Improved synthesis of DQ-113, a new quinolone antibacterial agent,utilizing the Reformatsky reaction

Arkivoc

Volumn 2003, Issue 8, 2003, Pages 112-117

  Inagaki, Hiroaki ^a   Sugita, Kazuyuki ^a   Miyauchi, Rie N ^a   Miyauchi, Satoru ^a   Takeda, Toshiyuki ^a   Itoh, Masao ^a   Takahashi, Hisashi ^a   Takemura, Makoto ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

DQ 113; Reformatsky reaction

Indexed keywords

5 AMINO 7 [4 (1 AMINOCYCLOPROP 1 YL) 3 FLUOROPYRROLIDIN 1 YL] 6 FLUORO 1 (2 FLUOROCYCLOPROP 1 YL) 1,4 DIHYDRO 8 METHYL 4 OXOQUINOLINE 3 CARBOXYLIC ACID; ACETIC ACID DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; DQ 113; ETHYL 1 ACETYLCYCLOPROPANECARBOXYLATE; ETHYLBROMOFLUOROACETATE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; GRAM POSITIVE BACTERIUM; REFORMATSKY REACTION; TEMPERATURE SENSITIVITY;

EID: 1342301097     PISSN: 14246376     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (3)

1. Inagaki, H.; Miyauchi, S.; Miyauchi, R. N.; Kawato, H. C.; Ohki, H; Matsuhashi, N.; Kawakami, K.; Takahashi, H.; Takemura, M. J. Med. Chem. 2003, 46, 1005.
2. Tanaka, M.; Yamazaki, E.; Chiba, M.; Yoshihara, K.; Akasaka, T.; Takemura, M.; Sato, K. Antimicrob. Agents Chemother. 2002, 46, 904.
3. Matsumoto, T.; Shirahama, H.; Ichihara, A.; Shin, H.; Kagawa, S.; Hisamitsu, T.; Kamada, T.; Sakan, F. Bull. Chem. Soc. Jap. 1972, 45, 1136.