Osmotic swelling stimulates ascorbate efflux from cerebral astrocytes

Journal of Neurochemistry

Volumn 66, Issue 3, 1996, Pages 1227-1233

  Siushansian, Ramin ^a   Jeffrey Dixon, S ^a   Wilson, John X ^a  

^a UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

Ascorbate; Astrocytes; Cell volume; Intracellular concentration; Transport

Indexed keywords

ASCORBIC ACID;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN CORTEX; BRAIN EDEMA; BRAIN INJURY; BRAIN ISCHEMIA; CELLULAR DISTRIBUTION; DRUG TRANSPORT; NEUROMODULATION; NONHUMAN; OSMOSIS; PRIORITY JOURNAL; RAT;

ANIMALIA;

EID: 13344278005     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66031227.x     Document Type: Article

References (47)

1. Bender A. S. and Norenberg M. D. (1994) Calcium dependence of hypoosmotically induced potassium release in cultured astrocytes. J. Neurosci. 14, 4237-4243.
2. Dixon S. J. and Wilson J. X. (1995) Fluorescence measurement of cytosolic pH in cultured rodent astrocytes. Methods Neurosci. 27, 196-213.
3. Fabian R. H., DeWitt D. S., and Kent T. A. (1995) In vivo detection of superoxide anion production by the brain using a cytochrome c electrode J. Cereb Blood Flow Metab. 15, 242-247.
4. Flamm E. S., Demopoulos H. B., Seligman M. L., Poser R. G., and Ransohoff J. (1978) Free radicals in cerebral ischemia. Stroke 9, 445-447.
5. Grünewald R. A. (1993) Ascorbic acid in the brain. Brain Res. Rev. 18, 123-133.
6. Gullans S. R. and Verbalis J. G. (1993) Control of brain volume during hyperosmolar and hypoosmolar conditions. Annu. Rev. Med. 44, 289-301.
7. Hillered L., Persson L., Bolander H. G., Hallstrom A., and Ungerstedt U. (1988) Increased levels of ascorbate in the striatum after middle cerebral artery occlusion in the rat monitored by intracerebral microdialysis. Neurosci. Lett. 95, 286-290.
8. Hillered L., Nilsson P., Ungerstedt U., and Ponten U. (1990) Trauma-induced increase of extracellular ascorbate in rat cerebral cortex. Neurosci. Lett. 113, 328-332.
9. Ikeda Y. and Long D. M. (1990) The molecular basis of brain injury and brain edema' the role of oxygen free radicals. Neurosurgery 27, 1-11.
10. Isaacks R. E., Bender A. S., Kim C. Y., Prieto N. M., and Norenberg M. D. (1994) Osmotic regulation of myo-inositol uptake in primary astrocyte cultures. Neurochem. Res. 19, 331-338.
11. Jackson P. S., Morrison R., and Strange K. (1994) The volume-sensitive organic osmolyte-anion channel VSOAC is regulated by nonhydrolytic ATP binding. Am. J. Physiol. 267, C1203-C1209.
12. Karibe H., Chen S. F., Zarow G. J., Gafni J., Graham S. H., Chan P. H., and Weinstein P. R. (1994) Mild intraischemic hypothermia suppresses consumption of endogenous antioxidants after temporary focal ischemia in rats. Brain Res. 649, 12-18.
13. Kimelberg H. K. (1992) Astrocytic edema in CNS trauma J. Neurotrauma 9, S71-S81.
14. Kimelberg H. K. and Kettenmann H. (1990) Swelling-induced changes in electrophysiological properties of cultured astrocytes and oligodendrocytes. E. Effects on membrane potentials, input impedance and cell-cell coupling. Brain Res. 529, 255-261.
15. Kimelberg H. K., Goderie S. K., Higman S., Pang S., and Waniewski R. A. (1990) Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures. J. Neurosci. 10, 1583-1591.
16. Kinouchi H., Epstein C. J., Mizui T., Carlson E., Chen S. F., and Chan P. H. (1991) Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase. Proc. Natl. Acad. Sci. USA 88, 11158-11162.
17. Kinuta Y., Kikuchi H., Ishikawa M., Kimura M., and Itokawa Y. (1989) Lipid peroxidation in focal cerebral ischaemia. J. Neurosurg. 71, 421-429.
18. Landolt H., Lutz T. W., Langemann H., Stauble D., Mendelowitsch A., Gratzl O., and Honegger C. G. (1992) Extracellular antioxidants and amino acids in the cortex of the rat: monitoring by microdialysis of early ischemic changes. J. Cereb. Blood Flow Metab. 12, 96-102.
19. Law R. O. (1995) Taurine efflux and the regulation of cell volume in incubated slices of rat cerebral cortex. Biochim. Biophys. Acta 1221, 21-28.
20. Lien Y.-H. H., Shapiro J. I., and Chan L. (1990) Effects of hypernatremia on organic brain osmoles. J. Clin. Invest. 85, 1427-1435
21. Lowry O. H., Rosebrough N. J., Farr A. L., and Raudall R. J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
22. Lyrer P., Landolt H., Kabiersch A., Langemann H., and Kaeser H. (1991) Levels of low molecular weight scavengers in the rat brain during focal ischemia. Brain Res. 567, 317-320.
23. Mason P. A., Dev B. R., and Freed C. R. (1995) Ascorbic acid concentration in the lateral hypothalamus is related to plasma osmolality. Brain Res. Bull. 37, 305-309.
24. Megyesi J. F. and Del Maestro R. F. (1988) Nuclear magnetic resonance in the investigation of cerebral tumors and cerebral edema: a clue to the cellular alterations that may affect the distribution of water Biochem. Cell Biol. 66, 1100-1109.
25. Miele M., Boutelle M G., and Fillenz M. (1994) The physiologically induced release of ascorbate in rat brain is dependent on impulse traffic, calcium influx and glutamate uptake. Neuroscience 62, 87-91.
26. Mizui T., Kinouchi H., and Chan P. H. (1992) Depletion of brain glutathione by buthionine sulfoximine enhances cerebral ischemic injury in rats. Am. J. Physiol. 262, H313-H317.
27. Naus C. C. G., Bechberger J. F., Caveney S , and Wilson J. X. (1991) Expression of gap junction genes in astrocytes and C6 glioma cells. Neurosci. Lett. 126, 33-36.
28. Oh J. and Chung H. (1994) The effect of ascorbic acid on ischemia and reperfusion injury in rabbit retina. (Abstr) Invest. Ophthalmol. Vis. Sci. 35, 1866.
29. Pasantes-Morales H., Murray R. A , Sanchez-Olea M., and Moran J. (1994) Regulatory volume decrease in cultured astrocytes: II. Permeability pathway to amino acids and polyols. Am. J. Physiol. 266, C172-C178
30. Pazdernik T. L., Romanas M. M., Nelson S. R., and Samson F. E. (1994) The effectiveness of ascorbate and urate as antioxidants at concentrations in brain extracellular fluid. (Abstr.) FASEB J. 8, A674.
31. Ranjan A., Theodore D., Haran R. P , and Chandy M. J. (1993) Ascorbic acid and focal cerebral ischaemia in a primate model. Acta Neurochir. 123, 87-91.
32. Rebec G. V. and Pierce R. C. (1994) A vitamin as neuromodulator: ascorbate release into the extracellular fluid of the brain regulates dopaminergic and glutamatergic transmission. Prog. Neurobiol. 43, 537-565.
33. Reiber H., Ruff M., and Uhr M. (1993) Ascorbate concentration in human cerebrospinal fluid (CSF) and serum. Intrathecal accumulation and CSF flow rate. Clin. Chim. Acta 217, 163-173.
34. + transport in astrocytes in culture. Am. J. Physiol. 264, C836-C842.
35. Sato P. H. and Hall E. D. (1992) Tirilazad mesylate protects vitamins C and E in brain ischemia-reperfusion injury. J. Neurochem. 58, 2263-2268.
36. Sciamanna M. A. and Lee C. P. (1993) Ischemia/reperfusion injury of forebrain mitochondria and protection by ascorbate. Arch. Biochem. Biophys. 305, 215-224.
37. Siushansian R. and Wilson J. X. (1995) Ascorbate transport and intracellular concentration in cerebral astrocytes. J. Neurochem. 65, 41-49.
38. Svensson L., Wu C., Hulthe P., Johannessen K., and Engel J. A. (1993) Effect of ageing on extracellular ascorbate concentration in rat brain. Brain Res. 609, 36-40.
39. Takagi K., Kanemitsu H., Tomukai N., Oka H., Tamura A., Kohno M., Mitsuda K., Yoshika S., and Sano K. (1992) Changes of superoxide dismutase activity and ascorbic acid in focal cerebral ischaemia in rats. Neurol. Res. 14, 26-30.
40. 2+ exchanger in cultured rat astrocytes. J. Neurochem. 64, 1536-1540.
41. Tallaksen C. M. E., Bohmer T., and Bell H. (1992) Concentrations of the water-soluble vitamins thiamin, ascorbic acid, and folic acid in serum and cerebrospinal fluid of healthy individuals. Am. J. Clin. Nutr. 56, 559-564.
42. Uemura Y., Miller J M., Matson W. R., and Real M. F. (1991) Neurochemical analysis of focal ischemia in rats. Stroke 22, 1548-1553.
43. Verbalis J. G. and Gullans S. R. (1991) Hyponatremia causes large sustained reductions in brain content of multiple organic osmolytes in rats Brain Res. 567, 274-282.
44. Videen J. S., Michaelis T., Pinto P., and Ross B. D (1995) Human cerebral osmolytes during chronic hyponatremia - a proton magnetic resonance spectroscopy study. J. Clin Invest 95, 788-793.
45. Wilson J. X. (1989) Ascorbic acid uptake by a high-affinity sodium-dependent mechanism in cultured rat astrocytes. J. Neurochem. 53, 1064-1071.
46. Wilson J. X. and Dixon S. J. (1989) Ascorbic acid transport in mouse and rat astrocytes is reversibly inhibited by furosemide, SITS and DIDS. Neurochem. Res. 14, 1169-1175.
47. Wilson J. X., Jaworski E. M., and Dixon S. J. (1991) Evidence for electrogenic sodium-dependent ascorbate transport in rat astroglia. Neurochem. Res. 16, 73-78.