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Volumn 286, Issue 3 55-3, 2004, Pages

Delineation of responsive AVP-containing neurons to running stress in the hypothalamus

Author keywords

Arginine vasopressin; Paraventricular nucleus; Stalk median eminence; Supraoptic nucleus

Indexed keywords

ARGIPRESSIN; CORTICOTROPIN; LACTIC ACID; PROTEIN FOS;

EID: 1342267995     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00453.2003     Document Type: Article
Times cited : (43)

References (49)
  • 1
    • 0025972326 scopus 로고
    • The effect of acute exercise on the secretion of corticotropin-releasing factor, arginine vasopressin, and adrenocorticotropin as measured in pituitary venous blood from the horse
    • Alexander SL, Irvine CH, Ellis MJ, and Donald RA. The effect of acute exercise on the secretion of corticotropin-releasing factor, arginine vasopressin, and adrenocorticotropin as measured in pituitary venous blood from the horse. Endocrinology 128: 65-72, 1991.
    • (1991) Endocrinology , vol.128 , pp. 65-72
    • Alexander, S.L.1    Irvine, C.H.2    Ellis, M.J.3    Donald, R.A.4
  • 2
    • 0022820123 scopus 로고
    • Hypothalamic control of adrenocorticotropin secretion: Advances since the discovery of 41-residue corticotropin-releasing factor
    • Antoni FA. Hypothalamic control of adrenocorticotropin secretion: advances since the discovery of 41-residue corticotropin-releasing factor. Endocr Rev 7: 351-378, 1986.
    • (1986) Endocr Rev , vol.7 , pp. 351-378
    • Antoni, F.A.1
  • 3
    • 0025255524 scopus 로고
    • Corticotrophin-releasing peptides in rat hypophysial portal blood after paraventricular lesions: A marked reduction in the concentration of corticotrophin-releasing factor-41, but no change in vasopressin
    • Antoni FA, Fink G, and Sheward WJ. Corticotrophin-releasing peptides in rat hypophysial portal blood after paraventricular lesions: a marked reduction in the concentration of corticotrophin-releasing factor-41, but no change in vasopressin. J Endocrinol 125: 175-183, 1990.
    • (1990) J Endocrinol , vol.125 , pp. 175-183
    • Antoni, F.A.1    Fink, G.2    Sheward, W.J.3
  • 4
    • 0002369892 scopus 로고
    • Hypothalamic supraoptic and paraventricular nuclei
    • edited by Paxinos G. San Diego, CA: Academic
    • Armstrong EW. Hypothalamic supraoptic and paraventricular nuclei. In: The Rat Nervous System (2nd ed.), edited by Paxinos G. San Diego, CA: Academic, 1995, p. 377-390.
    • (1995) The Rat Nervous System (2nd Ed.) , pp. 377-390
    • Armstrong, E.W.1
  • 5
    • 16744367186 scopus 로고
    • Portal vascular route from hypophysial stalk/neural lobe to adenohypophysis
    • Baertschi AJ. Portal vascular route from hypophysial stalk/neural lobe to adenohypophysis. Am J Physiol Regul Integr Comp Physiol 239: R463-R469, 1980.
    • (1980) Am J Physiol Regul Integr Comp Physiol , vol.239
    • Baertschi, A.J.1
  • 6
    • 0022337923 scopus 로고
    • Improved detection of lactate threshold during exercise using a log-log transformation
    • Beaver WL, Wasserman K, and Whipp BJ. Improved detection of lactate threshold during exercise using a log-log transformation. J Appl Physiol 59: 1936-1940, 1985.
    • (1985) J Appl Physiol , vol.59 , pp. 1936-1940
    • Beaver, W.L.1    Wasserman, K.2    Whipp, B.J.3
  • 7
    • 0018408599 scopus 로고
    • Pituitary-brain vascular relations: A new paradigm
    • Bergland RM and Page RB. Pituitary-brain vascular relations: a new paradigm. Science 204: 18-24, 1979.
    • (1979) Science , vol.204 , pp. 18-24
    • Bergland, R.M.1    Page, R.B.2
  • 8
    • 0024386517 scopus 로고
    • Hypoglycemia enhances turnover of corticotropin-releasing factor and of vasopressin in the zona externa of the rat median eminence
    • Berkenbosch F, De Goeij DC, and Tilders FJ. Hypoglycemia enhances turnover of corticotropin-releasing factor and of vasopressin in the zona externa of the rat median eminence. Endocrinology 125: 28-34, 1989.
    • (1989) Endocrinology , vol.125 , pp. 28-34
    • Berkenbosch, F.1    De Goeij, D.C.2    Tilders, F.J.3
  • 9
    • 0018129989 scopus 로고
    • Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat. Pathways to the limbic system, medulla oblongata and spinal cord
    • Buijs RM. Intra- and extrahypothalamic vasopressin and oxytocin pathways in the rat. Pathways to the limbic system, medulla oblongata and spinal cord. Cell Tissue Res 192: 423-435, 1978.
    • (1978) Cell Tissue Res , vol.192 , pp. 423-435
    • Buijs, R.M.1
  • 10
    • 0023114931 scopus 로고
    • Ultrastructural demonstration of oxytocin and vasopressin release sites in the neural lobe and median eminence of the rat by tannic acid and immunogold methods
    • Buma P and Nieuwenhuys R. Ultrastructural demonstration of oxytocin and vasopressin release sites in the neural lobe and median eminence of the rat by tannic acid and immunogold methods. Neurosci Lett 74: 151-157, 1987.
    • (1987) Neurosci Lett , vol.74 , pp. 151-157
    • Buma, P.1    Nieuwenhuys, R.2
  • 11
    • 0019377949 scopus 로고
    • Plasma volume, osmolality, vasopressin, and renin activity during graded exercise in man
    • Convertino VA, Keil LC, Bernauer EM, and Greenleaf JE. Plasma volume, osmolality, vasopressin, and renin activity during graded exercise in man. J Appl Physiol 50: 123-128, 1981.
    • (1981) J Appl Physiol , vol.50 , pp. 123-128
    • Convertino, V.A.1    Keil, L.C.2    Bernauer, E.M.3    Greenleaf, J.E.4
  • 12
    • 0026782730 scopus 로고
    • Chronic stress enhances vasopressin but not corticotropin-releasing factor secretion during hypoglycemia
    • De Goeij DC, Binnekade R, and Tilders FJ. Chronic stress enhances vasopressin but not corticotropin-releasing factor secretion during hypoglycemia. Am J Physiol Endocrinol Metab 263: E394-E399, 1992.
    • (1992) Am J Physiol Endocrinol Metab , vol.263
    • De Goeij, D.C.1    Binnekade, R.2    Tilders, F.J.3
  • 13
    • 0026597057 scopus 로고
    • Repeated stress enhances vasopressin synthesis in corticotropin releasing factor neurons in the paraventricular nucleus
    • De Goeij DC, Jezova D, and Tilders FJ. Repeated stress enhances vasopressin synthesis in corticotropin releasing factor neurons in the paraventricular nucleus. Brain Res 577: 165-168, 1992.
    • (1992) Brain Res , vol.577 , pp. 165-168
    • De Goeij, D.C.1    Jezova, D.2    Tilders, F.J.3
  • 14
    • 0032032571 scopus 로고    scopus 로고
    • Properties and glial origin of osmotic-dependent release of taurine from the rat supraoptic nucleus
    • Deleuze C, Duvoid A, and Hussy N. Properties and glial origin of osmotic-dependent release of taurine from the rat supraoptic nucleus. J Physiol 507: 463-471, 1998.
    • (1998) J Physiol , vol.507 , pp. 463-471
    • Deleuze, C.1    Duvoid, A.2    Hussy, N.3
  • 15
    • 0021033110 scopus 로고
    • Plasma adrenocorticotropin and cortisol responses to submaximal and exhaustive exercise
    • Farrell PA, Garthwaite TL, and Gustafson AB. Plasma adrenocorticotropin and cortisol responses to submaximal and exhaustive exercise. J Appl Physiol 55: 1441-1444, 1983.
    • (1983) J Appl Physiol , vol.55 , pp. 1441-1444
    • Farrell, P.A.1    Garthwaite, T.L.2    Gustafson, A.B.3
  • 16
    • 0023192805 scopus 로고
    • Enkephalins, catecholamines, and psychological mood alterations: Effects of prolonged exercise
    • Farrell PA, Gustafson AB, Morgan WP, and Pert CB. Enkephalins, catecholamines, and psychological mood alterations: effects of prolonged exercise. Med Sci Sports Exerc 19: 347-353, 1987.
    • (1987) Med Sci Sports Exerc , vol.19 , pp. 347-353
    • Farrell, P.A.1    Gustafson, A.B.2    Morgan, W.P.3    Pert, C.B.4
  • 17
    • 0033838532 scopus 로고    scopus 로고
    • Effects of adrenergic and serotonergic agonists in the amygdala on the hypothalamo-pituitary-adrenocortical axis
    • Feldman S, Newman ME, and Weidenfeld J. Effects of adrenergic and serotonergic agonists in the amygdala on the hypothalamo-pituitary-adrenocortical axis. Brain Res Bull 52: 531-536, 2000.
    • (2000) Brain Res Bull , vol.52 , pp. 531-536
    • Feldman, S.1    Newman, M.E.2    Weidenfeld, J.3
  • 18
    • 0025093178 scopus 로고
    • Oxytocin neurons in the rat hypothalamus exhibit c-fos immunoreactivity upon osmotic stress
    • Giovannelli L, Shiromani PJ, Jirikowski GF, and Bloom FE. Oxytocin neurons in the rat hypothalamus exhibit c-fos immunoreactivity upon osmotic stress. Brain Res 531: 299-303, 1990.
    • (1990) Brain Res , vol.531 , pp. 299-303
    • Giovannelli, L.1    Shiromani, P.J.2    Jirikowski, G.F.3    Bloom, F.E.4
  • 19
    • 0020407025 scopus 로고
    • The effect of serotonin agonist 1-(trifluoromethylphenyl)-piperazine on corticotropin releasing factor and arginine vasopressin in rat hypothalamic nuclei
    • Hashimoto K, Ohno N, Murakami K, Kageyama J, Aoki Y, and Takahara J. The effect of serotonin agonist 1-(trifluoromethylphenyl)-piperazine on corticotropin releasing factor and arginine vasopressin in rat hypothalamic nuclei. Endocrinol Jpn 29: 383-388, 1982.
    • (1982) Endocrinol Jpn , vol.29 , pp. 383-388
    • Hashimoto, K.1    Ohno, N.2    Murakami, K.3    Kageyama, J.4    Aoki, Y.5    Takahara, J.6
  • 20
    • 0022657736 scopus 로고
    • Magnocellular axons in passage through the median eminence release vasopressin
    • Holmes M, Antoni FA, Aguilera G, and Catt KJ. Magnocellular axons in passage through the median eminence release vasopressin. Nature 319: 326-329, 1986.
    • (1986) Nature , vol.319 , pp. 326-329
    • Holmes, M.1    Antoni, F.A.2    Aguilera, G.3    Catt, K.J.4
  • 22
    • 0023749844 scopus 로고
    • Neuronal activity of the cat supraoptic nucleus is influenced by muscle small-diameter afferent (groups III and IV) receptors
    • Kannan H, Yamashita H, Koizumi K, and Brooks CM. Neuronal activity of the cat supraoptic nucleus is influenced by muscle small-diameter afferent (groups III and IV) receptors. Proc Natl Acad Sci USA 85: 5744-5748, 1988.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 5744-5748
    • Kannan, H.1    Yamashita, H.2    Koizumi, K.3    Brooks, C.M.4
  • 23
    • 0001228695 scopus 로고
    • Corticotropin-releasing factor-immunoreactive neurons of the paraventricular nucleus become vasopressin positive after adrenalectomy
    • Kiss JZ, Mezey E, and Skirboll L. Corticotropin-releasing factor-immunoreactive neurons of the paraventricular nucleus become vasopressin positive after adrenalectomy. Proc Natl Acad Sci USA 81: 1854-1858, 1984.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 1854-1858
    • Kiss, J.Z.1    Mezey, E.2    Skirboll, L.3
  • 24
    • 0030959827 scopus 로고    scopus 로고
    • Identification of hypothalamic vasopressin and oxytocin neurons activated during the exercise pressor reflex in cats
    • Li J, Hand GA, Potts JT, and Mitchell JH. Identification of hypothalamic vasopressin and oxytocin neurons activated during the exercise pressor reflex in cats. Brain Res 752: 45-51, 1997.
    • (1997) Brain Res , vol.752 , pp. 45-51
    • Li, J.1    Hand, G.A.2    Potts, J.T.3    Mitchell, J.H.4
  • 25
    • 0031014769 scopus 로고    scopus 로고
    • Direct hypertonic stimulation of the rat supraoptic nucleus increases c-fos expression in glial cells rather than magnocellular neurones
    • Ludwig M, Johnstone LE, Neumann I, Landgraf R, and Russell JA. Direct hypertonic stimulation of the rat supraoptic nucleus increases c-fos expression in glial cells rather than magnocellular neurones. Cell Tissue Res 287: 79-90, 1997.
    • (1997) Cell Tissue Res , vol.287 , pp. 79-90
    • Ludwig, M.1    Johnstone, L.E.2    Neumann, I.3    Landgraf, R.4    Russell, J.A.5
  • 26
    • 0033953678 scopus 로고    scopus 로고
    • LPS-induced Fos expression in oxytocin and vasopressin neurons of the rat hypothalamus
    • Matsunaga W, Miyata S, Takamata A, Bun H, Nakashima T, and Kiyohara T. LPS-induced Fos expression in oxytocin and vasopressin neurons of the rat hypothalamus. Brain Res 858: 9-18, 2000.
    • (2000) Brain Res , vol.858 , pp. 9-18
    • Matsunaga, W.1    Miyata, S.2    Takamata, A.3    Bun, H.4    Nakashima, T.5    Kiyohara, T.6
  • 27
    • 0033378556 scopus 로고    scopus 로고
    • Endogenous vasopressin modulates the cardiovascular responses to exercise
    • Michelini LC and Morris M. Endogenous vasopressin modulates the cardiovascular responses to exercise. Ann NY Acad Sci 897: 198-211, 1999.
    • (1999) Ann NY Acad Sci , vol.897 , pp. 198-211
    • Michelini, L.C.1    Morris, M.2
  • 28
    • 0028956232 scopus 로고
    • Temporal changes of c-fos expression in oxytocinergic magnocellular neuroendocrine cells of the rat hypothalamus with restraint stress
    • Miyata S, Itoh T, Lin SH, Ishiyama M, Nakashima T, and Kiyohara T. Temporal changes of c-fos expression in oxytocinergic magnocellular neuroendocrine cells of the rat hypothalamus with restraint stress. Brain Res Bull 37: 391-395, 1995.
    • (1995) Brain Res Bull , vol.37 , pp. 391-395
    • Miyata, S.1    Itoh, T.2    Lin, S.H.3    Ishiyama, M.4    Nakashima, T.5    Kiyohara, T.6
  • 29
    • 0034122368 scopus 로고    scopus 로고
    • Stressor-specific activation of the hypothalamic-pituitary-adrenocortical axis
    • Pacak K. Stressor-specific activation of the hypothalamic-pituitary-adrenocortical axis. Physiol Res 49: S11-S17, 2000.
    • (2000) Physiol Res , vol.49
    • Pacak, K.1
  • 31
    • 0022970572 scopus 로고
    • Co-existence of CRF and vasopressin immunoreactivity in parvocellular paraventricular neurons of rat hypothalamus
    • Piekut DT and Joseph SA. Co-existence of CRF and vasopressin immunoreactivity in parvocellular paraventricular neurons of rat hypothalamus. Peptides 7: 891-898, 1986.
    • (1986) Peptides , vol.7 , pp. 891-898
    • Piekut, D.T.1    Joseph, S.A.2
  • 32
    • 0020471229 scopus 로고
    • Electrophysiology of hypothalamic magnocellular neurones secreting oxytocin and vasopressin
    • Poulain DA and Wakerley JB. Electrophysiology of hypothalamic magnocellular neurones secreting oxytocin and vasopressin. Neuroscience 7: 773-808, 1982.
    • (1982) Neuroscience , vol.7 , pp. 773-808
    • Poulain, D.A.1    Wakerley, J.B.2
  • 33
    • 0023678749 scopus 로고
    • β-Endorphin and corticotropin release is dependent on a threshold intensity of running exercise in male endurance athletes
    • Rahkila P, Hakala E, Alen M, Salminen K, and Laatikainen T. β-Endorphin and corticotropin release is dependent on a threshold intensity of running exercise in male endurance athletes. Life Sci 43: 551-558, 1988.
    • (1988) Life Sci , vol.43 , pp. 551-558
    • Rahkila, P.1    Hakala, E.2    Alen, M.3    Salminen, K.4    Laatikainen, T.5
  • 34
    • 0027263982 scopus 로고
    • c-fos expression in vasopressin and oxytocin neurons reveals functional heterogeneity within magnocellular neurons
    • Roberts MM, Robinson AG, Fitzsimmons MD, Grant F, Lee WS, and Hoffman GE. c-fos expression in vasopressin and oxytocin neurons reveals functional heterogeneity within magnocellular neurons. Neuroendocrinology 57: 388-400, 1993.
    • (1993) Neuroendocrinology , vol.57 , pp. 388-400
    • Roberts, M.M.1    Robinson, A.G.2    Fitzsimmons, M.D.3    Grant, F.4    Lee, W.S.5    Hoffman, G.E.6
  • 35
    • 0026006171 scopus 로고
    • c-fos mRNA, Fos, and Fos-related antigen induction by hypertonic saline and stress
    • Sharp FR, Sagar SM, Hicks K, Lowenstein D, and Hisanaga K. c-fos mRNA, Fos, and Fos-related antigen induction by hypertonic saline and stress. J Neurosci 11: 2321-2331, 1991.
    • (1991) J Neurosci , vol.11 , pp. 2321-2331
    • Sharp, F.R.1    Sagar, S.M.2    Hicks, K.3    Lowenstein, D.4    Hisanaga, K.5
  • 36
    • 0026688097 scopus 로고
    • Hypotension preferentially induces c-fos immunoreactivity in supraoptic vasopressin neurons
    • Shen E, Dun SL, Ren C, Bennett-Clarke C, and Dun NJ. Hypotension preferentially induces c-fos immunoreactivity in supraoptic vasopressin neurons. Brain Res 593: 136-139, 1992.
    • (1992) Brain Res , vol.593 , pp. 136-139
    • Shen, E.1    Dun, S.L.2    Ren, C.3    Bennett-Clarke, C.4    Dun, N.J.5
  • 37
    • 0025942808 scopus 로고
    • Corticotropin-releasing hormone is not the sole factor mediating exercise-induced adrenocorticotropin release in humans
    • Smoak B, Deuster P, Rabin D, and Chrousos G. Corticotropin-releasing hormone is not the sole factor mediating exercise-induced adrenocorticotropin release in humans. J Clin Endocrinol Metab 73: 302-306, 1991.
    • (1991) J Clin Endocrinol Metab , vol.73 , pp. 302-306
    • Smoak, B.1    Deuster, P.2    Rabin, D.3    Chrousos, G.4
  • 38
    • 0037891284 scopus 로고    scopus 로고
    • Stress response to exercise and its hypothalamic regulation: Role of arginine-vasopressin
    • edited by Nose H, Gisolfi CV, and Imaizumi K. Traverse City, MI: Cooper
    • Soya H. Stress response to exercise and its hypothalamic regulation: role of arginine-vasopressin. In: Exercise, Nutrition and Environmental Stress, edited by Nose H, Gisolfi CV, and Imaizumi K. Traverse City, MI: Cooper, 2001, p. 21-37.
    • (2001) Exercise, Nutrition and Environmental Stress , pp. 21-37
    • Soya, H.1
  • 39
    • 0025174911 scopus 로고
    • A possible role of hypothalamic somatostatin in the maintenance of rat pituitary responsiveness to growth hormone-releasing factor
    • Soya H and Suzuki M. A possible role of hypothalamic somatostatin in the maintenance of rat pituitary responsiveness to growth hormone-releasing factor. Endocrinology 126: 285-291, 1990.
    • (1990) Endocrinology , vol.126 , pp. 285-291
    • Soya, H.1    Suzuki, M.2
  • 40
    • 0020645737 scopus 로고
    • Hypothalamic integration: Organization of the paraventricular and supraoptic nuclei
    • Swanson LW and Sawchenko PE. Hypothalamic integration: organization of the paraventricular and supraoptic nuclei. Annu Rev Neurosci 6: 269-324, 1983.
    • (1983) Annu Rev Neurosci , vol.6 , pp. 269-324
    • Swanson, L.W.1    Sawchenko, P.E.2
  • 42
    • 0026856798 scopus 로고
    • The benefits of the low intensity training
    • Tanaka H and Shindo M. The benefits of the low intensity training. Ann Physiol Anthropol 11: 365-368, 1992.
    • (1992) Ann Physiol Anthropol , vol.11 , pp. 365-368
    • Tanaka, H.1    Shindo, M.2
  • 43
    • 0026065034 scopus 로고
    • Corticotrophin-releasing factor-41, vasopressin and oxytocin release into hypophysial portal blood in the rat: Effects of electrical stimulation of the hypothalamus, amygdala and hippocampus
    • Tannahill LA, Sheward WJ, Robinson IC, and Fink G. Corticotrophin-releasing factor-41, vasopressin and oxytocin release into hypophysial portal blood in the rat: effects of electrical stimulation of the hypothalamus, amygdala and hippocampus. J Endocrinol 129: 99-107, 1991.
    • (1991) J Endocrinol , vol.129 , pp. 99-107
    • Tannahill, L.A.1    Sheward, W.J.2    Robinson, I.C.3    Fink, G.4
  • 44
    • 0028301563 scopus 로고
    • Effect of anaesthetizing the region of the paraventricular hypothalamic nuclei on energy metabolism during exercise in the rat
    • Van Dijk G, Vissing J, Steffens AB, and Galbo H. Effect of anaesthetizing the region of the paraventricular hypothalamic nuclei on energy metabolism during exercise in the rat. Acta Physiol Scand 151: 165-172, 1994.
    • (1994) Acta Physiol Scand , vol.151 , pp. 165-172
    • Van Dijk, G.1    Vissing, J.2    Steffens, A.B.3    Galbo, H.4
  • 46
    • 0021683114 scopus 로고
    • Response, regulation, and actions of vasopressin during exercise: A review
    • Wade CE. Response, regulation, and actions of vasopressin during exercise: a review. Med Sci Sports Exerc 16: 506-511, 1984.
    • (1984) Med Sci Sports Exerc , vol.16 , pp. 506-511
    • Wade, C.E.1
  • 47
    • 0027460680 scopus 로고
    • Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system
    • Whitnall MH. Regulation of the hypothalamic corticotropin-releasing hormone neurosecretory system. Prog Neurobiol 40: 573-629, 1993.
    • (1993) Prog Neurobiol , vol.40 , pp. 573-629
    • Whitnall, M.H.1
  • 48
    • 0030575283 scopus 로고    scopus 로고
    • Release of vasopressin from supraoptic neurons within the median eminence in vivo. A combined microdialysis and push-pull perfusion study in the rat
    • Wotjak CT, Kubota M, Kohl G, and Landgraf R. Release of vasopressin from supraoptic neurons within the median eminence in vivo. A combined microdialysis and push-pull perfusion study in the rat. Brain Res 726: 237-241, 1996.
    • (1996) Brain Res , vol.726 , pp. 237-241
    • Wotjak, C.T.1    Kubota, M.2    Kohl, G.3    Landgraf, R.4
  • 49
    • 0036460740 scopus 로고    scopus 로고
    • Vasopressin from hypothalamic magnocellular neurons has opposite actions at the adenohypophysis and in the supraoptic nucleus on ACTH secretion
    • Wotjak CT, Ludwig M, Ebner K, Russell JA, Singewald N, Landgraf R, and Engelmann M. Vasopressin from hypothalamic magnocellular neurons has opposite actions at the adenohypophysis and in the supraoptic nucleus on ACTH secretion. Eur J Neurosci 16: 477-485, 2002.
    • (2002) Eur J Neurosci , vol.16 , pp. 477-485
    • Wotjak, C.T.1    Ludwig, M.2    Ebner, K.3    Russell, J.A.4    Singewald, N.5    Landgraf, R.6    Engelmann, M.7


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