Lack of in vitro interaction between heparin and nitroglycerin

American Journal of Clinical Pathology

Volumn 105, Issue 3, 1996, Pages 298-300

  Barnes, Drew D ^a   Horn, John R ^a   Wittkowsky, Ann K ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Activated partial thromboplastin time; Drug interaction; Heparin; Nitroglycerin

Indexed keywords

GLYCERYL TRINITRATE; HEPARIN;

ANTICOAGULANT THERAPY; ARTICLE; DRUG EFFECT; HEPARINIZATION; HUMAN; NORMAL HUMAN; PARTIAL THROMBOPLASTIN TIME; PLASMA; PRIORITY JOURNAL;

EID: 13344294371     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcp/105.3.298     Document Type: Article

References (15)

1. Hirsh J, Raschke R, Warkentin TE, et al. Heparin: mechanism of action, pharmacokinetics, dosing considerations, monitoring, efficacy and safety. Chest 1995;108(suppl4):258-275.
2. Abrams J. Glyceryl trinitrate (nitroglycerin) and the organic nitrates. Drugs 1987;34:391-403.
3. Habbab MA, Haft JI. Intravenous nitroglycerin and heparin resistance [Letter]. Ann Intern Med 1986;105:305.
4. Pye M, Oldroyd KG, Conkie JA, et al. A clinical and in vitro study on the possible interaction of intravenous nitrates with heparin anticoagulation. Clin Cardiol 1994;17:658-661.
5. Brack MJ, More RS, Hubner PJ, Gershlick AH. The effect of different nitrate preparations on plasma heparin concentrations and the activated partial thromboplastin time. Postgrad Med J 1994;70:100-103.
6. Habbab MA, Haft JI. Heparin resistance induced by intravenous nitroglycerin. Arch Intern Med 1987;147:857-860.
7. Becker RC, Corrao JM, Bovill EG. Intravenous nitroglycerin-induced heparin resistance: A qualitative antithrombin III abnormality. Am Heart J 1990;119:1254-1261.
8. Lepor NE, Amin DK, Berberian L, et al. Does nitroglycerin induce heparin resistance? Clin Cardiol 1989;12:432-434.
9. Bode V, Welzel D, Franz G, et al. Absence of drug interaction between heparin and nitroglycerin. Arch Intern Med 1990;150: 2117-2119.
10. Schoenenberger RA, Menat L, Weiss P, et al. Absence of nitroglycerin-induced heparin resistance in healthy volunteers. Eur Heart J 1992;13:411-414.
11. Gonzalez ER, Jones HD, Graham S, et al. Assessment of the drug interaction between intravenous nitroglycerin and heparin. Ann Pharmacother 1992;26:1512-1514.
12. Berk SI, Grunwald A, Pal S, et al. Effect of intravenous nitroglycerin on heparin dosage requirements in coronary artery disease. Am J Cardiol 1993;72:393-396.
13. Curry SH, Aburawi SM. Analysis, disposition and pharmacokinetics of nitroglycerin. Biopharm Drug Disp 1985;6:235-280.
14. Stanek EJ, Nair RN, Munger MA. Nitroglycerin-induced heparin resistance [Letter]. Am Heart J 1991;121:1849-1850.
15. Kandrotas RJ. Heparin pharmacokinetics and pharmacodynamics. Clin Pharmacokinet 1992;22:359-372.