Incidentally discovered adrenocortical adenomas are not fully nonfunctioning: Immunohistochemical and dispersed adrenocortical cell study

Endocrine Journal

Volumn 43, Issue 1, 1996, Pages 79-86

  Tobinaga, Junichi ^a   Imai, Tsuneo ^a   Funahashi, Hiroomi ^a   Tanaka, Yuji ^a   Wada, Masaki ^a   Morita, Takako ^a   Yamada, Fumio ^a   Tsukamura, Kyosuke ^a   Oiwa, Mikinao ^a   Kikumori, Toyone ^a   Sasano, Hironobu ^b   Takagi, Hiroshi ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Adrenal gland; Dispersed cell; Immunohistochemistry; Incidentaloma; Nonfunctioning adenoma

Indexed keywords

ADRENAL CORTEX ADENOMA; ADRENAL GLAND; ADULT; ARTICLE; CLINICAL ARTICLE; FEMALE; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE RELEASE; MALE; STEROIDOGENESIS; TUMOR LOCALIZATION;

EID: 13344294386     PISSN: 09188959     EISSN: None     Source Type: Journal    
DOI: 10.1507/endocrj.43.79     Document Type: Article

References (18)

1. Copeland PM (1984) The incidentally discovered adrenal mass. Ann Surg 199: 116-122.
2. Glazer HS, Weyman PJ, Sagel SS, Levitt RG, McClennan BL (1982) Nonfunctioning adrenal masses: Incidental discovery on computed tomography. Am J Roentogenol 139: 81-85.
3. Geelhoed GW, Dury EM (1982) Management of the adrenal "incidentaloma". Surgery 92: 866-874.
4. Thompson NW, Cheung PSY (1987) Diagnosis and treatment of functioning and nonfunctioning adrenocortical neoplasms including incidentalomas. Surg Clin North Amer 67: 423-436.
5. Sasano H, Mason JI, Sasano N, Nagura H (1990) Immunolocalization of 3β-hydroxysteroid dehydrogenase in human adrenal cortex and in its disorders. Endocr Pathol 1: 94-101.
6. Sasano H, Okamoto M, Sasano N (1988) Immunohistochemical study of cytochrome P-450 11β-hydroxylase in human adrenal cortex with mineralo- and glucocorticoid excess. Virchows Archiv (A Pathol Anat) 413: 313-318.
7. Imai T, Globerman H, Gertner JM, Kagawa N, Waterman MR (1993) Expression and purification of functional human 17α-hydroxylase/17, 20-lyase (P450c17) in Escherichia coll J Biol Chem 268: 19681-19689.
8. Sasano H, Sasano N, Okamoto M (1989) Immunohistochemical demonstration of cholesterol side-chain cleavage cytochrome P-450 in bovine and human adrenals. Path Res Pract 184: 337-342.
9. Sasano H, White PC, New MI, Sasano N (1988) Immunohistochemical localization of cytochrome P-450c21 in human adrenal cortex and its relation to endocrine function. Hum Pathol 19: 181-185.
10. Kloppenborg PWC, Island DP, Liddle GW, Michelakis AM, Nicholson WE (1968) A method of preparing adrenal cell suspensions and its applicability to the in vitro study of adrenal metabolism. Endocrinology 82: 1053-1058.
11. Mizuno S, Funahashi H (1981) Biosynthesis of various steroids in vitro by isolated adrenal cells in primary aldosteronism, Cushing's syndrome, and adrenogenital syndrome due to adrenocortical adenoma. Nagoya J Med Sci 44: 11-22.
12. Suzuki H, Shibata H, Takita T, Wakino S, Ogishima T, Ishimura Y, Saruta T (1994) Steroid contents and cortical steroidogenic enzymes in non-hyperfunctioning adrenal adenoma. Endocrine J 41: 267-274.
13. Kaplan NM (1967) The steroid content of adrenal adenomas and measurements of aldosterone production in patients with essential hypertension and primary aldosteronism. J Clin Invest 51: 2239-2245.
14. Matsuo K, Kawai K, Tsuchiyama H (1985) Non-functioning adrenocortical adenoma in culture. Acta Pathol Jpn 35: 871-874.
15. Noritake M, Morimoto K, Kosano H, Nemoto Y, Kugai N, Takao M, Murai M, Tamai S, Tanaka K, Nagata N (1992) A case of asymptomatic cortisol producing adrenal adenoma. Endocrinol Japon 39: 19-24.
16. Imai T, Seo H, Murata Y, Funahashi H, Satoh Y, Sasano H, Matsui N, Takagi H (1991) Dexamethasone-nonsuppressible cortisol in two cases with aldosterone-producing adenoma. J Clin Endocrinol Metab 72: 575-581.
17. Cugini P, Campisi C, Castagna G, Battisti P, Di Palma L, Coppola A, Di Palma M, Sasaki H, Uezono K, Kawasaki T (1992) Pre-Cushing's syndrome: A case report. Endocrinol Japon 39: 407-11.
18. Nozaki H, Funahashi H, Sato Y, Imai T, Asano M, Ueda M, Yoshida N, Kato N, Ando K, Takagi H (1989) Four cases of non-Cushingoid Cushing's syndrome. Endocrine Surgery 6: 91-95.