Pituitary-Thyroid State Correlates with Central Dopaminergic and Serotonergic Activity in Healthy Humans

Neuropsychobiology

Volumn 49, Issue 2, 2004, Pages 84-87

  Strawn, J R ^a   Ekhator, N N ^b   D'Souza, B B ^b   Geracioti Jr , T D ^b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b NONE

Author keywords

5 Hydroxyindolacetic acid; Central nervous system; Cerebrospinal fluid; Dopamine; Homovanillic acid; Serotonin; Thyroid stimulating hormone; Thyrotropin; Thyroxine; Triiodothyronine

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; HOMOVANILLIC ACID; LIOTHYRONINE; THYROTROPIN; THYROXINE;

ADULT; ARTICLE; BLOOD SAMPLING; CEREBROSPINAL FLUID ANALYSIS; CEREBROSPINAL FLUID CYTOLOGY; CONTROLLED STUDY; DOPAMINERGIC ACTIVITY; FEMALE; HUMAN; HYPOPHYSIS THYROID SYSTEM; INDWELLING CATHETER; INTRAVENOUS CATHETER; LIOTHYRONINE BLOOD LEVEL; MALE; NORMAL HUMAN; PRIORITY JOURNAL; SEROTONINERGIC NERVE; SUBARACHNOID SPACE; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

ADULT; CENTRAL NERVOUS SYSTEM; DIET, PROTEIN-RESTRICTED; DOPAMINE; FEMALE; HOMOVANILLIC ACID; HUMANS; HYDROXYINDOLEACETIC ACID; MALE; PITUITARY GLAND; REGRESSION ANALYSIS; SEROTONIN; THYROID GLAND; THYROTROPIN;

EID: 1342269751     PISSN: 0302282X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000076415     Document Type: Article

References (15)

1. Aronson R, Offman HJ, Joffe RT, Naylor CD: Triiodothyronine augmentation in the treatment of refractory depression. A meta-analysis. Arch Gen Psychiatry 1996;53:842-848.
2. Altshuler LL, Bauer M, Frye MA, Gitlin MJ, Mintz J, Szuba MP, Leight KL, Whybrow PC: Does thyroid supplementation accelerate tricyclic antidepresssant response? A review and meta-analysis of the literature. Am J Psychiatry 2001;158:1617-1622.
3. Gold MS, Pottash ALC, Extein I: Hypothyroidism and depression: Evidence from complete thyroid evaluation. JAMA 1981;245:1919-1922.
4. Cleare AJ, McGregor A, Chambers SM, Dawling S, O'Keane V: Thyroxine replacement increases central 5-hydroxytryptamine activity and reduces depressive symptoms in hypothyroidism. Neuroendocrinology 1996;64:65-69.
5. Cleare AJ, McGregor A, O'Keane V: Neuroendocrine evidence for an association between hypothyroidism, reduced central 5-HT activity and depression. Clin Endocrinol (Oxf) 1995;43:713-719.
6. Gold PW, Goodwin FK, Wehr T, Rebar R: Pituitary thyrotropin response to thyrotropin-releasing hormone in affective illness: Relationship to spinal fluid amine metabolites. Am J Psychiatry 1977;134:1028-1031.
7. Peabody CA, Whiteford HA, Warner MD, Faull KF, Barchas JD, Berger PA: TRH stimulation test and depression. Psychiatry Res 1987;22:21-28.
8. Sjöberg S, Eriksson M, Nordin C: L-Thyroxine treatment and neurotransmitter levels in the cerebrospinal fluid of hypothyroid patients: A pilot study. Eur J Endocrinol 1998;139:493-497.
9. Kamal TJ, Molitch ME: Effects of calcium channel blockade with verapamil on the prolactin responses to TRH, L-dopa and bromocriptine. Am J Med Sci 1992;304:289-293.
10. Hill KK, West SA, Ekhator NN, Bruce AB, Wortman MD, Baker DG, Geracioti TD Jr: The effect of lumbar puncture stress on dopamine and serotonin metabolites in human cerebrospinal fluid. Neurosci Lett 1999;276:25-28.
11. Geracioti TD Jr, Orth DN, Ekhator NN, Blumenkopf B, Loosen PT: Serial cerebrospinal fluid corticotropin-releasing hormone concentrations in healthy and depressed humans. J Clin Endocrinol Metab 1992;74:1325-1330.
12. Strawn JR, Ekhator NN, Geracioti TD: In-use stability of monoamine metabolites in cerebrospinal fluid. J Chromatogr B 2001;760:301-306.
13. Strawn JR, Ekhator NN, Anthenelli RM, Baker DG, Maxwell RA, Hill KK, Geracioti TD: Intra-and interindividual relationships between central and peripheral serotonergic activity in humans: A serial cerebrospinal fluid sampling study. Life Sci 2002;71:1219-1225.
14. Bauer M, Heinz A, Whybrow PC: Thyroid hormones, serotonin and mood: Of synergy and significance in the adult brain. Mol Psychiatry 2002;7:140-156.
15. Sandrini M, Vitale G, Vergoni AV, Ottani A, Bertolini A: Effect of acute and chronic treatment with triiodothyronine on serotonin levels and serotonergic receptor subtypes in the rat brain. Life Sci 1996;58:1551-1559.