced gastric ulceration in rats. Annals of New York Academy of Sciences. 865:1998;309-322.
24. Umemoto M., Nakamura S., Okumura S., Sekiguchi T., Nishihara T., Nishimura T., Hayashi S. Evaluation of the anti-ulcer drugs using image analysis technology: effect of aldioxa containing preparation on the experimental gastric ulcer in rats. Nippon Yakurigaku Zasshi. 94:1989;281-287.
25. Valcavi U., Caponi R., Brambilla A., Palmira F., Minoja F., Bernin F., Mustani R., Fumagall R. Gastric antisecretory, antiulcer and cytoprotective properties of 9-hydroxy-19,20-bis-norprostanoid acid in experimental animals. Arzneimittelforschung. 32:1982;657-663.
26. Vincze A., Kiraly A., Suto G., Mozsik G. Is acute surgical vagotomy an aggressor to gastric mucosa in pylorus ligated rats with and without indomethacin treatment. Acta Physiologica Hungaria. 80:1992;195-203.
27. Wallace J.L., Keenan C.M., Granger D.N. Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process. American Journal of Physiology. 259:1990;G462-G467.
28. Watanabe T., Arakawa T., Tominaga K., Fujiwara Y., Higuchi K., Kuroki T. Neutrophil accumulation in development of gastric ulcer induced by submucosal injection of endothelin-1 in rats. Digestive Diseases and Sciences. 45:2000;880-888.