Clonal dominance of human autologous cytotoxic T lymphocytes against gastric carcinoma: Molecular stability of the CDR3 structure of the TCRαβ gene

International Immunology

Volumn 8, Issue 1, 1996, Pages 75-82

  Ikeda, Hideyuki ^a   Sato, Noriyuki ^a   Matsuura, Akihiro ^a   Sasaki, Aya ^a   Takahashi, Shuji ^a   Kozutsumi, Daisuke ^a   Kobata, Tetsuji ^b   Okumura, Ko ^c   Wada, Yoshimasa ^a   Hirata, Koichi ^a   Kikuchi, Kokichi ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c JUNTENDO UNIVERSITY   (Japan)

Author keywords

Cytotoxic T lymphocyte; TCR genes

Indexed keywords

T LYMPHOCYTE RECEPTOR;

ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; GENE STRUCTURE; HUMAN; HUMAN CELL; LYMPHOCYTE CLONE; MOLECULAR STABILITY; NUCLEOTIDE SEQUENCE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNET RING CARCINOMA; STOMACH CARCINOMA;

AMINO ACID SEQUENCE; ANTIGENS, CD3; BASE SEQUENCE; BLOTTING, SOUTHERN; CARCINOMA, SIGNET RING CELL; CELL LINE; CELLS, CULTURED; CLONE CELLS; HUMANS; MOLECULAR SEQUENCE DATA; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; STOMACH NEOPLASMS; T-LYMPHOCYTES, CYTOTOXIC;

EID: 13344278701     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/8.1.75     Document Type: Article

References (30)

1. Crowley, N. J . Darrow, T L , Quinn-Allen, M A and Seigler, H F 1991 MHC-restncted recognition of autologous melanoma by tumor-specific cytotoxic T cells. J. Immunol. 146:1692
2. Ioannides, C. G., Freedman, R S., Platsoucas, C D , Bashed, S and Kim, Y. P. 1991 Cytotoxic T cell clones isolated from ovarian tumor-infiltrating lymphocytes recognize multiple antigenic epitopes on autologous tumor cells. J Immunol. 146:700
3. Mukherji, B., Guha, A, Chakraborty, N G., Sivanandham, M , Nashed, A L , Sporn, J R. and Ergin, M. T. 1989. Clonal analysis of cytotoxic and regulatory T cell responses against human melanomas. J Exp Med. 169:1961
4. Sato, T., Sato, N., Koshiba, H. and Kikuchi, K. 1986. Specific cytotoxicity of a long term cultured T cell clone on human autologous mammary cancer cells Cancer Res. 46:4384.
5. Okubo, M., Sato, N, Wada, Y, Takahashi, S., Torimoto, K., Takahashi, N., Sato, T., Okazaki, M., Asaishi, K. and Kikuchi, K. 1989 Identification by monoclonal antibody of the tumor antigen of a human autologous breast cancer cell that is involved in cytotoxicity by a cytotoxic T-cell clone. Cancer Res 49:3950.
6. Sato, N., Wada, Y., Ikeda, H., Takahashi, S., Tsuboi, N., Kishi, A., Hirata. K. and Kikuchi, K. 1993. Role of tumor-associated antigens in induction of specific killing by cytotoxic T lymphocytes in human autologous cancers. Gann Monogr. Cancer Res. 40:107.
7. Wada, Y, Ikeda, H., Ueda, D., Ohta, M., Takahashi, S., Hirata, K., Sato, N. and Kikuchi, K 1993. Brefeldin A blocks the cytotoxicity of T cell receptor αβ and γ/δ cytotoxic T lymphocyte clones reacting against human autologous cancer cells. Jap J Cancer Res. 84:906.
8. Ikeda, H., Sato, N., Matsuura, A and Kikuchi, K. 1993. Analysis of T cell receptor V region gene usage of cytotoxic T-lymphocytes and tumor-infiltrating lymphocytes derived from human autologous gastric signet ring cell carcinomas Cancer Res. 53:3078.
9. Clothia, C. D., Boswell, D. R. and Lesk, A. M. 1988 The outline structure of the T-cell αβ receptor EMBO J. 7:3745
10. Geiger, M. J . Gorski, J. and Eckels, D D. 1991. T cell receptor gene segment utilization by HLA-DR1-alloreactive T cell clones. J. Immunol 147:2082.
11. Davis, M M. and Bjorkman, P J. 1988. T-cell antigen receptor genes and T-cell recognition. Nature 334:395.
12. Wada, Y, Ikeda, H., Ueda. D., Ohta, M., Takahashi, S., Hirata, K., Sato, N. and Kikuchi, K. 1992. In vitro proliferation and the cytotoxic specificity of a cryopreserved cytotoxic T cell clone reacting against human autologous tumor cells. J Immunol. Methods 154:235.
13. Sambrook, J , Fritsch, E F. and Maniatis. T. 1989. Molecular Cloning: A Laboratory Manual, 2nd edn. p 7-19 Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY
14. Panzara, M. A, Gussoni, E., Steinman, L and Oksenberg, J. R. 1992. Analysis of the T cell repertoire using the PCR and specific oligonucleotide primers. BioTechniques 12:728
15. Saiki, R K., Gelfand, D. H., Stoffel, S , Scharf, S. J., Higuchi, R , Horn, G, T., Mullis, K. B and Erlich, H. A. 1988. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487.
16. Yoshikai, Y, Kimura, N., Toyonaga, B and Mak, T. W 1986. Sequences and repertoire of human T cell receptor α chain variable region genes in mature T lymphocytes. J Exp. Med. 164:90.
17. Sim, G. K., Yagüe, J., Nelson, J , Marrack, P, Palmer, E., Augustin, A. and Kappler, J. 1984 Primary structure of human T-cell receptor α-chain. Nature 312:771
18. Klein, M H., Concannon, P., Everett, M , Kim, L D H , Hunkapiller, T. and Hood, L. 1987. Diversity and structure of human T-cell receptor α-chain variable region genes. Proc. Natl Acad. Sci. USA 84:6884
19. Leiden, J M and Strominger, J L. 1986 Generation of diversity of the β chain of the human T-lymphocyte receptor for antigen Proc Natl Acad Sci USA 83:4456
20. Toyonaga, B , Yoshikai, Y, Vadasz, V, Chin, B. and Mak, T. W. 1985 Organization and sequences of the diversity, joining, and constant region genes of the human T-cell receptor β chain. Proc. Natl Acad Sci USA 82:8624
21. Concannon, P., Pickering, L. A., Kung, P and Hood, L. 1986 Diversity and structure of human T-celi receptor β-chain variable region genes Proc Natl Acad Sci. USA 83:6598,
22. Kimura, N , Toyonaga, B, Yoshikai, Y, Du, R.-P. and Mak, T. W 1987 Sequences and repertoire of the human T cell receptor α and β chain variable region genes in thymocytes. Eur. J. Immunol 17:375.
23. Kimura, N., Toyonaga, B., Yoshikai, Y, Triebel, F., Debre, P., Minden, M D and Mak, T W. 1986 Sequences and diversity of human T cell receptor β chain variable region genes. J. Exp. Med 164:739
24. Bjorkman, P. J., Saper, M. A , Samraoui, B , Bennett, W. S., Strominger, J L. and Wiley, D C. 1987. The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329:512.
25. Hirama, T., Takeshita, S., Matsubayashi, Y, Iwashiro, M, Masuda, T., Kuribayashi, K., Yoshida, Y and Yamagishi, H. 1991. Conserved V (D) J junctional sequence of cross-reactive cytotoxic T cell receptor idiotype and the effect of a single amino acid substitution Eur. J Immunol. 21:483.
26. Vacchio, W S , Granger, L., Kanagawa, O., Malissen, B., Tomonari, K., Sharrow, S. O and Hodes, R. J 1993 T cell receptor Vα-Vβ combinatorial selection in the expressed T cell repertoire. J. Immunol, 151:1322,
27. Mackensen, A., Ferradini, L., Carcelain, G., Triebel, F., Faure, F. Viel, S and Hercend, T. 1993 Evidence for in situ amplification of cytotoxic T-lymphocytes with antitumor activity in a human regressive melanoma. Cancer Res. 53:3569
28. Monaco, J J 1992. A molecular model of MHC class I-restricted antigen processing, Immunol. Today 13:173.
29. Wallny, H. J and Rarnmensee. H G 1990. Identification of classical minor histocompatibility antigen as cell-derived peptide. Nature 343:275.
30. Slingluff, C L., Cox, A L., Henderson, R. A., Hunt, D. F. and Engelhard, V. H. 1993. Recognition of human melanoma cells by HLA-A2 1-restricted cytotoxic T lymphocytes is mediated by at least six shared peptide epitopes. J. Immunol. 150:2955.