Particulate naturally processed peptides prime a cytotoxic response against human melanoma in vitro

Cancer Research

Volumn 56, Issue 6, 1996, Pages 1210-1213

  Protti, Maria Pia ^a   Imro, Maria Adele ^a   Manfredi, Angelo A ^a   Consogno, Giuseppe ^a   Heltai, Silvia ^a   Arcelloni, Cinzia ^a   Bellone, Matteo ^a   Dellabona, Paolo ^a   Casorati, Giulia ^a   Rugarli, Claudio ^a,b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE;

ANTIGEN PRESENTING CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; CYTOTOXICITY TEST; DNA TRANSFECTION; HUMAN; HUMAN CELL; MELANOMA; PRIORITY JOURNAL;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, NEOPLASM; HLA-A ANTIGENS; HUMANS; MELANOMA; MICE; T-LYMPHOCYTES, CYTOTOXIC;

EID: 13344284629     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Slingluff, C L., Hunt, D. F., and Engelhard, V. H. Direct analysis of tumor-associated antigens Curr Opin. Immunol , 6: 733-740, 1994.
2. Boon, T , Cerottini, J. C., Van den Eynde, B., Van der Bruggen, P., and Van Pel, A. Tumor antigens recognized by T lymphocytes. Annu. Rev. Immunol , 12: 337-365, 1994.
3. Mueller, D. L., Jenkins, M. K., and Schwartz, R. H. Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T-cell antigen receptor occupancy. Annu. Rev. Immunol., 7: 445-480, 1989.
4. Huang, A. Y. C., Golumbek, P , Ahmadzadeh, M., Jaffee, E., Pardoll, D., and Levitsky, H. Role of bone marrow-derived cells in presenting MHC class-I- restricted tumor antigens. Science (Washington DC), 264: 961-965, 1994.
5. Franksson, L., Petersson, M., Kiessling, R., and Karre, K. Immunization against tumor and minor histocompatibility antigens by eluted cellular peptides loaded on antigen processing defective cells. Eur. J. Immunol., 23: 2606-2613, 1993
6. Mandelboim, O., Berke, G., Fridkin, M., Feldman, M., Eisenstein, M., and Eisenbach, L. CTL induction by a tumor-associated antigen octapeptide derived from a murine lung carcinoma. Nature (Lond ), 369: 67-71, 1994.
7. Bellone, M., Iezzi, G., Manfredi, A. A., Protti, M. P., Dellabona, P., Casorati, G , and Rugarli, C. In vitro priming of cytotoxic T lymphocytes against poorly immunogenic epitopes by engineered antigen-presenting cells. Eur. J Immunol., 24: 2691-2698, 1994.
8. Rammensee, H-G , Falk, K., and Rotzschke, O. Peptides naturally presented by MHC class I molecules. Annu Rev. Immunol., 11: 213-244, 1993.
9. Falk, K., Rotzschke, O , and Rammensee, H-G. Cellular peptide composition governed by major histocompatibility complex class I molecules. Nature (Lond.), 348: 195-197, 1990.
10. Townsend, A., and Bodmer, H. Antigen recognition by class I-restricted T lymphocytes. Annu. Rev. Immunol., 7: 601-624, 1989.
11. Christinck, E. R , Luscher, M A., Barber, B. H., and Williams, D. B. Peptide binding to class I MHC on living cells and quantitation of complexes required for CTL lysis. Nature (Lond ), 352: 67-70, 1991.
12. Zhou, F , Rousse, B. T., and Huang, L J. Induction of cytotoxic T lymphocytes in vivo with protein antigen entrapped in membranous vehicles. J. Immunol., 149: 1599-1604, 1992.
13. Rock, K. L., Rothstein, L , Gamble, S., and Fleischacker, C. J. Characterization of antigen-presenting cells that present exogenous antigens in association with class I MHC molecules. J Immunol., 150: 438-446, 1993.
14. Kovacsovics-Bankowski, M., Clark, K., Benacerraf, B., and Rock, K. L Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages. Proc Natl. Acad. Sci. USA, 90: 4942-4946, 1993.
15. Pfeifer, J. D., Wick, M J., Roberts, R. L., Findlay, K., Normak, S. J., and Harding, C V Phagocytic processing of bacterial antigens for class I MHC presentation to T cells. Nature (Lond.), 361: 359-362, 1993.
16. Harding, C. V., and Song, R. Phagocytic processing of exogenous particulate antigens by macrophages for presentation by MHC class I molecules J Immunol., 153: 4925-4933, 1994
17. Kovacsovics-Bankowski, M., and Rock, K. L. A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science (Washington DC), 267: 243-246, 1995
18. De Bruijin, M. L. H., Jackson, M. R., and Peterson, P. A Phagocyte-induced antigen-specific activation of umprimed CD8+ T cells in vitro. Eur. J. Immunol., 25: 1274-1285, 1995.
19. Falo, L. D., Jr., Kovacsovics-Bankowski, M., Thompson, K., and Rock, K L. Targeting antigen into the phagocytic pathway in vivo induces protective tumor immunity. Nat. Med., 7: 649-653, 1995.
20. Towsend, A., Oholen, C., Bastin, J., Ljiunggren, H G , Foster, L., and Karre, K. Association of class I major histocompatibility heavy and light chains induced by viral peptides. Nature (Lond ), 340: 443-448, 1989.
21. Celis, E., Tsai, V., Crimi, C., DeMars, R., Wentworth, P A , Chesnut, R. W., Grey, H M., Sette, A , and Serra, H. M. Induction of anti-tumor cytotoxic T lymphocytes in normal humans using primary cultures and synthetic peptide epitopes. Proc Natl. Acad. Sci. USA, 91. 2105-2109, 1994.
22. Van Der Bruggen, P., Bastin, J., Gajewski, T., Coulie, P G , Boel, P., De Smet, C., Traversan, C., Townsend, A , and Boon, T. A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3. Eur. J. Immunol., 24. 3038-3043, 1994.
23. Visseren, M J. W., Van Elsa, A., Van Voort, E. I. H., Ressing, M. E., Kast, W. M., Schrier, P. I., and Melief, C. J. M. CTL specific for the tyrosinase autoantigen can be induced from healthy donor blood to lyse melanoma cells. J. Immunol., 154: 3991-3998, 1995.