Circular dichroism simulation shows a site-II-to-site-I displacement of human serum albumin-Bound diclofenac by ibuprofen

AAPS PharmSciTech

Volumn 1, Issue 2, 2000, Pages

  Yamasaki, Keishi ^a,b   Rahman, Mohammed Habibur ^a,b   Tsutsumi, Yasuhiro ^a,b   Marumaya, Toru ^a,b   Ahmed, Shamim ^a,b   Kragh Hansen, Ulrich ^a,b   Otagiri, Masaki ^a,b  

^a KUMAMOTO UNIVERSITY   (Japan)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Circular dichroism simulation; Diclofenac; Human serum albumin; Ibuprofen; Site II to site I displacement

Indexed keywords

DICLOFENAC; HUMAN SERUM ALBUMIN; IBUPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT; SERUM ALBUMIN;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BINDING SITE; CIRCULAR DICHROISM; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DISPOSITION; DRUG PROTEIN BINDING; EQUILIBRIUM DIALYSIS; HYPOTHESIS; MATHEMATICAL COMPUTING; SIMULATION; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; DRUG EFFECT; HUMAN; METABOLISM; METHODOLOGY; PROTEIN BINDING;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BINDING SITES; BINDING, COMPETITIVE; CIRCULAR DICHROISM; COMPUTER SIMULATION; DICLOFENAC; HUMANS; IBUPROFEN; MODELS, CHEMICAL; PROTEIN BINDING; SERUM ALBUMIN;

EID: 1342267704     PISSN: 15309932     EISSN: 15309932     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Kober A, Sjöholm I. The binding sites on human serum albumin for some nonsteroidal antiinflammatory drugs. Mol Pharmacol. 1980; 18: 421-426.
2. Kragh-Hansen U. Molecular aspects of ligand binding to serum albumin. Pharmacol Rev. 1981; 33: 17-53.
3. Peters T. Jr. All about albumin. Biochemistry, genetics, and medical applications. Academic Press, San Diego. 1996.
4. Fehske KJ, Muller WE, Wollert U. The location of drug binding sites in human serum albumin. Biochem Pharmacol. 1981; 30: 687-692.
5. Rahman MH, Maruyama T, Okada T, Imai T, Otagiri M. Study of interaction of carprofen and its enantiomers with human serum albumin-II. Stereoselective site-to-site displacement of carprofen by ibuprofen. Biochem Pharmacol. 1993; 46: 1733-1740.
6. Chamouard J-M, Barre J, Urien S, Houin G, Tillement JP. Diclofenac binding to albumin and lipoproteins in human serum. Biochem Pharmacol. 1985; 34: 1695-1700.
7. Chen RF. Removal of fatty acids from serum albumin by charcoal treatment. J Biol Chem. 1967; 242: 173-183.
8. Rahman MH, Maruyama T, Okada T, Yamasaki K, Otagiri M. Study of interaction of carprofen and its enantiomers with human serum albumin-I. Mechanism of binding studied by dialysis and spectroscopic methods. Biochem Pharmacol. 1993; 46: 1721-1731.
9. Yamaoka K, Tanigawara Y, Nakagawa T, Uno T. A pharmacokinetic analysis program (MULTI) for microcomputer. J Pharmacobio-Dyn. 1981; 4: 879-885.
10. Rahman MH, Yamasaki K, Shin Y-H, Lin CC, Otagiri M. Characterization of high affinity binding sites of nonsteroidal anti-inflammatory drugs with respect to site-specific probes on human serum albumin. Biol Pharm Bull. 1993; 16: 1169-1174.
11. Tonn GR, Kerr CR, Axelson JE. In vitro protein binding of propafenone and 5-hydroxypropafenone in serum, in solutions of isolated serum proteins, and to red blood cells. J Pharm Sci. 1992; 81: 1098-1103.
12. Otagiri M, Otagiri Y, Perrin JH. Some fluorescent investigation of the interaction between the enantiomers of warfarin and human serum albumin. Int J Pharm. 1979; 2: 283-294.