Synthesis and blood-schizontocidal antimalarial activities of 2-substituted/2,5-disubstituted-8-quinolinamines and some of their amino acid conjugates

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 5, 2004, Pages 1003-1010

  Jain, Meenakshi ^a   Vangapandu, Suryanarayana ^a,b   Sachdeva, Sandeep ^a   Jain, Rahul ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

^b UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

2 tert Butylprimaquine; 8 Quinolinamines; Blood schizontocides; Malaria

Indexed keywords

2 TERT BUTYLPRIMAQUINE; AMINE; AMINO ACID DERIVATIVE; ANTIMALARIAL AGENT; CHLOROQUINE; N 1 [4 (2 TERT BUTYL 6 METHOXY 8 QUINOLYLAMINO)PENTYL] 2 AMINO 3 METHYLBUTANAMIDE; N 1 [4 (2 TERT BUTYL 6 METHOXY 8 QUINOLYLAMINO)PENTYL] 2 AMINOPROPANAMIDE; N 1 [4 (2 TERT BUTYL 6 METHOXY 8 QUINOLYLAMINO)PENTYL] 2,6 DIAMINOHEXANAMIDE; N 1 [4 (TERT BUTYL 6 METHOXY 8 QUINOLYLAMINO)PENTYL] 2,5 DIAMINOPENTAMIDE; N 8 (4 AMINO 1 METHYLBUTYL) 2 CYCLOHEXYL 5,6 DIMETHOXY 8 QUINOLINAMINE; N 8 (4 AMINO 1 METHYLBUTYL) 2 CYCLOHEXYL 6 METHOXY 8 QUINOLINAMINE; N 8 (4 AMINO 1 METHYLBUTYL) 2 CYCLOPENTYL 6 METHOXY 8 QUINOLINAMINE; N 8 (4 AMINO 1 METHYLBUTYL) 2 ISOPROPYL 5,6 DIMETHOXY 8 QUINOLINAMINE; N 8 (4 AMINO 1 METHYLBUTYL) 2 ISOPROPYL 6 METHOXY 8 QUINOLINAMINE; N 8 (4 AMINO 1 METHYLBUTYL) 2 TERT BUTYL 5,6 DIMETHOXY 8 QUINOLINAMINE; N 8 (4 AMINO 1 METHYLBUTYL) 2,5 DICYCLOHEXYL 6 METHOXY 8 QUINOLINAMINE; N 8 (4 AMINO 1 METHYLBUTYL) 2,5 DICYCLOPENTYL 6 METHOXY 8 QUINOLINAMINE; N 8 (4 AMINO 1 METHYLBUTYL) 2,5 DIISOPROPYL 6 METHOXY 8 QUINOLINAMINE; PRIMAQUINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONJUGATION; DRUG POTENCY; DRUG SYNTHESIS; IN VIVO STUDY; MALARIA; MOUSE; NONHUMAN; PLASMODIUM BERGHEI; PLASMODIUM YOELII; PROTOZOON;

EID: 1342279560     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.12.029     Document Type: Article

References (10)

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10. The resolution studies on primaquine (Carroll, F. I.; Berrang, B. Linn, C. P. J. Med. Chem. 1978, 21, 326) indicate that both enantiomers possess similar antimalarial activities, and primaquine is used clinically as racemate. Thus, in this study, attempts were not made to separate (R, S) and (S, S) diastereoisomers of synthesized 8-quinolinamine conjugates (45-48).