Effects of biotin on pyruvate carboxylase, acetyl-CoA carboxylase, propionyl-CoA carboxylase, and markers for glucose and lipid homeostasis in type 2 diabetic patients and nondiabetic subjects

American Journal of Clinical Nutrition

Volumn 79, Issue 2, 2004, Pages 238-243

  Báez Saldaña, Armida ^a   Zendejas Ruiz, Iván ^c   Revilla Monsalve, Cristina ^b   Islas Andrade, Sergio ^b   Cárdenas, Araceli ^b   Rojas Ochoa, Alberto ^a   Vilches, Alonso ^a   Fernandez Mejia, Cristina ^a,d  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b INSTITUTO MEXICANO DEL SEGURO SOCIAL   (Mexico)

^c INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

^d Instituto Nacional de Ciencias Médicas Y Nutrición ^*  (Mexico)

Author keywords

Acetyl CoA carboxylase; Biotin; Propionyl CoA carboxylase; Pyruvate carboxylase; Type 2 diabetes

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; BIOCHEMICAL MARKER; BIOTIN; CHOLESTEROL; GLUCOSE; INSULIN; LACTIC ACID; LIPID; PROPIONYL COENZYME A CARBOXYLASE; PYRUVATE CARBOXYLASE; TRIACYLGLYCEROL; METHYLMALONYL COENZYME A DECARBOXYLASE;

ARTICLE; CELL ACTIVITY; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; GLUCOSE HOMEOSTASIS; HUMAN; LIPID METABOLISM; LYMPHOCYTE; METABOLITE; NON INSULIN DEPENDENT DIABETES MELLITUS; ADULT; AGED; BLOOD; CLINICAL TRIAL; DRUG EFFECT; ENZYMOLOGY; FEMALE; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; MALE; MIDDLE AGED;

ACETYL-COA CARBOXYLASE; ADULT; AGED; BIOTIN; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; FEMALE; HOMEOSTASIS; HUMANS; LIPIDS; MALE; METHYLMALONYL-COA DECARBOXYLASE; MIDDLE AGED; PYRUVATE CARBOXYLASE;

EID: 1342286111     PISSN: 00029165     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcn/79.2.238     Document Type: Article

References (35)

1. Mock DM, Quirk JG, Mock NI. Marginal biotin deficiency during normal pregnancy. Am J Clin Nutr 2002;75:295-9.
2. Mock DM, Stadler DD, Stratton SL, Mock NI. Biotin status assessed longitudinally in pregnant women. J Nutr 1997;127:710-6.
3. Bonjour JP. Biotin in man's nutrition and therapy - a review. Int J Vitam Nutr Res 1977;47:107-18.
4. Maebashi M, Makino Y, Furukawa Y, Ohinata K, Kimura S, Takao S. Therapeutic evaluation of the effect of biotin on hyperglycemia in patients with non-insulin diabetes mellitus. J Clin Biochem Nutr 1993;14:211-8.
5. Coggeshall JC, Heggers JP, Robson MC, Baker H. Biotin status and plasma glucose levels in diabetics. Ann N Y Acad Sci 1985;447:389-92.
6. Dakshinamurti K, Modi VV, Mistry SP. Biotin deficiency produces hyperglycemia. Proc Soc Exp Biol Med 1968;127:396-400.
7. Deodhar AD, Mistry SP. Regulation of glycolysis in biotin-deficient rat liver. Life Sci II 1970;9:581-8.
8. Koustikos D, Fourtounas C, Kapetanaki A, et al. Oral glucose test after high-dose i.v. biotin administration in normoglucemic hemodialysis patients. Ren Fail 1996;18:131-7.
9. Reddi A, DeAngelis B, Frank O, Lasker N, Baker H. Biotin supplementation improves glucose and insulin tolerances in genetically diabetic KK mice. Life Sci 1988;42:1323-30.
10. Zhang H, Osada K, Maebashi M, Ito M, Komai M, Furukawa Y. A high biotin diet improves the impaired glucose tolerance of long-term spontaneously hyperglycemic rats with non-insulin-dependent diabetes mellitus. J Nutr Sci Vitaminol (Tokyo) 1996;42:517-26.
11. Chauhan J, Dakshimamurti K. Transcriptional regulation of the glucokinase gene by biotin in starved rats. J Biol Chem 1991;266:10035-8.
12. Romero-Navarro G, Cabrera-Valladares G, German MS, Matschinsky FM, Wang J, Fernandez-Mejia C. Biotin regulation of pancreatic glucokinase and insulin in primary cultured rat islets and in biotin-deficient rats. Endocrinology 1999;140:4595-600.
13. Dakshinamurti K, Li W. Transcriptional regulation of the liver phosphoenolpyruvate carboxykinase by biotin in diabetic rats. Mol Cell Biochem 1994;132:127-32.
14. Mock DM, Mock NI. Lymphocyte propionyl-CoA carboxylase is an early and sensitive indicator of biotin deficiency in rats, but urinary excretion of 3-hydroxypropionic acid is not. J Nutr 2002;132:1945-50.
15. Velázquez A, Terán M, Báez A, Gutierrez J, Rodríguez R. Biotin supplementation affects lymphocyte carboxylases and plasma biotin in severe protein-energy malnutrition. Am J Clin Nutr 1995;61:385-91.
16. Whitehead CC. The assessment of biotin status in man and animals. Proc Nutr Soc 1981;140:165-72.
17. Báez-Saldaña A, Díaz G, Espinoza B, Ortega E. Biotin deficiency induces changes in subpopulations of spleen lymphocytes in mice. Am J Clin Nutr 1998;67:431-7.
18. Mock NI, Malik MI, Stumbo PJ, Bishop WP, Mock DM. Increased urinary excretion of 3-hydroxyisovaleric acid and decreased urinary excretion of biotin are sensitive early indicators of decreased biotin status in experimental biotin deficiency. Am J Clin Nutr 1997;65:951-8.
19. Mock DM, Henrich CL, Carnell N, Mock NI. Indicators of marginal biotin deficiency and repletion in humans: validation of 3-hydroxyisovaleric acid excretion and a leucine challenge. Am J Clin Nutr 2002;76:1061-8.
20. Weinberg MB, Utter MF. Effect of streptozotocin-induced diabetes mellitus on the turnover of the rat liver pyruvate carboxylase and pyruvate dehydrogenase. Biochem Genet 1980;188:601-8.
21. MacDonald MJ, Efendic S, Ostenson CG. Normalization by insulin treatment of low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of the GK rat. Diabetes 1996;45:886-90.
22. MacDonald MJ, Tang J, Polonsky KS. Low mitochondrial glycerol phosphate dehydrogenase and pyruvate carboxylase in pancreatic islets of Zucker diabetic fatty rats. Diabetes 1996;45:1626-30.
23. Katsurada A, Iritani N, Fukuda H, et al. Effects of nutrients and hormones on transcriptional and post-transcriptional regulation of acetyl-CoA carboxylase in rat liver. Eur J Biochem 1990;190:435-41.
24. Pape ME, Lopez-Casillas F, Kim KH. Physiological regulation of acetyl-CoA carboxylase gene expression: effects of diet, diabetes, and lactation on acetyl-CoA carboxylase mRNA. Arch Biochem Biophys 1988;267:104-9.
25. Jitrapakdee S, Wallace JC. Structure, function and regulation of pyruvate carboxylase. Biochem Genet 1999;340:1-16.
26. Kim KH. Regulation of mammalian acetyl-coenzyme A carboxylase. Annu Rev Nutr 1997;17:77-99.
27. Wolf B, Rosenberg LE. Stimulation of propionyl CoA and beta-methylcrotonyl CoA carboxylase activities in human lymphocytes and cultured fibroblasts by biotin. Pediatr Res 1979;13:1275-9.
28. Bartlett K, Horsburgh T, Gompertz D. The relationship between plasma biotin concentration and circulating leucocyte beta-methylcrotonyl-CoA carboxylase and propionyl-CoA carboxylase. Clin Sci 1980;58:111-4.
29. Manthey KC, Griffin JB, Zempleni J. Biotin supply affects expression of biotin transporters, biotinylation of carboxylases and metabolism of interleukin-2 in Jurkat cells. J Nutr 2002;132:887-92.
30. Wolf B, Hsia YE. Biotin responsiveness in propionicacidaemia. Lancet 1978;21:901.
31. Marshall MW, Smith BP, Lehman RP. Dietary response of two genetically different lines of inbred rats: lipids in serum and liver. Proc Soc Exp Biol Med 1969;131:1271-7.
32. Scott D. Clinical biotin deficiency report of a case with some remarks on serum cholesterol. Acta Med Scand 1958;162:69-70.
33. Marshall MW, Kliman PG, Washington VA. Effects of biotin on lipids and other constituents of plasma of healthy men and women. Artery 1980;7:330-51.
34. Dukusova OD, Krivoruchenko IV. [The effect of biotin on the level of cholesterol in the blood of patients with atherosclerosis and essential hyperlipidemia.] Kardiologiia 1972;12:113(in Russian).
35. Furukawa Y. Enhancement of glucose-induced insulin secretion and modification of glucose metabolism by biotin. Nippon Rinsho 1999;57:2261-9.